| # | Title | Journal | Year | Citations |
|---|
| 1 | How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers | Nature Structural and Molecular Biology | 2007 | 1,288 |
| 2 | The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition | Nature Reviews Molecular Cell Biology | 2010 | 967 |
| 3 | Multivalent engagement of chromatin modifications by linked binding modules | Nature Reviews Molecular Cell Biology | 2007 | 914 |
| 4 | Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics | Nucleic Acids Research | 2007 | 812 |
| 5 | mTOR kinase structure, mechanism and regulation | Nature | 2013 | 805 |
| 6 | Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase | Cell | 2013 | 795 |
| 7 | DNA methylation pathways and their crosstalk with histone methylation | Nature Reviews Molecular Cell Biology | 2015 | 779 |
| 8 | Structure of the Human Telomere in K+Solution: An Intramolecular (3 + 1) G-Quadruplex Scaffold | Journal of the American Chemical Society | 2006 | 759 |
| 9 | Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis | Nature Structural and Molecular Biology | 2014 | 690 |
| 10 | Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF | Nature | 2006 | 689 |
| 11 | Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression | Cell | 2007 | 652 |
| 12 | Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain | Nature | 2004 | 647 |
| 13 | Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures | Nature | 2008 | 634 |
| 14 | Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein | Nature | 2005 | 596 |
| 15 | Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex | Nature | 2008 | 512 |
| 16 | Crystal Structure of the Calcium Release–Activated Calcium Channel Orai | Science | 2012 | 509 |
| 17 | Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs | Chemistry and Biology | 2004 | 505 |
| 18 | Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter | Nature Chemical Biology | 2005 | 483 |
| 19 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes | Nature | 2009 | 483 |
| 20 | Reconstitution, Activities, and Structure of the Eukaryotic RNA Exosome | Cell | 2006 | 482 |
| 21 | Structure of the guide-strand-containing argonaute silencing complex | Nature | 2008 | 481 |
| 22 | Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution † | Nucleic Acids Research | 2007 | 480 |
| 23 | Propeller-Type Parallel-Stranded G-Quadruplexes in the Humanc-mycPromoter | Journal of the American Chemical Society | 2004 | 477 |
| 24 | Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA | Cell | 2013 | 472 |
| 25 | PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing | Nature Structural and Molecular Biology | 2009 | 451 |
| 26 | Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants | Cell | 2012 | 446 |
| 27 | Dicer recognizes the 5′ end of RNA for efficient and accurate processing | Nature | 2011 | 444 |
| 28 | Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex | Nature | 2005 | 423 |
| 29 | Structure of an Unprecedented G-Quadruplex Scaffold in the Humanc-kitPromoter | Journal of the American Chemical Society | 2007 | 418 |
| 30 | Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling | Nature Neuroscience | 2004 | 409 |
| 31 | Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans | Cell | 2005 | 407 |
| 32 | Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch | Nature | 2006 | 404 |
| 33 | Histone chaperone networks shaping chromatin function | Nature Reviews Molecular Cell Biology | 2017 | 401 |
| 34 | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases | Molecular Cell | 2007 | 400 |
| 35 | The evolutionary journey of Argonaute proteins | Nature Structural and Molecular Biology | 2014 | 400 |
| 36 | Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger | Nature | 2009 | 392 |
| 37 | Ribozymes, riboswitches and beyond: regulation of gene expression without proteins | Nature Reviews Genetics | 2007 | 390 |
| 38 | Recognition of DNA damage by the Rad4 nucleotide excision repair protein | Nature | 2007 | 382 |
| 39 | Recognition of small interfering RNA by a viral suppressor of RNA silencing | Nature | 2003 | 379 |
| 40 | Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism | Chemical Reviews | 2018 | 376 |
| 41 | TRIM24 links a non-canonical histone signature to breast cancer | Nature | 2010 | 374 |
| 42 | DNA-guided DNA interference by a prokaryotic Argonaute | Nature | 2014 | 373 |
| 43 | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 | Nature | 2017 | 373 |
| 44 | Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation | Science | 2011 | 363 |
| 45 | Crystal Structure of A. aeolicus Argonaute, a Site-Specific DNA-Guided Endoribonuclease, Provides Insights into RISC-Mediated mRNA Cleavage | Molecular Cell | 2005 | 349 |
| 46 | EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2 | Nature | 2013 | 321 |
| 47 | The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome | Nature | 2012 | 314 |
| 48 | Structure of yeast Argonaute with guide RNA | Nature | 2012 | 314 |
| 49 | Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1 | Nature | 2013 | 310 |
| 50 | Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions | Cell | 2011 | 300 |
