| # | Title | Journal | Year | Citations |
|---|
| 1 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
| 2 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 3 | Structure and function of immunoglobulins | Journal of Allergy and Clinical Immunology | 2010 | 1,322 |
| 4 | A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes | Molecular Therapy | 2010 | 1,267 |
| 5 | Etanercept Therapy in Rheumatoid Arthritis | Annals of Internal Medicine | 1999 | 1,176 |
| 6 | Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry | Annals of the Rheumatic Diseases | 2020 | 908 |
| 7 | Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry | Nature Immunology | 2019 | 760 |
| 8 | Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus | Seminars in Arthritis and Rheumatism | 2010 | 704 |
| 9 | Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome | Critical Care Medicine | 2016 | 659 |
| 10 | Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity | Nature Medicine | 2001 | 544 |
| 11 | Pathophysiology of Fibromyalgia | American Journal of Medicine | 2009 | 491 |
| 12 | Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis | Lancet, The | 2015 | 487 |
| 13 | Induction of myeloid‐derived suppressor cells by tumor exosomes | International Journal of Cancer | 2009 | 483 |
| 14 | Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW | American Journal of Medicine | 2011 | 446 |
| 15 | Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function | Journal of Immunology | 2006 | 430 |
| 16 | Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow | Immunity | 2015 | 415 |
| 17 | Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance | Diabetes | 2009 | 395 |
| 18 | Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial | Annals of the Rheumatic Diseases | 2011 | 394 |
| 19 | Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort | Annals of the Rheumatic Diseases | 2015 | 391 |
| 20 | Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses | European Journal of Immunology | 1997 | 384 |
| 21 | Dectin-2 Is a Pattern Recognition Receptor for Fungi That Couples with the Fc Receptor γ Chain to Induce Innate Immune Responses | Journal of Biological Chemistry | 2006 | 381 |
| 22 | Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells | Journal of Immunology | 2007 | 373 |
| 23 | A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases | American Journal of Human Genetics | 2001 | 338 |
| 24 | The epidemiology of glucocorticoid-associated adverse events | Current Opinion in Rheumatology | 2008 | 329 |
| 25 | EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases | Annals of the Rheumatic Diseases | 2007 | 325 |
| 26 | Systemic lupus erythematosus in three ethnic groups. XII. Risk factors for lupus nephritis after diagnosis | Lupus | 2002 | 315 |
| 27 | Three dimensional structure of human C-reactive protein | Nature Structural and Molecular Biology | 1996 | 308 |
| 28 | The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis | Arthritis and Rheumatism | 1990 | 291 |
| 29 | Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host | Blood | 2007 | 287 |
| 30 | A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus | Nature Genetics | 2008 | 277 |
| 31 | High disease activity is associated with an increased risk of infection in patients with rheumatoid arthritis | Annals of the Rheumatic Diseases | 2011 | 269 |
| 32 | Gout Medication Treatment Patterns and Adherence to Standards of Care From a Managed Care Perspective | Mayo Clinic Proceedings | 2006 | 265 |
| 33 | A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate | Annals of the Rheumatic Diseases | 2004 | 259 |
| 34 | Decay-accelerating factor modulates induction of T cell immunity | Journal of Experimental Medicine | 2005 | 259 |
| 35 | The establishment of resident memory B cells in the lung requires local antigen encounter | Nature Immunology | 2019 | 255 |
| 36 | Radiographic assessment and psychologic variables as predictors of pain and functional impairment in osteoarthritis of the knee or hip | Arthritis and Rheumatism | 1988 | 248 |
| 37 | A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death | Journal of Immunology | 2006 | 247 |
| 38 | Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee | Arthritis and Rheumatism | 1993 | 239 |
| 39 | Regulation of apoptosis proteins in cancer cells by ubiquitin | Oncogene | 2004 | 235 |
| 40 | Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles | Journal of Immunological Methods | 2001 | 234 |
| 41 | Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide | Annals of the Rheumatic Diseases | 2010 | 226 |
| 42 | Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long-term treatment | Arthritis and Rheumatism | 1989 | 221 |
| 43 | Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis | Annals of the Rheumatic Diseases | 2016 | 215 |
| 44 | Best Practices for Dual-Energy X-ray Absorptiometry Measurement and Reporting: International Society for Clinical Densitometry Guidance | Journal of Clinical Densitometry | 2016 | 214 |
| 45 | Epidemiology, risk factors, and lifestyle modifications for gout | Arthritis Research and Therapy | 2006 | 212 |
| 46 | Immunological Functions of the Omentum | Trends in Immunology | 2017 | 211 |
| 47 | Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells | American Journal of Pathology | 2010 | 200 |
| 48 | Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis | Arthritis and Rheumatism | 1976 | 199 |
| 49 | Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection | Nature Immunology | 2017 | 198 |
| 50 | Hip fracture trends in the United States, 2002 to 2015 | Osteoporosis International | 2018 | 198 |
