| # | Title | Journal | Year | Citations |
|---|
| 1 | Inflamm‐aging: An Evolutionary Perspective on Immunosenescence | Annals of the New York Academy of Sciences | 2000 | 3,854 |
| 2 | Tracing European Founder Lineages in the Near Eastern mtDNA Pool | American Journal of Human Genetics | 2000 | 837 |
| 3 | Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans | FASEB Journal | 1999 | 358 |
| 4 | A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages | Genomics | 2005 | 339 |
| 5 | The network and the remodeling theories of aging: historical background and new perspectives | Experimental Gerontology | 2000 | 296 |
| 6 | Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring | Aging | 2015 | 276 |
| 7 | Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly | Experimental Gerontology | 2003 | 268 |
| 8 | Leptin Enhances, via AP-1, Expression of Aromatase in the MCF-7 Cell Line | Journal of Biological Chemistry | 2003 | 249 |
| 9 | Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians | Mechanisms of Ageing and Development | 2005 | 193 |
| 10 | The endocrine role for chromogranin A: A prohormone for peptides with regulatory properties | Cellular and Molecular Life Sciences | 2007 | 185 |
| 11 | A Predominantly Neolithic Origin for Y-Chromosomal DNA Variation in North Africa | American Journal of Human Genetics | 2004 | 173 |
| 12 | Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease | Human Genetics | 2001 | 154 |
| 13 | A Genome Scan for Modifiers of Age at Onset in Huntington Disease: The HD MAPS Study | American Journal of Human Genetics | 2003 | 148 |
| 14 | Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease | | 2003 | 146 |
| 15 | The Antihypertensive Chromogranin A Peptide Catestatin Acts as a Novel Endocrine/Paracrine Modulator of Cardiac Inotropism and Lusitropism | Endocrinology | 2008 | 144 |
| 16 | DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma | Oncotarget | 2012 | 138 |
| 17 | The Genetics of Human Longevity | Annals of the New York Academy of Sciences | 2006 | 124 |
| 18 | 17β-Estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ERα | Molecular and Cellular Endocrinology | 2010 | 122 |
| 19 | Breast cancer: from estrogen to androgen receptor | Molecular and Cellular Endocrinology | 2002 | 120 |
| 20 | Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency | Human Mutation | 2003 | 117 |
| 21 | Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease | PLoS ONE | 2010 | 117 |
| 22 | Global DNA methylation levels are modulated by mitochondrial DNA variants | Epigenomics | 2012 | 117 |
| 23 | Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians | European Journal of Human Genetics | 2001 | 116 |
| 24 | Proteins from the prokaryotic nucleoid: primary and quaternary structure of the 15-kD Escherichia coli DNA binding protein H-NS | Molecular Microbiology | 1988 | 112 |
| 25 | The G/C915 polymorphism of transforming growth factor β1 is associated with human longevity: a study in Italian centenarians | Aging Cell | 2004 | 112 |
| 26 | Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe | Human Genetics | 2004 | 104 |
| 27 | Human Ejaculated Spermatozoa Contain Active P450 Aromatase | Journal of Clinical Endocrinology and Metabolism | 2002 | 99 |
| 28 | The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes | PLoS ONE | 2011 | 94 |
| 29 | Association of the mitochondrial DNA haplogroup J with longevity is population specific | European Journal of Human Genetics | 2004 | 93 |
| 30 | The G Protein-coupled Receptor 30 Is Up-regulated by Hypoxia-inducible Factor-1α (HIF-1α) in Breast Cancer Cells and Cardiomyocytes | Journal of Biological Chemistry | 2011 | 93 |
| 31 | Diabetic rat testes: morphological and functional alterations | Andrologia | 2009 | 92 |
| 32 | Global DNA methylation in old subjects is correlated with frailty | Age | 2012 | 91 |
| 33 | Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury | Cellular and Molecular Life Sciences | 2013 | 87 |
| 34 | The co‐occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific | Aging Cell | 2014 | 85 |
| 35 | Endogenous Coactivator ARA70 Interacts with Estrogen Receptor α (ERα) and Modulates the Functional ERα/Androgen Receptor Interplay in MCF-7 Cells | Journal of Biological Chemistry | 2005 | 79 |
| 36 | Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13 | Genomics | 2007 | 78 |
| 37 | Chromogranin A and Derived Peptides in Health and Disease | Journal of Molecular Neuroscience | 2012 | 76 |
| 38 | Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH–INS genes | Experimental Gerontology | 2001 | 74 |
| 39 | Novel acrylamido monomers with higher hydrophilicity and improved hydrolytic stability: II. Properties ofN-acryloylaminopropanol | Electrophoresis | 1996 | 73 |
| 40 | Wall adsorption in capillary electrophoresis experimental study and computer simulation | Journal of Chromatography A | 1995 | 72 |
| 41 | Epigenetics and aging | Maturitas | 2013 | 72 |
| 42 | Nitric Oxide Modulates Cardiac Performance in the Heart of Anguilla Anguilla | Journal of Experimental Biology | 2001 | 71 |
| 43 | The Unusual Genetics of Human Longevity | Science of Aging Knowledge Environment: SAGE KE | 2006 | 70 |
| 44 | Leptin increases HER2 protein levels through a STAT3‐mediated up‐regulation of Hsp90 in breast cancer cells | Molecular Oncology | 2013 | 69 |
| 45 | The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect | Biogerontology | 2010 | 68 |
| 46 | Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart | Cellular and Molecular Neurobiology | 2010 | 68 |
| 47 | What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians | Experimental Gerontology | 2002 | 67 |
| 48 | Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16 | Neurogenetics | 2004 | 67 |
| 49 | Prognostic Significance of the Short Physical Performance Battery in Older Patients Discharged from Acute Care Hospitals | Rejuvenation Research | 2012 | 67 |
| 50 | Role of Calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production | Journal of Steroid Biochemistry and Molecular Biology | 1996 | 66 |
