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Molecular Pharmacology and Chemistry Program
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top-articles
Molecular Pharmacology and Chemistry Program
284
(top 1%)
papers
31.3K
(top 1%)
citations
78
(top 1%)
h
-index
174
(top 0.1%)
g
-index
293
all documents
33.6K
doc citations
3.3K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
Cancer Research
2010
4,304
2
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Nature Biotechnology
2009
3,047
3
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
Science Translational Medicine
2014
2,069
4
CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
Science Translational Medicine
2013
1,748
5
Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
Cancer Cell
2011
1,105
6
Engineering strategies to overcome the current roadblocks in CAR T cell therapy
Nature Reviews Clinical Oncology
2020
786
7
Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors
Clinical Cancer Research
2006
783
8
Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures
Genome Biology
2016
746
9
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
Cancer Cell
2012
504
10
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
Nature
2011
494
11
Senolytic CAR T cells reverse senescence-associated pathologies
Nature
2020
483
12
Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
Cancer Cell
2012
469
13
Noninvasive cell-tracking methods
Nature Reviews Clinical Oncology
2011
439
14
Therapy-induced tumour secretomes promote resistance and tumour progression
Nature
2015
389
15
A vector-free microfluidic platform for intracellular delivery
Proceedings of the National Academy of Sciences of the United States of America
2013
386
16
Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Cancer Discovery
2016
372
17
Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis
Nature Chemical Biology
2005
279
18
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Science Translational Medicine
2015
257
19
mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in
PIK3CA
-Mutant Breast Cancer
Science Translational Medicine
2013
251
20
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
Nature Chemical Biology
2011
240
21
Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors
Cancer Cell
2014
238
22
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
Cell Reports
2014
237
23
L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition
International Journal of Cancer
2007
236
24
JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
Cancer Cell
2011
225
25
Transforming growth factor -induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation
Proceedings of the National Academy of Sciences of the United States of America
2004
221
26
An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia
Cancer Cell
2012
213
27
Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
Nature Biotechnology
2012
211
28
Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
Cancer Cell
2015
203
29
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation
Science
2011
200
30
Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacy
Biochemical Society Transactions
2016
182
31
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
Nature Chemical Biology
2013
180
32
Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function
Cell Stem Cell
2009
174
33
Conscripts of the infinite armada: systemic cancer therapy using nanomaterials
Nature Reviews Clinical Oncology
2010
173
34
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation
Stem Cell Reports
2016
164
35
Development and Mechanism of γ-Secretase Modulators for Alzheimer’s Disease
Biochemistry
2013
158
36
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
Journal of Experimental Medicine
2008
157
37
AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes
Cancer Cell
2014
153
38
CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia
PLoS ONE
2013
148
39
A non-genetic route to aneuploidy in human cancers
Nature Cell Biology
2011
147
40
Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody
Science Translational Medicine
2013
147
41
Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
Nature Communications
2016
144
42
The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells
Cancer Cell
2006
143
43
Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia
Blood
2010
136
44
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs
Journal of Experimental Medicine
2014
136
45
A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis
Nature
2013
134
46
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases
Cancer Research
2002
131
47
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
Nature Biotechnology
2015
130
48
Activation and intrinsic γ-secretase activity of presenilin 1
Proceedings of the National Academy of Sciences of the United States of America
2010
127
49
Hypoxia–reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C
Free Radical Biology and Medicine
2005
125
50
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
Proceedings of the National Academy of Sciences of the United States of America
2007
124
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