| # | Title | Journal | Year | Citations |
|---|
| 1 | Tumour evolution inferred by single-cell sequencing | Nature | 2011 | 2,313 |
| 2 | m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program | Cancer Cell | 2017 | 1,131 |
| 3 | Clonal evolution in breast cancer revealed by single nucleus genome sequencing | Nature | 2014 | 911 |
| 4 | Toward understanding and exploiting tumor heterogeneity | Nature Medicine | 2015 | 604 |
| 5 | Advances and Applications of Single-Cell Sequencing Technologies | Molecular Cell | 2015 | 485 |
| 6 | Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice | PLoS Genetics | 2014 | 456 |
| 7 | Gain of function of mutant p53 by coaggregation with multiple tumor suppressors | Nature Chemical Biology | 2011 | 450 |
| 8 | Punctuated copy number evolution and clonal stasis in triple-negative breast cancer | Nature Genetics | 2016 | 396 |
| 9 | The myotonic dystrophies: molecular, clinical, and therapeutic challenges | Lancet Neurology, The | 2012 | 390 |
| 10 | Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer | Cancer Cell | 2013 | 388 |
| 11 | Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer | Nature Genetics | 2014 | 360 |
| 12 | Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome | Clinical Cancer Research | 2017 | 358 |
| 13 | Genome-wide copy number analysis of single cells | Nature Protocols | 2012 | 332 |
| 14 | The first five years of single-cell cancer genomics and beyond | Genome Research | 2015 | 324 |
| 15 | Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing | Cell | 2018 | 324 |
| 16 | mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation | Nature Communications | 2021 | 317 |
| 17 | Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes | Nature Biotechnology | 2021 | 306 |
| 18 | Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study | Lancet Oncology, The | 2017 | 296 |
| 19 | Mdm2-mediated ubiquitylation: p53 and beyond | Cell Death and Differentiation | 2010 | 287 |
| 20 | p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer | Cancer Cell | 2012 | 279 |
| 21 | A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor | Nature Genetics | 2017 | 255 |
| 22 | Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors | Cancer Cell | 2015 | 244 |
| 23 | Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice | Diabetes | 2018 | 243 |
| 24 | Tumor evolution: Linear, branching, neutral or punctuated? | Biochimica Et Biophysica Acta: Reviews on Cancer | 2017 | 239 |
| 25 | COSA-1 Reveals Robust Homeostasis and Separable Licensing and Reinforcement Steps Governing Meiotic Crossovers | Cell | 2012 | 231 |
| 26 | Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation | Nature Structural and Molecular Biology | 2012 | 227 |
| 27 | Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma | Nature Genetics | 2015 | 218 |
| 28 | Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene | Nature Reviews Cancer | 2011 | 217 |
| 29 | Mutant p53 partners in crime | Cell Death and Differentiation | 2018 | 216 |
| 30 | Systematic Functional Annotation of Somatic Mutations in Cancer | Cancer Cell | 2018 | 213 |
| 31 | Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma | Nature Genetics | 2018 | 212 |
| 32 | Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics | Nature Communications | 2020 | 208 |
| 33 | USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses | Nature Immunology | 2014 | 204 |
| 34 | A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue | Cell | 2011 | 193 |
| 35 | Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer | Genome Research | 2017 | 189 |
| 36 | Future medical applications of single-cell sequencing in cancer | Genome Medicine | 2011 | 180 |
| 37 | Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis | Arthritis and Rheumatism | 2010 | 170 |
| 38 | The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 167 |
| 39 | Novel MYBL1 Gene Rearrangements with Recurrent MYBL1–NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations | Clinical Cancer Research | 2016 | 167 |
| 40 | The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres | EMBO Journal | 2010 | 158 |
| 41 | Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression | Cancer Cell | 2011 | 158 |
| 42 | Melatonin synergizes the chemotherapeutic effect of 5‐fluorouracil in colon cancer by suppressing PI3K/AKT and NF‐κB/iNOS signaling pathways | Journal of Pineal Research | 2017 | 158 |
| 43 | Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma | Nature Medicine | 2011 | 155 |
| 44 | Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging | JAMA Oncology | 2017 | 148 |
| 45 | Breast tumours maintain a reservoir of subclonal diversity during expansion | Nature | 2021 | 145 |
| 46 | Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase | EMBO Journal | 2010 | 143 |
| 47 | Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration | Cell Host and Microbe | 2018 | 141 |
| 48 | Children's Oncology Group's 2013 blueprint for research: Renal tumors | Pediatric Blood and Cancer | 2013 | 140 |
| 49 | Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility | Nature Genetics | 2020 | 138 |
| 50 | Conserved insulin signaling in the regulation of oocyte growth, development, and maturation | Molecular Reproduction and Development | 2017 | 136 |
