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Top Articles

#TitleJournalYearCitations
1Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathwaysNature Reviews Molecular Cell Biology2009703
2Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain SynthesisMolecular Cell2014550
3Structure of the Quaternary Complex of Interleukin-2 with Its  ,  , and  c ReceptorsScience2005421
4Protein neddylation: beyond cullin–RING ligasesNature Reviews Molecular Cell Biology2015417
5Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s ModelScience2013335
6Structural Linkage between Ligand Discrimination and Receptor Activation by Type I InterferonsCell2011310
7Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signallingNature2017264
8Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategyProceedings of the National Academy of Sciences of the United States of America2015240
9Structural Mechanisms Underlying Posttranslational Modification by Ubiquitin-Like ProteinsAnnual Review of Biophysics and Biomolecular Structure2007225
10Insights into Cytokine–Receptor Interactions from Cytokine EngineeringAnnual Review of Immunology2015204
11Atomistic Autophagy: The Structures of Cellular Self-DigestionCell2014173
12Molecular Mechanisms of Fast Neurotransmitter ReleaseAnnual Review of Biophysics2018133
13Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived CardiomyocytesCell Stem Cell2020112
14The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional PlasticityImmunity201789
15Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In VivoCell Stem Cell202084
16RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexProceedings of the National Academy of Sciences of the United States of America201580
17A Novel SNARE N-terminal Domain Revealed by the Crystal Structure of Sec22bJournal of Biological Chemistry200178
18“Velcro” Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular PhagocytosisJournal of Biological Chemistry201575
19How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibioticEMBO Journal200969
20Viral E3 Ubiquitin Ligase-Mediated Degradation of a Cellular E3: Viral Mimicry of a Cellular Phosphorylation Mark Targets the RNF8 FHA DomainMolecular Cell201269
21Pathogenic Bacteria Target NEDD8-Conjugated Cullins to Hijack Host-Cell Signaling PathwaysPLoS Pathogens201066
22A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt BioavailabilityCell Reports201865
23Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selectionJournal of Experimental Medicine201052
24Use of transmission electron microscopy to identify nanocrystals of challenging protein targetsProceedings of the National Academy of Sciences of the United States of America201451
25Solution Structure of the p53 Regulatory Domain of the p19Arf Tumor Suppressor ProteinBiochemistry200144
26Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered ProteinsBiomolecules201941
27Processive ATP-driven Substrate Disassembly by the N-Ethylmaleimide-sensitive Factor (NSF) Molecular MachineJournal of Biological Chemistry201340
28The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic testActa Neuropathologica Communications201426
29Transmission electron microscopy as a tool for nanocrystal characterization pre- and post-injectorPhilosophical Transactions of the Royal Society B: Biological Sciences201423
30Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3Protein Science201320
31RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancerJCI Insight201917
32Surrogate R-spondins for tissue-specific potentiation of Wnt SignalingPLoS ONE202015
33The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activationPLoS ONE20182
34A role of autophagy in spinocerebellar ataxia—Rare exception or general principle?Autophagy20160
35Abstract LB-056: Discovery of novel small molecule inhibitors of the DCN1-Ubc12 interaction by high throughput screening technology20160