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#TitleJournalYearCitations
1Ten years of tension: single-molecule DNA mechanicsNature20031,203
2Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effectScience1992972
3Super-resolution imaging reveals distinct chromatin folding for different epigenetic statesNature2016750
4Super-resolution chromatin tracing reveals domains and cooperative interactions in single cellsScience2018700
5Analysis of Single-Molecule FRET Trajectories Using Hidden Markov ModelingBiophysical Journal2006690
6Direct Observation of the Three-State Folding of a Single Protein MoleculeScience2005587
7Structural transitions and elasticity from torque measurements on DNANature2003536
8Spatial organization of chromatin domains and compartments in single chromosomesScience2016534
9Visualizing and discovering cellular structures with super-resolution microscopyScience2018500
10Structural basis of amino acid alpha helix propensityScience1993482
11Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probesProceedings of the National Academy of Sciences of the United States of America2012439
12Photoswitching Mechanism of Cyanine DyesJournal of the American Chemical Society2009336
13Metalloaminopeptidases:  Common Functional Themes in Disparate Structural SurroundingsChemical Reviews2002326
14Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of ChromatinCell2020309
15Real-Time Imaging of Translation on Single mRNA Transcripts in Live CellsCell2016305
16The Physics of Molecular MotorsAccounts of Chemical Research2001289
17Real-Time Observation of RecA Filament Dynamics with Single Monomer ResolutionCell2006285
18Structure and function of the methionine aminopeptidasesBBA - Proteins and Proteomics2000278
19A cavity-containing mutant of T4 lysozyme is stabilized by buried benzeneNature1992269
20[7] Optical-trap force transducer that operates by direct measurement of light momentumMethods in Enzymology2003258
21A mutant T4 lysozyme displays five different crystal conformationsNature1990235
22Optical tweezers in single-molecule biophysicsNature Reviews Methods Primers2021229
23Identifying Kinetic Barriers to Mechanical Unfolding of the T. thermophila RibozymeScience2003226
24Characterization of the Early Events in Dengue Virus Cell Entry by Biochemical Assays and Single-Virus TrackingJournal of Virology2007225
25Efficient catalysis of disulphide bond rearrangements by protein disulphide isomeraseNature1993219
26The response of T4 lysozyme to large‐to‐small substitutions within the core and its relation to the hydrophobic effectProtein Science1998216
27Single-molecule derivation of salt dependent base-pair free energies in DNAProceedings of the National Academy of Sciences of the United States of America2010215
28Similar Hydrophobic Replacements of Leu99 and Phe153 within the Core of T4 Lysozyme Have Different Structural and Thermodynamic ConsequencesJournal of Molecular Biology1993213
29Toroidal Structure of -ExonucleaseScience1997213
30A structural basis for processivityProtein Science2001209
31A Structural View of the Action ofEscherichia coli(lacZ) β-Galactosidase†,‡Biochemistry2001207
32Multiple intermediates in SNARE-induced membrane fusionProceedings of the National Academy of Sciences of the United States of America2006207
33Protein Flexibility and Adaptability Seen in 25 Crystal Forms of T4 LysozymeJournal of Molecular Biology1995202
34DNA Translocation and Loop Formation Mechanism of Chromatin Remodeling by SWI/SNF and RSCMolecular Cell2006198
35Determination of α-Helix Propensity within the Context of a Folded ProteinJournal of Molecular Biology1994191
36Antiparallel EmrE exports drugs by exchanging between asymmetric structuresNature2012188
37Detection of bacteria in suspension by using a superconducting quantum interference deviceProceedings of the National Academy of Sciences of the United States of America2004184
38High resolution refinement of β‐galactosidase in a new crystal form reveals multiple metal‐binding sites and provides a structural basis for α‐complementationProtein Science2000174
39Dynamic binding orientations direct activity of HIV reverse transcriptaseNature2008171
40Accurate calculation of the density of proteinsActa Crystallographica Section D: Biological Crystallography2000167
41Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductaseProceedings of the National Academy of Sciences of the United States of America2000160
42Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopyScientific Reports2018160
43Fueling protein DNA interactions inside porous nanocontainersProceedings of the National Academy of Sciences of the United States of America2007159
44Escherichia coliMethionine Aminopeptidase:  Implications of Crystallographic Analyses of the Native, Mutant, and Inhibited Enzymes for the Mechanism of Catalysis†,‡Biochemistry1999155
45Determination of the Structure ofEscherichia coliGlyoxalase I Suggests a Structural Basis for Differential Metal Activation†Biochemistry2000154
46Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1Journal of Cell Biology2010154
47One influenza virus particle packages eight unique viral RNAs as shown by FISH analysisProceedings of the National Academy of Sciences of the United States of America2012150
48Single‐Molecule Four‐Color FRETAngewandte Chemie - International Edition2010148
49Nano-imaging with STORMNature Photonics2009146
50Structural and genetic analysis of the folding and function of T4 lysozymeFASEB Journal1996143