| # | Title | Journal | Year | Citations |
|---|
| 1 | Tumor mutational load predicts survival after immunotherapy across multiple cancer types | Nature Genetics | 2019 | 2,702 |
| 2 | Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients | Nature Medicine | 2017 | 2,473 |
| 3 | Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain | Journal of Pain | 2009 | 1,960 |
| 4 | Glioblastoma and Other Malignant Gliomas | JAMA - Journal of the American Medical Association | 2013 | 1,779 |
| 5 | ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells | Biology of Blood and Marrow Transplantation | 2019 | 1,741 |
| 6 | Brain Tumors | New England Journal of Medicine | 2001 | 1,597 |
| 7 | The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress | European Journal of Cancer | 1994 | 1,301 |
| 8 | Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages | Blood | 2016 | 1,040 |
| 9 | A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle | Nature Medicine | 2012 | 1,029 |
| 10 | An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells | Science | 2013 | 1,014 |
| 11 | Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma | Nature Medicine | 2019 | 932 |
| 12 | Radiation‐induced dementia in patients cured of brain metastases | Neurology | 1989 | 922 |
| 13 | Distinct cortical areas associated with native and second languages | Nature | 1997 | 903 |
| 14 | Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease | Nature Medicine | 2008 | 833 |
| 15 | Brain metastases: epidemiology and pathophysiology | Journal of Neuro-Oncology | 2005 | 816 |
| 16 | Breakthrough pain: definition, prevalence and characteristics | Pain | 1990 | 791 |
| 17 | Chronic use of opioid analgesics in non-malignant pain: Report of 38 cases | Pain | 1986 | 771 |
| 18 | Anti-Hu-Associated Paraneoplastic Encephalomyelitis/Sensory Neuronopathy A Clinical Study of 71 Patients | Medicine (United States) | 1992 | 732 |
| 19 | Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma | Journal of Clinical Oncology | 2005 | 729 |
| 20 | Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts | Journal of Experimental Medicine | 2010 | 715 |
| 21 | Distribution of Brain Metastases | Archives of Neurology | 1988 | 707 |
| 22 | Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer | Nature | 2016 | 677 |
| 23 | The AIDS Dementia Complex | Journal of Infectious Diseases | 1988 | 635 |
| 24 | A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients | American Journal of Psychiatry | 1996 | 595 |
| 25 | Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia | Cancer Discovery | 2018 | 594 |
| 26 | Paraneoplastic cerebellar degeneration. | Neurology | 1992 | 588 |
| 27 | Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status | Annals of Neurology | 1991 | 569 |
| 28 | Long-term survival in primary CNS lymphoma. | Journal of Clinical Oncology | 1998 | 545 |
| 29 | Combined modality therapy for primary CNS lymphoma. | Journal of Clinical Oncology | 1992 | 518 |
| 30 | Character of terminal illness in the advanced cancer patient: Pain and other symptoms during the last four weeks of life | Journal of Pain and Symptom Management | 1990 | 509 |
| 31 | Primary Central Nervous System Lymphoma: The Memorial Sloan-Kettering Cancer Center Prognostic Model | Journal of Clinical Oncology | 2006 | 500 |
| 32 | College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement | Drug and Alcohol Dependence | 2003 | 491 |
| 33 | Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: Clinical and neuropathological findings in 27 patients | Annals of Neurology | 1986 | 479 |
| 34 | Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease | Blood | 2014 | 462 |
| 35 | Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? | Cancer | 2003 | 460 |
| 36 | Opioid therapy for chronic nonmalignant pain: a review of the critical issues | Journal of Pain and Symptom Management | 1996 | 458 |
| 37 | Serum Peptide Profiling by Magnetic Particle-Assisted, Automated Sample Processing and MALDI-TOF Mass Spectrometry | Analytical Chemistry | 2004 | 455 |
| 38 | Radation therapy for brain metastases | Annals of Neurology | 1980 | 434 |
| 39 | Central nervous system excitatory effects of meperidine in cancer patients | Annals of Neurology | 1983 | 416 |
| 40 | Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma | Journal of Neurosurgery | 1989 | 406 |
| 41 | Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice | Neuron | 1999 | 402 |
| 42 | Headaches in patients with brain tumors | Neurology | 1993 | 391 |
| 43 | Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis | Annals of Neurology | 1995 | 385 |
| 44 | Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer?A quantitative western blot analysis | Annals of Neurology | 1990 | 375 |
| 45 | Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms | Cancer Discovery | 2016 | 372 |
| 46 | Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid | Nature | 2019 | 361 |
| 47 | A Serologic Marker of Paraneoplastic Limbic and Brain-Stem Encephalitis in Patients with Testicular Cancer | New England Journal of Medicine | 1999 | 356 |
| 48 | mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc | Cell Metabolism | 2013 | 351 |
| 49 | Leptomeningeal metastases in the MRI era | Neurology | 2010 | 349 |
| 50 | Sedation in the Management of Refractory Symptoms: Guidelines for Evaluation and Treatment | Journal of Palliative Care | 1994 | 341 |
