| # | Title | Journal | Year | Citations |
|---|
| 1 | Ghrelin | Molecular Metabolism | 2015 | 810 |
| 2 | Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism | Physiological Reviews | 2012 | 551 |
| 3 | Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes | Science | 2015 | 492 |
| 4 | AMPK: a metabolic gauge regulating whole-body energy homeostasis | Trends in Molecular Medicine | 2008 | 465 |
| 5 | Adipokines as emerging mediators of immune response and inflammation | Nature Clinical Practice Rheumatology | 2007 | 457 |
| 6 | Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis | Annals of the Rheumatic Diseases | 2006 | 437 |
| 7 | Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54 | Journal of Physiology | 2004 | 403 |
| 8 | TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins | Nature Communications | 2014 | 361 |
| 9 | Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes | Science | 2014 | 348 |
| 10 | Leptin, from fat to inflammation: old questions and new insights | FEBS Letters | 2005 | 337 |
| 11 | Genome of Rhodnius prolixus , an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 329 |
| 12 | The emerging role of adipokines as mediators of inflammation and immune responses | Cytokine and Growth Factor Reviews | 2007 | 316 |
| 13 | Synthesis of Leptin in Human Placenta | Endocrinology | 1997 | 305 |
| 14 | A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes | Osteoarthritis and Cartilage | 2008 | 241 |
| 15 | Hypothalamic AMPK: a canonical regulator of whole-body energy balance | Nature Reviews Endocrinology | 2016 | 227 |
| 16 | Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats | Diabetes | 2006 | 217 |
| 17 | Agouti-Related Peptide, Neuropeptide Y, and Somatostatin-Producing Neurons Are Targets for Ghrelin Actions in the Rat Hypothalamus | Endocrinology | 2003 | 209 |
| 18 | Leptin Regulation of Prepro-orexin and Orexin Receptor mRNA Levels in the Hypothalamus | Biochemical and Biophysical Research Communications | 2000 | 179 |
| 19 | A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary | PLoS ONE | 2009 | 158 |
| 20 | Endocrine-disrupting chemicals and the regulation of energy balance | Nature Reviews Endocrinology | 2017 | 152 |
| 21 | Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA | Diabetes | 2006 | 143 |
| 22 | Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat | Molecular and Cellular Endocrinology | 2006 | 139 |
| 23 | The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin | Diabetes | 2011 | 133 |
| 24 | Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action | FEBS Letters | 2003 | 129 |
| 25 | The brain and brown fat | Annals of Medicine | 2015 | 124 |
| 26 | Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty | Molecular Metabolism | 2016 | 123 |
| 27 | Gestational Profile of Leptin Messenger Ribonucleic Acid (mRNA) Content in the Placenta and Adipose Tissue in the Rat, and Regulation of the mRNA Levels of the Leptin Receptor Subtypes in the Hypothalamus During Pregnancy and Lactation1 | Biology of Reproduction | 2000 | 122 |
| 28 | Regulation of Growth Hormone Secretagogue Receptor Gene Expression in the Arcuate Nuclei of the Rat by Leptin and Ghrelin | Diabetes | 2004 | 122 |
| 29 | Novel Expression and Direct Effects of Adiponectin in the Rat Testis | Endocrinology | 2008 | 122 |
| 30 | Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi | Genome Biology | 2014 | 119 |
| 31 | Orexin Receptors Are Expressed in the Adrenal Medulla of the Rat | Endocrinology | 1999 | 116 |
| 32 | Elevated serum leptin concentrations induced by experimental acute inflammation | Life Sciences | 2000 | 116 |
| 33 | CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation | Journal of Cell Science | 2010 | 111 |
| 34 | Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin☆ | Biochemical Pharmacology | 2001 | 109 |
| 35 | Hypothalamic levels of NPY, MCH, and prepro‐orexin mRNA during pregnancy and lactation in the rat: role of prolactin | FASEB Journal | 2003 | 103 |
| 36 | Effects of Single or Repeated Intravenous Administration of Kisspeptin upon Dynamic LH Secretion in Conscious Male Rats | Endocrinology | 2006 | 102 |
| 37 | Central Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent Fashion | Endocrinology | 2008 | 102 |
| 38 | A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat | Diabetologia | 2005 | 101 |
| 39 | 1,25‐Dihydroxyvitamin D3 administration to 6‐hydroxydopamine‐lesioned rats increases glial cell line‐derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum | Journal of Neuroscience Research | 2009 | 101 |
| 40 | Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation | PLoS ONE | 2011 | 101 |
| 41 | Role of ghrelin in reproduction | Reproduction | 2007 | 99 |
| 42 | Neuroendocrine control of growth hormone secretion in humans | Trends in Endocrinology and Metabolism | 1992 | 96 |
| 43 | In-vitro anti-inflammatory effect of Eucalyptus globulus and Thymus vulgaris: nitric oxide inhibition in J774A.1 murine macrophages | Journal of Pharmacy and Pharmacology | 2010 | 96 |
| 44 | Central administration of resistin promotes short-term satiety in rats | European Journal of Endocrinology | 2005 | 93 |
| 45 | Hypothalamic mTOR pathway mediates thyroid hormone‐induced hyperphagia in hyperthyroidism | Journal of Pathology | 2012 | 93 |
| 46 | Hypothalamic Control of Lipid Metabolism: Focus on Leptin, Ghrelin and Melanocortins | Neuroendocrinology | 2011 | 90 |
| 47 | Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity | Diabetes | 2017 | 90 |
| 48 | The Endogenous Growth Hormone Secretagogue (Ghrelin) Is Synthesized and Secreted by Chondrocytes | Endocrinology | 2005 | 89 |
| 49 | Exendin-4 Potently Decreases Ghrelin Levels in Fasting Rats | Diabetes | 2007 | 89 |
| 50 | Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion | Clinical Endocrinology | 1999 | 86 |
