| # | Title | Journal | Year | Citations |
|---|
| 1 | Tumour heterogeneity and cancer cell plasticity | Nature | 2013 | 2,043 |
| 2 | The bone marrow niche for haematopoietic stem cells | Nature | 2014 | 1,910 |
| 3 | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis | Nature | 1996 | 1,789 |
| 4 | Disorders of Iron Metabolism | New England Journal of Medicine | 1999 | 1,693 |
| 5 | Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein | Science | 1997 | 1,666 |
| 6 | Endothelial and perivascular cells maintain haematopoietic stem cells | Nature | 2012 | 1,617 |
| 7 | Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome | Science | 2006 | 1,591 |
| 8 | Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 | Nature | 1991 | 1,291 |
| 9 | A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis | Cell | 2007 | 1,248 |
| 10 | Ciliopathies | New England Journal of Medicine | 2011 | 1,227 |
| 11 | Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS) | Nature Genetics | 1997 | 1,081 |
| 12 | Math1: An Essential Gene for the Generation of Inner Ear Hair Cells | Science | 1999 | 1,042 |
| 13 | Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome | Cell | 2001 | 1,033 |
| 14 | Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment | Immunity | 1995 | 1,017 |
| 15 | Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches | Nature | 2013 | 1,017 |
| 16 | Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty | Cancer Cell | 2012 | 999 |
| 17 | Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL | Nature | 1995 | 880 |
| 18 | Genetic imprinting suggested by maternal heterodisomy in non-deletion Prader-Willi syndrome | Nature | 1989 | 852 |
| 19 | Isolation of a partial candidate gene for Menkes disease by positional cloning | Nature Genetics | 1993 | 688 |
| 20 | Genetics of body-weight regulation | Nature | 2000 | 682 |
| 21 | Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 670 |
| 22 | A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis | Cell | 1998 | 622 |
| 23 | Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states | Nature Medicine | 2007 | 603 |
| 24 | The Pendred syndrome gene encodes a chloride-iodide transport protein | Nature Genetics | 1999 | 524 |
| 25 | Haematopoietic stem cells require a highly regulated protein synthesis rate | Nature | 2014 | 522 |
| 26 | Transferrin receptor is necessary for development of erythrocytes and the nervous system | Nature Genetics | 1999 | 510 |
| 27 | Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia | Nature Genetics | 2002 | 506 |
| 28 | Globin gene regulation and switching: Circa 1990 | Cell | 1990 | 497 |
| 29 | Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation | Circulation | 2010 | 478 |
| 30 | Discovery of five conserved -defensin gene clusters using a computational search strategy | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 464 |
| 31 | Neomorphic agouti mutations in obese yellow mice | Nature Genetics | 1994 | 434 |
| 32 | Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination | Cell | 2009 | 427 |
| 33 | Signaling effectors underlying pathologic growth and remodeling of the heart | Journal of Clinical Investigation | 2013 | 380 |
| 34 | The Continuing Challenge of Understanding, Preventing, and Treating Neural Tube Defects | Science | 2013 | 375 |
| 35 | Cryptic and polar variation of the fragile X repeat could result in predisposing normal alleles | Cell | 1994 | 371 |
| 36 | Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 355 |
| 37 | Iron homeostasis: insights from genetics and animal models | Nature Reviews Genetics | 2000 | 352 |
| 38 | Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling | Cell | 2012 | 347 |
| 39 | Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex | Science | 2005 | 339 |
| 40 | The genetics of pigmentation: from fancy genes to complex traits | Trends in Genetics | 1996 | 338 |
| 41 | Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice | Journal of Clinical Investigation | 2010 | 333 |
| 42 | Nephronophthisis | Journal of the American Society of Nephrology: JASN | 2009 | 332 |
| 43 | Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome | Nature Genetics | 2002 | 327 |
| 44 | Peripheral myelin protein–22 gene maps in the duplication in chromosome 17p11.2 associated with Charcot–Marie–Tooth 1A | Nature Genetics | 1992 | 325 |
| 45 | Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene | FASEB Journal | 1994 | 323 |
| 46 | Subcellular fractionation of dystrophin to the triads of skeletal muscle | Nature | 1987 | 318 |
| 47 | Development of hematopoietic cells lacking transcription factor GATA-1 | Development (Cambridge) | 1995 | 317 |
| 48 | Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes | Annals of Neurology | 2000 | 314 |
| 49 | Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis | Cell | 2014 | 314 |
| 50 | SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish | Genes and Development | 1998 | 312 |
