| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 2 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 3 | Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society | Clinical Infectious Diseases | 2016 | 2,405 |
| 4 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,292 |
| 5 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 6 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
| 7 | Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease | Gastroenterology | 2015 | 2,200 |
| 8 | Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study | Lancet, The | 2016 | 1,414 |
| 9 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,230 |
| 10 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 11 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 12 | Reducing Inappropriate Polypharmacy | JAMA Internal Medicine | 2015 | 1,054 |
| 13 | Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases | Gut | 2017 | 807 |
| 14 | Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance | Blood | 2005 | 799 |
| 15 | Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 786 |
| 16 | Patients With Prior Myocardial Infarction, Stroke, or Symptomatic Peripheral Arterial Disease in the CHARISMA Trial | Journal of the American College of Cardiology | 2007 | 752 |
| 17 | Definition of the Mediterranean Diet; A Literature Review | Nutrients | 2015 | 703 |
| 18 | Malignant mesothelioma | Lancet, The | 2005 | 681 |
| 19 | Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 671 |
| 20 | Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers | Hepatology | 2004 | 644 |
| 21 | Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment | European Heart Journal | 2015 | 644 |
| 22 | The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma | Nature Genetics | 2011 | 617 |
| 23 | Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study | Lancet, The | 2016 | 607 |
| 24 | TRPC1 forms the stretch-activated cation channel in vertebrate cells | Nature Cell Biology | 2005 | 599 |
| 25 | A review of the clinical pharmacology of methamphetamine | Addiction | 2009 | 588 |
| 26 | Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism | Circulation | 2004 | 578 |
| 27 | Aspirin resistance | Lancet, The | 2006 | 503 |
| 28 | Extrahepatic complications of nonalcoholic fatty liver disease | Hepatology | 2014 | 478 |
| 29 | The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management | Lancet Diabetes and Endocrinology,the | 2014 | 473 |
| 30 | Fine-mapping inflammatory bowel disease loci to single-variant resolution | Nature | 2017 | 473 |
| 31 | Mechanosensitive ion channels: molecules of mechanotransduction | Journal of Cell Science | 2004 | 470 |
| 32 | Anti-PCSK9 Antibody Effectively Lowers Cholesterol in Patients With Statin Intolerance | Journal of the American College of Cardiology | 2014 | 465 |
| 33 | The Natural Course of Non-Alcoholic Fatty Liver Disease | International Journal of Molecular Sciences | 2016 | 456 |
| 34 | Integrative Molecular Characterization of Malignant Pleural Mesothelioma | Cancer Discovery | 2018 | 422 |
| 35 | Kynurenine is an endothelium-derived relaxing factor produced during inflammation | Nature Medicine | 2010 | 418 |
| 36 | Common infections in diabetes: pathogenesis, management and relationship to glycaemic control | Diabetes/Metabolism Research and Reviews | 2007 | 411 |
| 37 | Genome-wide associations for birth weight and correlations with adult disease | Nature | 2016 | 406 |
| 38 | Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure | Nature Genetics | 2011 | 403 |
| 39 | Noninvasive biomarkers in NAFLD and NASH — current progress and future promise | Nature Reviews Gastroenterology and Hepatology | 2018 | 400 |
| 40 | Impact of Epidural Analgesia on Mortality and Morbidity After Surgery | Annals of Surgery | 2014 | 395 |
| 41 | Effects of Calcium Supplementation on Clinical Fracture and Bone Structure | Archives of Internal Medicine | 2006 | 391 |
| 42 | Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA | Nature | 2007 | 376 |
| 43 | Cross-priming in health and disease | Nature Reviews Immunology | 2010 | 373 |
| 44 | NAFLD as a Risk Factor for the Development of Diabetes and the Metabolic Syndrome: An Eleven-Year Follow-up Study | American Journal of Gastroenterology | 2009 | 369 |
| 45 | Omega-3 fatty acids and inflammation | Current Atherosclerosis Reports | 2004 | 348 |
| 46 | Efficacy and Safety of Rivaroxaban Compared With Warfarin Among Elderly Patients With Nonvalvular Atrial Fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) | Circulation | 2014 | 345 |
| 47 | Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria | PLoS Genetics | 2018 | 341 |
| 48 | Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society | Clinical Infectious Diseases | 2016 | 334 |
| 49 | The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis | British Journal of Clinical Pharmacology | 2016 | 329 |
| 50 | Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men | American Journal of Clinical Nutrition | 2008 | 325 |
