| # | Title | Journal | Year | Citations |
|---|
| 1 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 2 | Matrix Metalloproteinases | Journal of Biological Chemistry | 1999 | 3,558 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | Lower Extremity Function and Subsequent Disability: Consistency Across Studies, Predictive Models, and Value of Gait Speed Alone Compared With the Short Physical Performance Battery | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2000 | 2,264 |
| 5 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 6 | Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 1,804 |
| 7 | Cryptogenic Stroke and Underlying Atrial Fibrillation | New England Journal of Medicine | 2014 | 1,694 |
| 8 | Tissue inhibitors of metalloproteinases: evolution, structure and function | BBA - Proteins and Proteomics | 2000 | 1,570 |
| 9 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 10 | Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation | Cell | 2018 | 1,417 |
| 11 | Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study | Lancet, The | 2020 | 1,395 |
| 12 | Transurethral Prostatectomy: Immediate and Postoperative Complications. A Cooperative Study of 13 Participating Institutions Evaluating 3,885 Patients | Journal of Urology | 1989 | 1,384 |
| 13 | FtsZ ring structure associated with division in Escherichia coli | Nature | 1991 | 1,362 |
| 14 | Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice | Cell | 1997 | 1,307 |
| 15 | Pharmacology of oleanolic acid and ursolic acid | Journal of Ethnopharmacology | 1995 | 1,255 |
| 16 | Consensus Guidelines for the Management of Postoperative Nausea and Vomiting | Anesthesia and Analgesia | 2014 | 1,200 |
| 17 | Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications | Biochemical Pharmacology | 2011 | 1,196 |
| 18 | Iliac Crest Bone Graft Harvest Donor Site Morbidity | Spine | 1995 | 1,141 |
| 19 | Efficacy and safety of rituximab in moderately‐to‐severely active systemic lupus erythematosus: The randomized, double‐blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial | Arthritis and Rheumatism | 2010 | 1,111 |
| 20 | Hazards of Hospitalization of the Elderly | Annals of Internal Medicine | 1993 | 1,110 |
| 21 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 22 | A simplified method for the analysis of hydroxyproline in biological tissues | Clinical Biochemistry | 1996 | 1,096 |
| 23 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME | Archives of Toxicology | 2013 | 1,089 |
| 24 | Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study | Arthritis and Rheumatism | 2012 | 1,083 |
| 25 | Physical Performance Measures in the Clinical Setting | Journal of the American Geriatrics Society | 2003 | 1,078 |
| 26 | Claudins and the Modulation of Tight Junction Permeability | Physiological Reviews | 2013 | 1,043 |
| 27 | Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. | Journal of Lipid Research | 1989 | 1,029 |
| 28 | The Stroke Impact Scale Version 2.0 | Stroke | 1999 | 1,025 |
| 29 | METALLOTHIONEIN: An Intracellular Protein to Protect Against Cadmium Toxicity | Annual Review of Pharmacology and Toxicology | 1999 | 1,009 |
| 30 | Glucocorticoid-Induced Osteoporosis: Pathogenesis and Management | Annals of Internal Medicine | 1990 | 946 |
| 31 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 927 |
| 32 | Functional genomic landscape of acute myeloid leukaemia | Nature | 2018 | 907 |
| 33 | Antithrombotic Therapy for Atrial Fibrillation | Chest | 2012 | 891 |
| 34 | Subthalamic nucleus deep brain stimulation: Summary and meta-analysis of outcomes | Movement Disorders | 2006 | 811 |
| 35 | Activation mechanisms of matrix metalloproteinases | Biological Chemistry | 1997 | 807 |
| 36 | Radiographical Spinopelvic Parameters and Disability in the Setting of Adult Spinal Deformity | Spine | 2013 | 802 |
| 37 | Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review | Journal of Lipid Research | 1989 | 789 |
| 38 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 39 | A Longitudinal Investigation of Reading Outcomes in Children With Language Impairments | Journal of Speech, Language, and Hearing Research | 2002 | 771 |
| 40 | Mitophagy: mechanisms, pathophysiological roles, and analysis | Biological Chemistry | 2012 | 764 |
| 41 | 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups | Annals of the Rheumatic Diseases | 2017 | 754 |
| 42 | The dynamic genome of Hydra | Nature | 2010 | 743 |
| 43 | Sources of error with use of Goldmann-type tonometers | Survey of Ophthalmology | 1993 | 738 |
| 44 | Rasch analysis of a new stroke-specific outcome scale: the stroke impact scale11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated. | Archives of Physical Medicine and Rehabilitation | 2003 | 729 |
| 45 | Regulation of metallothionein gene expression by oxidative stress and metal ions | Biochemical Pharmacology | 2000 | 727 |
| 46 | Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 722 |
| 47 | Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity | Drug Metabolism Reviews | 2012 | 719 |
| 48 | Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With Coronavirus Disease 2019 (COVID-19) | Clinical Infectious Diseases | 2020 | 708 |
| 49 | Diabetic neuropathy | Nature Reviews Disease Primers | 2019 | 692 |
| 50 | Functional Reorganization of the Rat Motor Cortex Following Motor Skill Learning | Journal of Neurophysiology | 1998 | 688 |
