| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | The Hsp70 and Hsp60 Chaperone Machines | Cell | 1998 | 2,634 |
| 4 | Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor | Cell | 1991 | 2,430 |
| 5 | ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐Wide | Current Protocols in Molecular Biology | 2015 | 2,391 |
| 6 | Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control | Cell | 1995 | 2,022 |
| 7 | De novo mutations revealed by whole-exome sequencing are strongly associated with autism | Nature | 2012 | 1,863 |
| 8 | Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb | Nature | 1998 | 1,610 |
| 9 | Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction | Cell | 2009 | 1,576 |
| 10 | SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation | Nature | 2010 | 1,388 |
| 11 | The developmental transcriptome of Drosophila melanogaster | Nature | 2011 | 1,379 |
| 12 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 13 | Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen | Science | 2008 | 1,310 |
| 14 | PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth | Science | 1996 | 1,244 |
| 15 | Non–coding RNA genes and the modern RNA world | Nature Reviews Genetics | 2001 | 1,235 |
| 16 | SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation | Cell | 2008 | 1,183 |
| 17 | Genetic diagnosis by whole exome capture and massively parallel DNA sequencing | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,167 |
| 18 | Epigenetic Regulation by Long Noncoding RNAs | Science | 2012 | 1,159 |
| 19 | Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5 | | 1998 | 1,156 |
| 20 | Membrane Fusion and Exocytosis | Annual Review of Biochemistry | 1999 | 1,136 |
| 21 | Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter | Nature Genetics | 1996 | 1,116 |
| 22 | The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus | Cell | 2009 | 1,111 |
| 23 | Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation | Molecular and Cellular Biology | 2007 | 1,097 |
| 24 | Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability | Genes and Development | 2000 | 1,087 |
| 25 | Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species | Nature Medicine | 1997 | 1,075 |
| 26 | SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells | Cell | 2006 | 1,053 |
| 27 | Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption | Science | 1999 | 1,042 |
| 28 | Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,031 |
| 29 | Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome | Nature Genetics | 1997 | 1,018 |
| 30 | Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth | Cell | 1996 | 1,014 |
| 31 | Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy | Science | 2017 | 988 |
| 32 | Electroporation and RNA interference in the rodent retina in vivo and in vitro | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 978 |
| 33 | Living with or without cyclins and cyclin-dependent kinases | Genes and Development | 2004 | 945 |
| 34 | The Promise and Perils of Wnt Signaling Through beta -Catenin | Science | 2002 | 937 |
| 35 | Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq | Molecular Cell | 2010 | 914 |
| 36 | A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene | Cell | 2009 | 912 |
| 37 | Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G1/S-Regulatory Genes | Molecular and Cellular Biology | 1995 | 871 |
| 38 | Akt regulates growth by directly phosphorylating Tsc2 | Nature Cell Biology | 2002 | 869 |
| 39 | Cooperative Regulation of Cell Polarity and Growth by Drosophila Tumor Suppressors | Science | 2000 | 867 |
| 40 | K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension | Science | 2011 | 866 |
| 41 | Vertebrate neural cell-fate determination: Lessons from the retina | Nature Reviews Neuroscience | 2001 | 859 |
| 42 | Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC | Nature Methods | 2007 | 845 |
| 43 | DNA Repair, Genome Stability, and Aging | Cell | 2005 | 824 |
| 44 | Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation | Cell | 1997 | 822 |
| 45 | The Rb/E2F pathway and cancer | Human Molecular Genetics | 2001 | 786 |
| 46 | Automated De Novo Identification of Repeat Sequence Families in Sequenced Genomes | Genome Research | 2002 | 776 |
| 47 | SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging | Cell | 2008 | 756 |
| 48 | Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1 | Nature Genetics | 1996 | 752 |
| 49 | A genome-scale shRNA resource for transgenic RNAi in Drosophila | Nature Methods | 2011 | 733 |
| 50 | Mutations in the Gene for Cardiac Myosin-Binding Protein C and Late-Onset Familial Hypertrophic Cardiomyopathy | New England Journal of Medicine | 1998 | 701 |
