| # | Title | Journal | Year | Citations |
|---|
| 1 | NF-κB signaling in inflammation | Signal Transduction and Targeted Therapy | 2017 | 4,812 |
| 2 | A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 | Nature Immunology | 2005 | 3,869 |
| 3 | Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients | Science | 2018 | 3,126 |
| 4 | Fundamental Mechanisms of Immune Checkpoint Blockade Therapy | Cancer Discovery | 2018 | 2,128 |
| 5 | Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival | Cancer Cell | 2014 | 1,892 |
| 6 | Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential | Cell | 2015 | 1,872 |
| 7 | Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens | Nature | 2014 | 1,705 |
| 8 | A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB | EMBO Journal | 2012 | 1,507 |
| 9 | B cells and tertiary lymphoid structures promote immunotherapy response | Nature | 2020 | 1,421 |
| 10 | Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma | Journal of Experimental Medicine | 2013 | 1,203 |
| 11 | The non-canonical NF-κB pathway in immunity and inflammation | Nature Reviews Immunology | 2017 | 1,174 |
| 12 | Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy | Cancer Discovery | 2016 | 1,158 |
| 13 | Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages | Immunity | 2008 | 1,059 |
| 14 | Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy | Cell | 2016 | 1,009 |
| 15 | Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade | Cell | 2017 | 960 |
| 16 | TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand | Journal of Experimental Medicine | 2005 | 952 |
| 17 | TH17 cells in development: an updated view of their molecular identity and genetic programming | Nature Reviews Immunology | 2008 | 939 |
| 18 | Non-canonical NF-κB signaling pathway | Cell Research | 2011 | 905 |
| 19 | Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade | Cancer Discovery | 2016 | 785 |
| 20 | Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression | Nature Communications | 2014 | 780 |
| 21 | The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells | Nature Immunology | 2011 | 759 |
| 22 | Mitogen-activated protein kinase cascades and regulation of gene expression | Current Opinion in Immunology | 1996 | 722 |
| 23 | Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities | Cancer Discovery | 2015 | 696 |
| 24 | Regulation of inflammatory responses by IL-17F | Journal of Experimental Medicine | 2008 | 690 |
| 25 | Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance | Science Translational Medicine | 2017 | 689 |
| 26 | T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity | Immunity | 2009 | 679 |
| 27 | Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity | Nature Communications | 2016 | 648 |
| 28 | Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism | Nature | 2016 | 648 |
| 29 | Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation | Immunity | 2014 | 645 |
| 30 | The noncanonical NF‐κB pathway | Immunological Reviews | 2012 | 604 |
| 31 | Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma | Nature Medicine | 2018 | 592 |
| 32 | Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy | Science Translational Medicine | 2014 | 590 |
| 33 | TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation | Annual Review of Immunology | 2007 | 566 |
| 34 | Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis | Nature Medicine | 2018 | 521 |
| 35 | The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C | EMBO Journal | 2008 | 482 |
| 36 | STAT3 signaling in immunity | Cytokine and Growth Factor Reviews | 2016 | 466 |
| 37 | Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients? | American Society of Clinical Oncology Educational Book / ASCO American Society of Clinical Oncology Meeting | 2019 | 459 |
| 38 | Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells | Nature Reviews Immunology | 2006 | 447 |
| 39 | Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer | Nature Communications | 2017 | 432 |
| 40 | The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis | Nature Communications | 2014 | 427 |
| 41 | Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner | Cell Reports | 2015 | 387 |
| 42 | Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study | Cancer Discovery | 2019 | 380 |
| 43 | Ubiquitin signaling in immune responses | Cell Research | 2016 | 372 |
| 44 | Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response | Science | 2021 | 369 |
| 45 | The Next Decade of Immune Checkpoint Therapy | Cancer Discovery | 2021 | 363 |
| 46 | MOLECULAR MECHANISMS OF ULTRAVIOLET RADIATION CARCINOGENESIS | Photochemistry and Photobiology | 1990 | 353 |
| 47 | HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas | Oncogene | 2005 | 353 |
| 48 | Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16–Related Cancer | JAMA Oncology | 2019 | 344 |
| 49 | CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes | Cell Death and Differentiation | 2010 | 338 |
| 50 | The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets | Nature Immunology | 2011 | 328 |
