| # | Title | Journal | Year | Citations |
|---|
| 1 | Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer | Science | 2015 | 6,756 |
| 2 | Tumor mutational load predicts survival after immunotherapy across multiple cancer types | Nature Genetics | 2019 | 2,702 |
| 3 | Long Noncoding RNAs in Cancer Pathways | Cancer Cell | 2016 | 2,584 |
| 4 | Genes that mediate breast cancer metastasis to lung | Nature | 2005 | 2,581 |
| 5 | Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients | Nature Medicine | 2017 | 2,473 |
| 6 | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis | Nature | 1996 | 1,789 |
| 7 | Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | Thyroid | 2015 | 1,738 |
| 8 | CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy | Nature | 2019 | 1,528 |
| 9 | Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab | Cell | 2017 | 1,515 |
| 10 | Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice | Science | 2001 | 1,194 |
| 11 | INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation Therapy | Journal of Clinical Oncology | 2002 | 1,153 |
| 12 | Chromosomal instability drives metastasis through a cytosolic DNA response | Nature | 2018 | 1,002 |
| 13 | INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation Therapy | Journal of Clinical Oncology | 2002 | 981 |
| 14 | Comprehensive QA for radiation oncology: Report of AAPM Radiation Therapy Committee Task Group 40 | Medical Physics | 1994 | 974 |
| 15 | Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality | International Journal of Radiation Oncology Biology Physics | 2000 | 885 |
| 16 | Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer | International Journal of Radiation Oncology Biology Physics | 1998 | 876 |
| 17 | Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. | Journal of Experimental Medicine | 1994 | 853 |
| 18 | Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration | Nature | 2015 | 818 |
| 19 | Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis | Cell | 1996 | 780 |
| 20 | Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures | Genome Biology | 2016 | 746 |
| 21 | A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles | Cancer Research | 2001 | 739 |
| 22 | High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients | International Journal of Radiation Oncology Biology Physics | 2002 | 727 |
| 23 | Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma | International Journal of Radiation Oncology Biology Physics | 1989 | 724 |
| 24 | HIGH DOSE RADIATION DELIVERED BY INTENSITY MODULATED CONFORMAL RADIOTHERAPY IMPROVES THE OUTCOME OF LOCALIZED PROSTATE CANCER | Journal of Urology | 2001 | 638 |
| 25 | Incidence of Late Rectal and Urinary Toxicities After Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Localized Prostate Cancer | International Journal of Radiation Oncology Biology Physics | 2008 | 622 |
| 26 | The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma | Nature Genetics | 2011 | 617 |
| 27 | ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach | Annals of Oncology | 2019 | 614 |
| 28 | Intensity-Modulated Radiation Therapy With or Without Chemotherapy for Nasopharyngeal Carcinoma: Radiation Therapy Oncology Group Phase II Trial 0225 | Journal of Clinical Oncology | 2009 | 607 |
| 29 | Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors | Journal of Clinical Investigation | 2005 | 606 |
| 30 | The NOMS Framework: Approach to the Treatment of Spinal Metastatic Tumors | Oncologist | 2013 | 570 |
| 31 | Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy | Nature Medicine | 2000 | 552 |
| 32 | Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation | International Journal of Radiation Oncology Biology Physics | 1999 | 545 |
| 33 | A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy | Nature | 2017 | 532 |
| 34 | An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma | Cancer Cell | 2016 | 531 |
| 35 | High-Dose, Single-Fraction Image-Guided Intensity-Modulated Radiotherapy for Metastatic Spinal Lesions | International Journal of Radiation Oncology Biology Physics | 2008 | 513 |
| 36 | Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease | Immunity | 2012 | 509 |
| 37 | Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer | Radiotherapy and Oncology | 2000 | 490 |
| 38 | Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies | Cancer Discovery | 2017 | 490 |
| 39 | Modern Radiation Therapy for Hodgkin Lymphoma: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group (ILROG) | International Journal of Radiation Oncology Biology Physics | 2014 | 479 |
| 40 | PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors | Nature Genetics | 2014 | 472 |
| 41 | Radiation and ceramide-induced apoptosis | Oncogene | 2003 | 460 |
| 42 | International Spine Radiosurgery Consortium Consensus Guidelines for Target Volume Definition in Spinal Stereotactic Radiosurgery | International Journal of Radiation Oncology Biology Physics | 2012 | 457 |
| 43 | Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma | Cancer | 2015 | 447 |
| 44 | Improved Clinical Outcomes With High-Dose Image Guided Radiotherapy Compared With Non-IGRT for the Treatment of Clinically Localized Prostate Cancer | International Journal of Radiation Oncology Biology Physics | 2012 | 445 |
| 45 | Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2022 | 445 |
| 46 | Multi-institutional analysis of long-term outcome for stages T1–T2 prostate cancer treated with permanent seed implantation | International Journal of Radiation Oncology Biology Physics | 2007 | 440 |
| 47 | Long-Term Outcome of High Dose Intensity Modulated Radiation Therapy for Patients With Clinically Localized Prostate Cancer | Journal of Urology | 2006 | 422 |
| 48 | Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma | Cancer | 2003 | 418 |
| 49 | Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation | Journal of Experimental Medicine | 1997 | 412 |
| 50 | Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer | JAMA Oncology | 2018 | 404 |
