| # | Title | Journal | Year | Citations |
|---|
| 1 | Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 | Cell | 2005 | 2,839 |
| 2 | Synthesizing life | Nature | 2001 | 1,537 |
| 3 | CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus | Nature | 2000 | 1,386 |
| 4 | Epigenetic Regulation by Long Noncoding RNAs | Science | 2012 | 1,159 |
| 5 | In Vitro Selection of Functional Nucleic Acids | Annual Review of Biochemistry | 1999 | 1,157 |
| 6 | Parental imprinting of the mouse H19 gene | Nature | 1991 | 1,151 |
| 7 | Pulsed contractions of an actin–myosin network drive apical constriction | Nature | 2009 | 1,089 |
| 8 | Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein | Cell | 1991 | 1,055 |
| 9 | Bacterially Speaking | Cell | 2006 | 963 |
| 10 | Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids | Annual Review of Immunology | 2014 | 957 |
| 11 | Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq | Molecular Cell | 2010 | 914 |
| 12 | Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO | Molecular Cell | 2006 | 911 |
| 13 | The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation | Cell | 1997 | 880 |
| 14 | The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer | Journal of Experimental Medicine | 2018 | 786 |
| 15 | Disruption of imprinting caused by deletion of the H19 gene region in mice | Nature | 1995 | 750 |
| 16 | Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 744 |
| 17 | Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division | Science | 2003 | 741 |
| 18 | Establishment of developmental precision and proportions in the early Drosophila embryo | Nature | 2002 | 701 |
| 19 | Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences | Nature | 2007 | 661 |
| 20 | X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease | Cell | 2013 | 631 |
| 21 | Increased anxiety of mice lacking the serotonin1A receptor | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 629 |
| 22 | Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA | Cell | 2014 | 625 |
| 23 | cGAS in action: Expanding roles in immunity and inflammation | Science | 2019 | 602 |
| 24 | Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog | Cell | 1992 | 563 |
| 25 | Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 520 |
| 26 | Functional proteins from a random-sequence library | Nature | 2001 | 506 |
| 27 | NLRX1 is a regulator of mitochondrial antiviral immunity | Nature | 2008 | 501 |
| 28 | Integration of contractile forces during tissue invagination | Journal of Cell Biology | 2010 | 495 |
| 29 | The Sins of the Fathers and Mothers | Cell | 1999 | 480 |
| 30 | Combinatorial Synthesis of Genetic Networks | Science | 2002 | 480 |
| 31 | cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila | Cell | 1995 | 477 |
| 32 | YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro | Nature | 1991 | 469 |
| 33 | YY1 Tethers Xist RNA to the Inactive X Nucleation Center | Cell | 2011 | 455 |
| 34 | X Chromosome Dosage Compensation: How Mammals Keep the Balance | Annual Review of Genetics | 2008 | 453 |
| 35 | Human cytomegalovirus IE1 and IE2 proteins block apoptosis | Journal of Virology | 1995 | 431 |
| 36 | Coupled Growth and Division of Model Protocell Membranes | Journal of the American Chemical Society | 2009 | 430 |
| 37 | The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye | Cell | 1993 | 414 |
| 38 | Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging | Molecular Cell | 2014 | 414 |
| 39 | Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 413 |
| 40 | T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20 | Nature Immunology | 2008 | 409 |
| 41 | A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing | Nature | 2020 | 409 |
| 42 | Antiviral innate immunity pathways | Cell Research | 2006 | 401 |
| 43 | A paternal–specific methylation imprint marks the alleles of the mouse H19 gene | Nature Genetics | 1995 | 396 |
| 44 | The use of mRNA display to select high-affinity protein-binding peptides | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 376 |
| 45 | Postmeiotic Sex Chromatin in the Male Germline of Mice | Current Biology | 2006 | 370 |
| 46 | Developmental Regulation of Vesicle Transport in Drosophila Embryos: Forces and Kinetics | Cell | 1998 | 368 |
| 47 | folded gastrulation, cell shape change and the control of myosin localization | Development (Cambridge) | 2005 | 367 |
| 48 | NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways | Cell | 2010 | 365 |
| 49 | Transient Homologous Chromosome Pairing Marks the Onset of X Inactivation | Science | 2006 | 361 |
| 50 | Genomic imprinting of Mash2, a mouse gene required for trophoblast development | Nature Genetics | 1995 | 359 |
