| # | Title | Journal | Year | Citations |
|---|
| 1 | HMG-1 as a Late Mediator of Endotoxin Lethality in Mice | Science | 1999 | 3,807 |
| 2 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer | Cell Stem Cell | 2007 | 2,534 |
| 3 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME | Archives of Toxicology | 2013 | 1,089 |
| 4 | Biologics for tendon repair | Advanced Drug Delivery Reviews | 2015 | 500 |
| 5 | Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery | Lancet, The | 1993 | 382 |
| 6 | THE BENEFICIAL EFFECT OF HUMAN RECOMBINANT SUPEROXIDE DISMUTASE ON ACUTE AND CHRONIC REJECTION EVENTS IN RECIPIENTS OF CADAVERIC RENAL TRANSPLANTS | Transplantation | 1994 | 361 |
| 7 | Comparison of endoscopic procedures vs Lichtenstein and other open mesh techniques for inguinal hernia repair: a meta-analysis of randomized controlled trials | Surgical Endoscopy and Other Interventional Techniques | 2005 | 357 |
| 8 | Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery. | Journal of Clinical Oncology | 1994 | 347 |
| 9 | The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages | European Journal of Immunology | 1993 | 345 |
| 10 | E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration | Cancer Research | 1993 | 336 |
| 11 | Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome | Intensive Care Medicine | 2000 | 326 |
| 12 | Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation | World Journal of Surgery | 1996 | 294 |
| 13 | Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system | Journal of Cellular and Molecular Medicine | 2007 | 274 |
| 14 | c-erbB-2 Is of Independent Prognostic Relevance in Gastric Cancer and Is Associated With the Expression of Tumor-Associated Protease Systems | Journal of Clinical Oncology | 2000 | 257 |
| 15 | Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data | BMJ, The | 2014 | 252 |
| 16 | Effectiveness of Radical Systematic Mediastinal Lymphadenectomy in Patients With Resectable Non-Small Cell Lung Cancer | Annals of Surgery | 1998 | 252 |
| 17 | Activation of Src kinase in primary colorectal carcinoma | Cancer | 2002 | 249 |
| 18 | Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer | Nature Medicine | 1995 | 238 |
| 19 | De-novo expression of CD44 and survival in gastric cancer | Lancet, The | 1993 | 230 |
| 20 | Hemodilution | Surgical Clinics of North America | 1975 | 228 |
| 21 | Clinical review: immunodepression in the surgical patient and increased susceptibility to infection | Critical Care | 2002 | 228 |
| 22 | Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. | Journal of Clinical Oncology | 1998 | 226 |
| 23 | Extended pancreatectomy in pancreatic ductal adenocarcinoma: Definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS) | Surgery | 2014 | 226 |
| 24 | Prognostic significance of bone marrow micrometastases in patients with gastric cancer. | Journal of Clinical Oncology | 1996 | 196 |
| 25 | Indicators of the Posttraumatic Inflammatory Response Correlate with Organ Failure in Patients with Multiple Injuries | Arteriosclerosis, Thrombosis, and Vascular Biology | 1997 | 196 |
| 26 | Apoptosis and immunohistochemicalbcl-2 expression in colorectal adenomas and carcinomas: Aspects of carcinogenesis and prognostic significance | | 1996 | 195 |
| 27 | Treatment of Lymphedemas by Microsurgical Lymphatic Grafting | Plastic and Reconstructive Surgery | 1990 | 191 |
| 28 | Inflammatory Mediators, Infection, Sepsis, and Multiple Organ Failure After Severe Trauma | Archives of Surgery | 1992 | 185 |
| 29 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Liver, Bladder, Cervical, and Gastric Cancers | Clinical Chemistry | 2010 | 184 |
| 30 | Posttraumatic Inflammatory Response, Secondary Operations, and Late Multiple Organ Failure | Arteriosclerosis, Thrombosis, and Vascular Biology | 1996 | 183 |
| 31 | Pancreatic Adenocarcinoma | Annals of Surgery | 2015 | 180 |
| 32 | Immunohistochemical assessment of individual tumor cells in lymph nodes of patients with non-small-cell lung cancer. | Journal of Clinical Oncology | 1994 | 178 |
| 33 | Introducing a single‐cell‐derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer | Journal of Cellular and Molecular Medicine | 2008 | 177 |
| 34 | Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS) | Surgery | 2017 | 177 |
| 35 | Inflammatory Mediators are Altered in the Acute Phase of Posttraumatic Complex Regional Pain Syndrome | Clinical Journal of Pain | 2006 | 176 |
| 36 | Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis | Kidney International | 2007 | 174 |
| 37 | Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy | Journal of Cellular and Molecular Medicine | 2008 | 172 |
| 38 | Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia* | Critical Care Medicine | 2004 | 156 |
| 39 | Captopril enhances insulin responsiveness of forearm muscle tissue in non‐insulin‐dependent diabetes mellitus | European Journal of Clinical Investigation | 1987 | 153 |
| 40 | Radical systematic mediastinal lymphadenectomy in non-small cell lung cancer: A randomized controlled trial | British Journal of Surgery | 2005 | 153 |
| 41 | Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF541): Data from a prospective, randomized, multicenter trial* | Critical Care Medicine | 2007 | 153 |
| 42 | Comparison of endoscopic techniques vs Shouldice and other open nonmesh techniques for inguinal hernia repair: a meta-analysis of randomized controlled trials | Surgical Endoscopy and Other Interventional Techniques | 2005 | 152 |
| 43 | Immunological Effects of Laparoscopic vs Open Colorectal Surgery | Archives of Surgery | 2005 | 152 |
| 44 | The effects of digital anaesthesia on predictive grip force adjustments during vertical movements of a grasped object | European Journal of Neuroscience | 2001 | 150 |
| 45 | Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S | Journal of Proteome Research | 2011 | 148 |
| 46 | The janus face of immunosuppression – de novo malignancy after renal transplantation: the experience of the Transplantation Center Munich | Kidney International | 2007 | 146 |
| 47 | A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma | BMC Cancer | 2010 | 146 |
| 48 | Hydroxyethyl Starch (130 kD), but Not Crystalloid Volume Support, Improves Microcirculation during Normotensive Endotoxemia | Anesthesiology | 2002 | 145 |
| 49 | Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors | Cancer | 2003 | 145 |
| 50 | Wnt Signaling Regulates the Invasion Capacity of Human Mesenchymal Stem Cells | Stem Cells | 2006 | 143 |
