| # | Title | Journal | Year | Citations |
|---|
| 1 | Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function | Nature | 1996 | 2,855 |
| 2 | The Hippo Signaling Pathway in Development and Cancer | Developmental Cell | 2010 | 1,976 |
| 3 | Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution | Science | 2014 | 1,567 |
| 4 | Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened | Genes and Development | 2002 | 1,318 |
| 5 | The Hedgehog and Wnt signalling pathways in cancer | Nature | 2001 | 1,309 |
| 6 | Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development | Science | 1996 | 1,253 |
| 7 | Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine | Nature | 2000 | 1,243 |
| 8 | Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours | Nature | 2003 | 1,196 |
| 9 | Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer | Nature | 2003 | 1,026 |
| 10 | Hedgehog signalling in prostate regeneration, neoplasia and metastasis | Nature | 2004 | 959 |
| 11 | Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb | Cell | 2000 | 948 |
| 12 | Small molecule modulation of Smoothened activity | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 907 |
| 13 | Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling | Science | 1998 | 831 |
| 14 | Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis | Cell | 1995 | 830 |
| 15 | Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure | Science | 1989 | 790 |
| 16 | The Hedgehog Response Network: Sensors, Switches, and Routers | Science | 2004 | 784 |
| 17 | Vascular Development in the Retina and Inner Ear | Cell | 2004 | 783 |
| 18 | miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay | Science | 2012 | 765 |
| 19 | Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. | Journal of Biological Chemistry | 1987 | 725 |
| 20 | Identification of a specialized adenylyl cyclase that may mediate odorant detection | Science | 1990 | 720 |
| 21 | Patched acts catalytically to suppress the activity of Smoothened | Nature | 2002 | 711 |
| 22 | Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits | Nature | 1992 | 689 |
| 23 | A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 678 |
| 24 | A new secreted protein that binds to Wnt proteins and inhibits their activites | Nature | 1999 | 664 |
| 25 | The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals | Developmental Cell | 2010 | 663 |
| 26 | High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes | Genetics | 2015 | 600 |
| 27 | Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog | Cell | 1992 | 563 |
| 28 | The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase | Cell | 1992 | 561 |
| 29 | Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium | Journal of Biological Chemistry | 1987 | 553 |
| 30 | Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells | Science | 2003 | 511 |
| 31 | Autoproteolysis in hedgehog protein biogenesis | Science | 1994 | 505 |
| 32 | RAG Mutations in Human B Cell-Negative SCID | Science | 1996 | 504 |
| 33 | Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain | Cell | 1996 | 488 |
| 34 | The product of hedgehog autoproteolytic cleavage active in local and long-range signalling | Nature | 1995 | 483 |
| 35 | Induction of midbrain dopaminergic neurons by Sonic hedgehog | Neuron | 1995 | 447 |
| 36 | A Parsimonious Model for Gene Regulation by miRNAs | Science | 2011 | 442 |
| 37 | Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast | Nature | 1993 | 426 |
| 38 | The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program | Genes and Development | 2010 | 426 |
| 39 | Rhodopsin mutations in autosomal dominant retinitis pigmentosa. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 422 |
| 40 | Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2 | Cell | 2013 | 422 |
| 41 | Identification of a Neuropeptide Hormone That Regulates Sex Pheromone Production in Female Moths | Science | 1989 | 420 |
| 42 | A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity | Cell | 1991 | 415 |
| 43 | Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains | Nature | 2001 | 412 |
| 44 | Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal | Science | 2001 | 391 |
| 45 | Tissue/planar cell polarity in vertebrates: new insights and new questions | Development (Cambridge) | 2007 | 377 |
| 46 | Absorption spectra of human cone pigments | Nature | 1992 | 366 |
| 47 | A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis | Nature Genetics | 2003 | 363 |
| 48 | Pathway to Totipotency: Lessons from Germ Cells | Cell | 2006 | 363 |
| 49 | Hypusine-containing protein eIF5A promotes translation elongation | Nature | 2009 | 361 |
| 50 | Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin | Biochemistry | 1990 | 356 |
