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Top Articles

#TitleJournalYearCitations
1Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay MethodCancer Research20104,304
2Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingNature Biotechnology20093,047
3Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic LeukemiaScience Translational Medicine20142,069
4CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic LeukemiaScience Translational Medicine20131,748
5Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid TransformationCancer Cell20111,105
6Engineering strategies to overcome the current roadblocks in CAR T cell therapyNature Reviews Clinical Oncology2020786
7Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase InhibitorsClinical Cancer Research2006783
8Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signaturesGenome Biology2016746
9ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene RepressionCancer Cell2012504
10Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activityNature2011494
11Senolytic CAR T cells reverse senescence-associated pathologiesNature2020483
12Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E MelanomasCancer Cell2012469
13Noninvasive cell-tracking methodsNature Reviews Clinical Oncology2011439
14Therapy-induced tumour secretomes promote resistance and tumour progressionNature2015389
15A vector-free microfluidic platform for intracellular deliveryProceedings of the National Academy of Sciences of the United States of America2013386
16Diverse and Targetable Kinase Alterations Drive Histiocytic NeoplasmsCancer Discovery2016372
17Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestisNature Chemical Biology2005279
18Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivoScience Translational Medicine2015257
19mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA -Mutant Breast CancerScience Translational Medicine2013251
20Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90Nature Chemical Biology2011240
21Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant TumorsCancer Cell2014238
22DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid LeukemiaCell Reports2014237
23L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibitionInternational Journal of Cancer2007236
24JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes MyeloproliferationCancer Cell2011225
25Transforming growth factor  -induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulationProceedings of the National Academy of Sciences of the United States of America2004221
26An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic LeukemiaCancer Cell2012213
27Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expressionNature Biotechnology2012211
28Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3KβCancer Cell2015203
29The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine AcetylationScience2011200
30Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacyBiochemical Society Transactions2016182
31Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2Nature Chemical Biology2013180
32Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell FunctionCell Stem Cell2009174
33Conscripts of the infinite armada: systemic cancer therapy using nanomaterialsNature Reviews Clinical Oncology2010173
34Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein AccumulationStem Cell Reports2016164
35Development and Mechanism of γ-Secretase Modulators for Alzheimer’s DiseaseBiochemistry2013158
36Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7Journal of Experimental Medicine2008157
37AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML SubtypesCancer Cell2014153
38CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic LeukemiaPLoS ONE2013148
39A non-genetic route to aneuploidy in human cancersNature Cell Biology2011147
40Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human AntibodyScience Translational Medicine2013147
41Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancerNature Communications2016144
42The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cellsCancer Cell2006143
43Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemiaBlood2010136
44Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCsJournal of Experimental Medicine2014136
45A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesisNature2013134
46Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinasesCancer Research2002131
47Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cellsNature Biotechnology2015130
48Activation and intrinsic γ-secretase activity of presenilin 1Proceedings of the National Academy of Sciences of the United States of America2010127
49Hypoxia–reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin CFree Radical Biology and Medicine2005125
50Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cellsProceedings of the National Academy of Sciences of the United States of America2007124