| # | Title | Journal | Year | Citations |
|---|
| 1 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,979 |
| 2 | The 2015 World Health Organization Classification of Lung Tumors | Journal of Thoracic Oncology | 2015 | 3,313 |
| 3 | Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients | Science | 2018 | 3,126 |
| 4 | Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma | Cancer Cell | 2010 | 2,078 |
| 5 | Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer | Cell | 2017 | 1,742 |
| 6 | Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma | Cell | 2016 | 1,695 |
| 7 | B cells and tertiary lymphoid structures promote immunotherapy response | Nature | 2020 | 1,421 |
| 8 | Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy | Cancer Cell | 2014 | 1,358 |
| 9 | Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy | Cancer Discovery | 2016 | 1,158 |
| 10 | B cells are associated with survival and immunotherapy response in sarcoma | Nature | 2020 | 1,158 |
| 11 | STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma | Cancer Discovery | 2018 | 1,108 |
| 12 | Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine | Science | 2017 | 1,059 |
| 13 | Bladder cancer | Lancet, The | 2016 | 1,031 |
| 14 | Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function | Nature | 2014 | 998 |
| 15 | Clonal evolution in breast cancer revealed by single nucleus genome sequencing | Nature | 2014 | 911 |
| 16 | Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation | Nature | 2011 | 834 |
| 17 | Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing | Science | 2014 | 834 |
| 18 | Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice | Nature Genetics | 2000 | 827 |
| 19 | Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade | Cancer Discovery | 2016 | 785 |
| 20 | Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma | Science | 2012 | 716 |
| 21 | ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect | Nature Cell Biology | 2012 | 693 |
| 22 | Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance | Science Translational Medicine | 2017 | 689 |
| 23 | The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma | Cancer Cell | 2014 | 665 |
| 24 | Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity | Nature Communications | 2016 | 648 |
| 25 | PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis | Cell | 2012 | 635 |
| 26 | Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer | Cancer | 2011 | 624 |
| 27 | Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma | Cancer Cell | 2011 | 613 |
| 28 | Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma | Nature Medicine | 2018 | 592 |
| 29 | Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer | British Journal of Cancer | 2012 | 585 |
| 30 | Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer | Cell | 2014 | 553 |
| 31 | Is cross-validation valid for small-sample microarray classification? | Bioinformatics | 2004 | 546 |
| 32 | Deubiquitination and Stabilization of PD-L1 by CSN5 | Cancer Cell | 2016 | 538 |
| 33 | The integrated landscape of driver genomic alterations in glioblastoma | Nature Genetics | 2013 | 524 |
| 34 | t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway | Nature Genetics | 2003 | 523 |
| 35 | Epigenomic alterations define lethal CIMP-positive ependymomas of infancy | Nature | 2014 | 521 |
| 36 | Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis | Nature Medicine | 2018 | 521 |
| 37 | PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis | Nature Cell Biology | 2020 | 508 |
| 38 | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci | Nature Genetics | 2010 | 493 |
| 39 | Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma | Clinical Cancer Research | 2014 | 493 |
| 40 | Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 | Molecular Cell | 2018 | 491 |
| 41 | VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer | Nature Medicine | 2017 | 467 |
| 42 | Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer | JAMA - Journal of the American Medical Association | 2011 | 466 |
| 43 | Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways | Nature Medicine | 2011 | 466 |
| 44 | The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers | Nature Medicine | 2004 | 463 |
| 45 | Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators | Cancer | 2012 | 457 |
| 46 | Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin Mutations | American Journal of Pathology | 2002 | 451 |
| 47 | Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer | Nature Communications | 2017 | 432 |
| 48 | Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint | Lancet Oncology, The | 2014 | 427 |
| 49 | Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression | Cancer Discovery | 2016 | 404 |
| 50 | Effective combinatorial immunotherapy for castration-resistant prostate cancer | Nature | 2017 | 403 |
