| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | The Molecular Biology of Axon Guidance | Science | 1996 | 3,094 |
| 3 | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor | Cell | 2006 | 1,358 |
| 4 | High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity | Nature Biotechnology | 2013 | 1,303 |
| 5 | COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum | Cell | 1994 | 1,225 |
| 6 | Transcriptional activation: A complex puzzle with few easy pieces | Cell | 1994 | 1,155 |
| 7 | Mechanism of transcriptional activation by Sp1: Evidence for coactivators | Cell | 1990 | 1,088 |
| 8 | Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance | Cell | 1999 | 1,067 |
| 9 | Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates | Cell | 1999 | 1,029 |
| 10 | Coat Proteins and Vesicle Budding | Science | 1996 | 917 |
| 11 | Notch signaling: control of cell communication and cell fate | Development (Cambridge) | 2004 | 913 |
| 12 | Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase | Cell | 1991 | 890 |
| 13 | Slit Is the Midline Repellent for the Robo Receptor in Drosophila | Cell | 1999 | 866 |
| 14 | The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules | Cell | 1993 | 864 |
| 15 | CTLA-4: new insights into its biological function and use in tumor immunotherapy | Nature Immunology | 2002 | 843 |
| 16 | SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene | Cell | 1993 | 841 |
| 17 | ICOS co-stimulatory receptor is essential for T-cell activation and function | Nature | 2001 | 840 |
| 18 | Intracellular innate immune surveillance devices in plants and animals | Science | 2016 | 834 |
| 19 | BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI | Annual Review of Cell and Developmental Biology | 2004 | 815 |
| 20 | Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors | Cell | 1998 | 813 |
| 21 | Condensin-driven remodelling of X chromosome topology during dosage compensation | Nature | 2015 | 787 |
| 22 | BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 | Nature Immunology | 2003 | 768 |
| 23 | Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase | Cell | 2003 | 762 |
| 24 | The Toll and Imd pathways are the major regulators of the immune response in Drosophila | EMBO Journal | 2002 | 754 |
| 25 | Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death | Cell | 1995 | 735 |
| 26 | Applications of CRISPR technologies in research and beyond | Nature Biotechnology | 2016 | 735 |
| 27 | Mechanical Processes in Biochemistry | Annual Review of Biochemistry | 2004 | 721 |
| 28 | Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation | Cell | 1991 | 712 |
| 29 | Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins | Nature | 1990 | 691 |
| 30 | The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway | Cell | 1994 | 688 |
| 31 | Long-range and local circuits for top-down modulation of visual cortex processing | Science | 2014 | 688 |
| 32 | Genetic Analysis of Glutamate Receptors in Drosophila Reveals a Retrograde Signal Regulating Presynaptic Transmitter Release | Neuron | 1997 | 686 |
| 33 | Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571) | Cancer Research | 2002 | 684 |
| 34 | GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase | Cell | 1990 | 683 |
| 35 | The chemical repertoire of natural ribozymes | Nature | 2002 | 656 |
| 36 | Ectopic and increased expression of fasciclin II alters motoneuron growth cone guidance | Neuron | 1994 | 651 |
| 37 | Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline | Neuron | 1993 | 641 |
| 38 | Computational identification of Drosophila microRNA genes | Genome Biology | 2003 | 624 |
| 39 | Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators | Cell | 1993 | 607 |
| 40 | Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III | Neuron | 1997 | 605 |
| 41 | Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and Function | Cell | 2001 | 602 |
| 42 | Transcription from a TATA-less promoter requires a multisubunit TFIID complex. | Genes and Development | 1991 | 600 |
| 43 | Systematic determination of patterns of gene expression during Drosophila embryogenesis | Genome Biology | 2002 | 600 |
| 44 | COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes | Cell | 1998 | 590 |
| 45 | The Emerging Role of CTLA-4 as an Immune Attenuator | Immunity | 1997 | 582 |
| 46 | Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF | Science | 1995 | 577 |
| 47 | Synergistic activation by the glutamine-rich domains of human transcription factor Sp1 | Cell | 1989 | 560 |
| 48 | Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway | Genes and Development | 2003 | 557 |
| 49 | Targeted Genome Editing Across Species Using ZFNs and TALENs | Science | 2011 | 556 |
| 50 | Structural transitions and elasticity from torque measurements on DNA | Nature | 2003 | 536 |
