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Top Articles

#TitleJournalYearCitations
1X-ray structure of a protein-conducting channelNature20041,134
2DNA breaks and chromosome pulverization from errors in mitosisNature20121,051
3A Class of Membrane Proteins Shaping the Tubular Endoplasmic ReticulumCell20061,005
4Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironmentNature2009938
5A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolNature2004858
6Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranesNature2007846
7RNA-mediated epigenetic regulation of gene expressionNature Reviews Genetics2015832
8Homologous-recombination-deficient tumours are dependent on Polθ-mediated repairNature2015671
9Distinct Ubiquitin-Ligase Complexes Define Convergent Pathways for the Degradation of ER ProteinsCell2006648
10Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1 Science2006614
11Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosolJournal of Cell Biology2003542
12Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitorsNature2010525
13ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene RepressionCancer Cell2012504
14A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER NetworkCell2009495
15Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1Science2006493
16Mathematical Models of Protein Kinase Signal TransductionMolecular Cell2002461
17Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera ToxinCell2001455
18Biomechanical forces promote embryonic haematopoiesisNature2009455
19Structure of a complex of the ATPase SecA and the protein-translocation channelNature2008416
20Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription ComplexesCell2006390
21Membrane Proteins of the Endoplasmic Reticulum Induce High-Curvature TubulesScience2008386
22Polyploidy can drive rapid adaptation in yeastNature2015376
23Lin28: A MicroRNA Regulator with a Macro RoleCell2010372
24Gangliosides are receptors for murine polyoma virus and SV40EMBO Journal2003357
25Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to SenescenceCell2019347
26Deconstructing transcriptional heterogeneity in pluripotent stem cellsNature2014343
27The adipoinsular axis: effects of leptin on pancreatic β-cellsAmerican Journal of Physiology - Endocrinology and Metabolism2000335
28Protein Translocation: Tunnel VisionCell1998297
29Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative MicePLoS ONE2011283
30Origins and implications of pluripotent stem cell variability and heterogeneityNature Reviews Molecular Cell Biology2013283
31Mechanistic insights into ER-associated protein degradationCurrent Opinion in Cell Biology2018264
32Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1pCell2010262
33Molecular Mechanism of Substrate Processing by the Cdc48 ATPase ComplexCell2017254
34Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide TagJournal of Molecular Biology2014241
35Molecular Organization of a Recombinant Subviral Particle from Tick-Borne Encephalitis VirusMolecular Cell2001240
36Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporterBiochemical and Biophysical Research Communications2002216
37Structure of the L Protein of Vesicular Stomatitis Virus from Electron CryomicroscopyCell2015211
38Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ ProgenitorsDevelopmental Cell2012203
39Crystal Structure of the Long-Chain Fatty Acid Transporter FadLScience2004200
40CLASP Promotes Microtubule Rescue by Recruiting Tubulin Dimers to the MicrotubuleDevelopmental Cell2010197
41Calcium Signaling in Dendrites and Spines: Practical and Functional ConsiderationsNeuron2008196
42Repair of a DNA-Protein Crosslink by Replication-Coupled ProteolysisCell2014190
43Identification of a Prg4‐Expressing Articular Cartilage Progenitor Cell Population in MiceArthritis and Rheumatology2015185
44Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-linksScience2015183
45Functions of the retinoblastoma proteinBioEssays1999179
46Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic developmentProceedings of the National Academy of Sciences of the United States of America2009175
47Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified ComponentsCell2014175
48Variation on an Src-like ThemeCell2003173
49Structure of a bacterial homologue of vitamin K epoxide reductaseNature2010171
50Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERADCell2016169