# | Title | Journal | Year | Citations |
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1 | Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients | Science | 2018 | 3,126 |
2 | A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis | American Journal of Human Genetics | 2004 | 1,313 |
3 | Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing | Science | 2014 | 834 |
4 | Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes | Cell | 2019 | 830 |
5 | Identification of seven loci affecting mean telomere length and their association with disease | Nature Genetics | 2013 | 808 |
6 | Functional variants of OCTN cation transporter genes are associated with Crohn disease | Nature Genetics | 2004 | 749 |
7 | Estimated Projection of US Cancer Incidence and Death to 2040 | JAMA Network Open | 2021 | 566 |
8 | Detectable clonal mosaicism and its relationship to aging and cancer | Nature Genetics | 2012 | 519 |
9 | Detectable clonal mosaicism from birth to old age and its relationship to cancer | Nature Genetics | 2012 | 511 |
10 | Common 5p15.33 and 6p21.33 variants influence lung cancer risk | Nature Genetics | 2008 | 510 |
11 | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci | Nature Genetics | 2010 | 493 |
12 | Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes | Nature Genetics | 2017 | 472 |
13 | Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC) | Head & Neck Oncology | 2010 | 423 |
14 | STrengthening the REporting of Genetic Association Studies (STREGA)— An Extension of the STROBE Statement | PLoS Medicine | 2009 | 411 |
15 | A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer | Nature Genetics | 2014 | 408 |
16 | Gastric cancer—molecular and clinical dimensions | Nature Reviews Clinical Oncology | 2013 | 376 |
17 | Inherited causes of clonal haematopoiesis in 97,691 whole genomes | Nature | 2020 | 376 |
18 | Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response | Science | 2021 | 369 |
19 | Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer | Nature Genetics | 2014 | 360 |
20 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
21 | CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade | Cancer Discovery | 2018 | 323 |
22 | The landscape of recombination in African Americans | Nature | 2011 | 319 |
23 | Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study | Lancet Oncology, The | 2017 | 296 |
24 | Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis | PLoS ONE | 2011 | 292 |
25 | Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer | Gastroenterology | 2019 | 270 |
26 | Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression | Clinical Cancer Research | 2019 | 268 |
27 | Cancer Stem Cells: The Promise and the Potential | Seminars in Oncology | 2015 | 256 |
28 | A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway | Nature Cell Biology | 2014 | 252 |
29 | Modulating the microbiome to improve therapeutic response in cancer | Lancet Oncology, The | 2019 | 249 |
30 | Childhood intelligence is heritable, highly polygenic and associated with FNBP1L | Molecular Psychiatry | 2014 | 241 |
31 | Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia | Nature Genetics | 2011 | 239 |
32 | Mitochondrial DNA Content: Its Genetic Heritability and Association With Renal Cell Carcinoma | Journal of the National Cancer Institute | 2008 | 237 |
33 | A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry | Nature Genetics | 2013 | 232 |
34 | Gene and pathway-based second-wave analysis of genome-wide association studies | European Journal of Human Genetics | 2010 | 228 |
35 | Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trials | Lancet Haematology,the | 2015 | 227 |
36 | Identification of six new susceptibility loci for invasive epithelial ovarian cancer | Nature Genetics | 2015 | 221 |
37 | Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3 | Nature Genetics | 2011 | 220 |
38 | Genetic variants and risk of lung cancer in never smokers: a genome-wide association study | Lancet Oncology, The | 2010 | 218 |
39 | STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement | Genetic Epidemiology | 2009 | 211 |
40 | Osteoradionecrosis and Radiation Dose to the Mandible in Patients With Oropharyngeal Cancer | International Journal of Radiation Oncology Biology Physics | 2013 | 209 |
41 | The CHRNA5-A3 Region on Chromosome 15q24-25.1 Is a Risk Factor Both for Nicotine Dependence and for Lung Cancer | Journal of the National Cancer Institute | 2008 | 206 |
42 | Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk | Cancer Prevention Research | 2008 | 206 |
43 | Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma | Oncogene | 2010 | 196 |
44 | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer | Nature Communications | 2018 | 188 |
45 | Genome-wide association study identifies novel loci predisposing to cutaneous melanoma† | Human Molecular Genetics | 2011 | 187 |
46 | Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis | American Journal of Human Genetics | 2014 | 182 |
47 | Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent | Prostate Cancer | 2013 | 180 |
48 | Phevor Combines Multiple Biomedical Ontologies for Accurate Identification of Disease-Causing Alleles in Single Individuals and Small Nuclear Families | American Journal of Human Genetics | 2014 | 175 |
49 | A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus | Nature Genetics | 2013 | 174 |
50 | PALB2,CHEK2andATMrare variants and cancer risk: data from COGS | Journal of Medical Genetics | 2016 | 174 |