# | Title | Journal | Year | Citations |
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1 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
2 | Oesophageal cancer | Lancet, The | 2017 | 796 |
3 | Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle | Cell Metabolism | 2012 | 729 |
4 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
5 | Oesophageal cancer | Nature Reviews Disease Primers | 2017 | 671 |
6 | Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density | Cell Metabolism | 2009 | 530 |
7 | Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project | BMJ, The | 2014 | 481 |
8 | Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease | Hepatology | 2013 | 454 |
9 | Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial | Lancet Oncology, The | 2017 | 447 |
10 | A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism | Nature Genetics | 2006 | 418 |
11 | Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database | Nature Genetics | 2014 | 410 |
12 | The Epidemiology of Esophageal Adenocarcinoma | Gastroenterology | 2018 | 389 |
13 | Breast Cancer in Young Women: Poor Survival Despite Intensive Treatment | PLoS ONE | 2009 | 371 |
14 | Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy | Nature Genetics | 2007 | 353 |
15 | Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study | Lancet, The | 2016 | 306 |
16 | Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events: Results from 11 European Cohorts within the ESCAPE Project | Environmental Health Perspectives | 2014 | 285 |
17 | Identification of proliferative and mature β-cells in the islets of Langerhans | Nature | 2016 | 279 |
18 | Genetic loci influencing kidney function and chronic kidney disease | Nature Genetics | 2010 | 246 |
19 | Anal cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2014 | 244 |
20 | Platelet‐ and erythrocyte‐derived microparticles trigger thrombin generation via factor XIIa | Journal of Thrombosis and Haemostasis | 2012 | 243 |
21 | Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer – the RAPIDO trial | BMC Cancer | 2013 | 237 |
22 | Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up | European Journal of Surgical Oncology | 2014 | 237 |
23 | Survival in breast cancer after nipple-sparing subcutaneous mastectomy and immediate reconstruction with implants: A prospective trial with 13 years median follow-up in 216 patients | European Journal of Surgical Oncology | 2008 | 235 |
24 | The risk of revision due to dislocation after total hip arthroplasty depends on surgical approach, femoral head size, sex, and primary diagnosis | Monthly Notices of the Royal Astronomical Society: Letters | 2012 | 221 |
25 | Thyroid-Associated Ophthalmopathy after Treatment for Graves’ Hyperthyroidism with Antithyroid Drugs or Iodine-131 | Journal of Clinical Endocrinology and Metabolism | 2009 | 219 |
26 | Particulate matter air pollution components and risk for lung cancer | Environment International | 2016 | 219 |
27 | Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency | Clinical Endocrinology | 2008 | 217 |
28 | Circulating biomarkers for early detection and clinical management of colorectal cancer | Molecular Aspects of Medicine | 2019 | 214 |
29 | Impaired Gene and Protein Expression of Exocytotic Soluble N-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients | Diabetes | 2006 | 206 |
30 | Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis | Journal of Bone and Joint Surgery: British Volume | 2009 | 193 |
31 | Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder | Human Molecular Genetics | 2016 | 182 |
32 | Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management | Endocrine Reviews | 2022 | 182 |
33 | Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm | Nature Genetics | 2010 | 181 |
34 | siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle | Cell Metabolism | 2006 | 180 |
35 | Anal cancer: ESMO–ESSO–ESTRO clinical practice guidelines for diagnosis, treatment and follow-up | Radiotherapy and Oncology | 2014 | 179 |
36 | Clinical and pre-clinical pain assessment: Are we measuring the same thing? | Pain | 2008 | 176 |
37 | Global Burden of Colistin-Resistant Bacteria: Mobilized Colistin Resistance Genes Study (1980–2018) | Microorganisms | 2019 | 175 |
38 | Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK | Gut | 2006 | 173 |
39 | Omega-3 Fatty Acids for Nutrition and Medicine: Considering Microalgae Oil as a Vegetarian Source of EPA and DHA | Current Diabetes Reviews | 2007 | 173 |
40 | Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle | Diabetes | 2007 | 166 |
41 | Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation | Circulation | 2019 | 165 |
42 | Stage at diagnosis and colorectal cancer survival in six high-income countries: A population-based study of patients diagnosed during 2000–2007 | Acta Oncológica | 2013 | 163 |
43 | Gastroesophageal Reflux Disease | JAMA - Journal of the American Medical Association | 2020 | 163 |
44 | Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study | European Heart Journal | 2016 | 159 |
45 | Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression | Cell | 2009 | 157 |
46 | The Science Behind the Academy for Eating Disorders' Nine Truths About Eating Disorders | European Eating Disorders Review | 2017 | 156 |
47 | Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report | PLoS ONE | 2013 | 156 |
48 | Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter | PLoS ONE | 2012 | 154 |
49 | Individualized dosimetry in patients undergoing therapy with 177Lu-DOTA-D-Phe1-Tyr3-octreotate | European Journal of Nuclear Medicine and Molecular Imaging | 2010 | 152 |
50 | Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer | JAMA Oncology | 2019 | 152 |