| # | Title | Journal | Year | Citations |
|---|
| 1 | Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing | Science | 2002 | 3,294 |
| 2 | mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery | Cell | 2002 | 2,673 |
| 3 | Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals | Cell | 1994 | 2,065 |
| 4 | Histone demethylation by a family of JmjC domain-containing proteins | Nature | 2006 | 1,846 |
| 5 | Role of histone H2A ubiquitination in Polycomb silencing | Nature | 2004 | 1,502 |
| 6 | DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA | Nature | 2007 | 1,369 |
| 7 | RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs | Cell | 1994 | 1,355 |
| 8 | Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex | Nature | 1995 | 1,355 |
| 9 | Protein S-nitrosylation: a physiological signal for neuronal nitric oxide | Nature Cell Biology | 2001 | 1,321 |
| 10 | TLR signalling augments macrophage bactericidal activity through mitochondrial ROS | Nature | 2011 | 1,303 |
| 11 | The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus | Cell | 1990 | 1,169 |
| 12 | Phosphorylation and Functional Inactivation of TSC2 by Erk | Cell | 2005 | 1,132 |
| 13 | Identification of microRNAs of the herpesvirus family | Nature Methods | 2005 | 1,073 |
| 14 | The importance of repairing stalled replication forks | Nature | 2000 | 1,008 |
| 15 | Immobilized Gallium(III) Affinity Chromatography of Phosphopeptides | Analytical Chemistry | 1999 | 958 |
| 16 | Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription | Nature | 2008 | 904 |
| 17 | GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR | Molecular Cell | 2003 | 883 |
| 18 | Does the ribosome translate cancer? | Nature Reviews Cancer | 2003 | 853 |
| 19 | The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism | Cell | 1997 | 798 |
| 20 | Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin | Molecular Cell | 2004 | 796 |
| 21 | MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex | Nature Genetics | 1999 | 783 |
| 22 | IκB-β regulates the persistent response in a biphasic activation of NF-κB | Cell | 1995 | 758 |
| 23 | JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor | Cell | 2006 | 737 |
| 24 | Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB | Nature | 1996 | 734 |
| 25 | Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2 | Molecular Cell | 2006 | 724 |
| 26 | Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation | Molecular Cell | 1999 | 713 |
| 27 | Regulation of p53 activity through lysine methylation | Nature | 2004 | 706 |
| 28 | Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | Nature | 1999 | 692 |
| 29 | Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor | Science | 2001 | 673 |
| 30 | A positive feedback loop coordinates growth and patterning in the vertebrate limb | Nature | 1994 | 665 |
| 31 | RSC, an Essential, Abundant Chromatin-Remodeling Complex | Cell | 1996 | 654 |
| 32 | Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression | Cell | 2007 | 652 |
| 33 | Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein | Nature | 1993 | 641 |
| 34 | Chromosome Synapsis Defects and Sexually Dimorphic Meiotic Progression in Mice Lacking Spo11 | Molecular Cell | 2000 | 639 |
| 35 | NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN | Cell | 2007 | 630 |
| 36 | Toll signaling pathways in the innate immune response | Current Opinion in Immunology | 2000 | 608 |
| 37 | Pten Dose Dictates Cancer Progression in the Prostate | PLoS Biology | 2003 | 593 |
| 38 | Conversion of Proepithelin to Epithelins | Cell | 2002 | 584 |
| 39 | Mechanism and control of meiotic recombination initiation | Current Topics in Developmental Biology | 2001 | 573 |
| 40 | The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36 | Nature | 2006 | 563 |
| 41 | Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex | Cell | 1997 | 548 |
| 42 | Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila | Science | 2002 | 548 |
| 43 | The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101 | Cell | 1997 | 542 |
| 44 | Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation | Science | 1996 | 533 |
| 45 | Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1 | Nature | 1995 | 530 |
| 46 | PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin | Molecular Cell | 2002 | 525 |
| 47 | Human SWI/SNF-Associated PRMT5 Methylates Histone H3 Arginine 8 and Negatively Regulates Expression of ST7 and NM23 Tumor Suppressor Genes | Molecular and Cellular Biology | 2004 | 524 |
| 48 | Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. | EMBO Journal | 1990 | 521 |
| 49 | A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation | Cell | 2011 | 520 |
| 50 | A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles | Cell | 1994 | 499 |
