| # | Title | Journal | Year | Citations |
|---|
| 1 | Microenvironmental regulation of tumor progression and metastasis | Nature Medicine | 2013 | 5,730 |
| 2 | The Emerging Hallmarks of Cancer Metabolism | Cell Metabolism | 2016 | 3,943 |
| 3 | Cancer Metastasis: Building a Framework | Cell | 2006 | 3,702 |
| 4 | TGFβ in Cancer | Cell | 2008 | 3,312 |
| 5 | Microenvironmental regulation of metastasis | Nature Reviews Cancer | 2009 | 3,157 |
| 6 | Somatic mutations affect key pathways in lung adenocarcinoma | Nature | 2008 | 2,694 |
| 7 | TGFβ signalling in context | Nature Reviews Molecular Cell Biology | 2012 | 2,619 |
| 8 | Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate | Cancer Cell | 2012 | 2,617 |
| 9 | Genes that mediate breast cancer metastasis to lung | Nature | 2005 | 2,581 |
| 10 | Metastasis: from dissemination to organ-specific colonization | Nature Reviews Cancer | 2009 | 2,287 |
| 11 | Smad transcription factors | Genes and Development | 2005 | 2,063 |
| 12 | Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis | Nature | 2005 | 1,768 |
| 13 | Endogenous human microRNAs that suppress breast cancer metastasis | Nature | 2008 | 1,743 |
| 14 | T cell exclusion, immune privilege, and the tumor microenvironment | Science | 2015 | 1,735 |
| 15 | IDH mutation impairs histone demethylation and results in a block to cell differentiation | Nature | 2012 | 1,693 |
| 16 | Genes that mediate breast cancer metastasis to the brain | Nature | 2009 | 1,587 |
| 17 | Metastatic colonization by circulating tumour cells | Nature | 2016 | 1,498 |
| 18 | Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer | Nature Reviews Cancer | 2003 | 1,486 |
| 19 | Epithelial-Mesenchymal Transitions | Cell | 2004 | 1,369 |
| 20 | Transforming Growth Factor-β Signaling in Immunity and Cancer | Immunity | 2019 | 1,360 |
| 21 | Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells | Nature | 2013 | 1,316 |
| 22 | Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2020 | 1,195 |
| 23 | Tumor Self-Seeding by Circulating Cancer Cells | Cell | 2009 | 1,182 |
| 24 | Phosphorylation and Functional Inactivation of TSC2 by Erk | Cell | 2005 | 1,132 |
| 25 | G1 cell-cycle control and cancer | Nature | 2004 | 1,082 |
| 26 | TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance | Cancer Cell | 2005 | 1,057 |
| 27 | Characterizing the cancer genome in lung adenocarcinoma | Nature | 2007 | 1,020 |
| 28 | Chromosomal instability drives metastasis through a cytosolic DNA response | Nature | 2018 | 1,002 |
| 29 | The microcosmos of cancer | Nature | 2012 | 993 |
| 30 | A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis | Cell | 2012 | 913 |
| 31 | Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation | Cell | 2004 | 903 |
| 32 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation | Cancer Cell | 2012 | 881 |
| 33 | Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity | Cell | 2007 | 879 |
| 34 | TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4 | Cell | 2008 | 852 |
| 35 | Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 851 |
| 36 | Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells | Nature | 2015 | 772 |
| 37 | SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer | Science | 2017 | 759 |
| 38 | Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs | Nature Medicine | 2011 | 740 |
| 39 | Roles of TGFβ in metastasis | Cell Research | 2009 | 739 |
| 40 | Genetic determinants of cancer metastasis | Nature Reviews Genetics | 2007 | 716 |
| 41 | Senescence-associated reprogramming promotes cancer stemness | Nature | 2018 | 714 |
| 42 | Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer | Nature | 2016 | 677 |
| 43 | Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein | Cancer Research | 2015 | 673 |
| 44 | Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis | Cell | 2014 | 672 |
| 45 | Germline mutations in BAP1 predispose to melanocytic tumors | Nature Genetics | 2011 | 662 |
| 46 | The logic of TGFβ signaling | FEBS Letters | 2006 | 657 |
| 47 | Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression | Cell | 2007 | 652 |
| 48 | Mediators of vascular remodelling co-opted for sequential steps in lung metastasis | Nature | 2007 | 629 |
| 49 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways | Cell | 2009 | 627 |
| 50 | Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals | Cancer Cell | 2009 | 609 |
