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Top Articles

#TitleJournalYearCitations
1Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown AdipocytesScience2010401
2Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplicationPharmacogenomics Journal2007379
3Pharmacokinetics of Opioids in Liver DiseaseClinical Pharmacokinetics1999259
4Genetic Predictors of the Clinical Response to Opioid AnalgesicsClinical Pharmacokinetics2004230
5S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1βJournal of Experimental Medicine2017216
6Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteersClinical Pharmacology and Therapeutics2003187
7Clinical Significance of Results from Olfactory TestingLaryngoscope2006173
8Different Odor Tests Contribute Differently to the Evaluation of Olfactory LossChemical Senses2008148
9Are μ-opioid receptor polymorphisms important for clinical opioid therapy?Trends in Molecular Medicine2005143
10The μ-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriersPharmacogenetics and Genomics2006137
11A Common Human μ-Opioid Receptor Genetic Variant Diminishes the Receptor Signaling Efficacy in Brain Regions Processing the Sensory Information of PainJournal of Biological Chemistry2009135
12Genetically Polymorphic OCT1: Another Piece in the Puzzle of the Variable Pharmacokinetics and Pharmacodynamics of the Opioidergic Drug TramadolClinical Pharmacology and Therapeutics2011126
13Machine learning in pain researchPain2018122
14Differential Opioid Action on Sensory and Affective Cerebral Pain ProcessingClinical Pharmacology and Therapeutics2008121
15SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemiaNature Medicine2017121
16Current evidence for a genetic modulation of the response to analgesicsPain2006113
17THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitroMolecular Immunology2017111
18Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteersPharmacogenetics and Genomics2003106
19Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centersPharmacogenetics and Genomics2009106
20Anticoagulant Therapy with the Oral Direct Factor Xa Inhibitors Rivaroxaban, Apixaban and Edoxaban and the Thrombin Inhibitor Dabigatran Etexilate in Patients with Hepatic ImpairmentClinical Pharmacokinetics2013106
21Regulation of the heat stress response inArabidopsisby MPK6-targeted phosphorylation of the heat stress factor HsfA2PeerJ2013106
22Genetic–epigenetic interaction modulates µ-opioid receptor regulationHuman Molecular Genetics2012105
23Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitutionPharmacogenetics and Genomics2009104
245,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent TerminalsJournal of Neuroscience2012103
25Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing ScreenACS Pharmacology and Translational Science2021101
26Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotypeEuropean Journal of Pain200897
27Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug actionClinical Pharmacology and Therapeutics200691
28Genetic modulation of the pharmacological treatment of pain200991
29The clinical significance of electrophysiological measures of olfactory functionBehavioural Brain Research200690
30Clinical Usefulness of Self-Rated Olfactory Performance—A Data Science-Based Assessment of 6000 PatientsChemical Senses201987
31Characterization of the Micro-Environment of the Testis that Shapes the Phenotype and Function of Testicular MacrophagesJournal of Immunology201786
32Genetic mutations that prevent pain: implications for future pain medicationPharmacogenomics200885
33Comparative clinical effects of hydromorphone and morphine: a meta-analysisBritish Journal of Anaesthesia201182
34The human μ-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation.Behavioral Neuroscience200680
35Relevance of frequent μ-opioid receptor polymorphisms for opioid activity in healthy volunteersPharmacogenomics Journal200680
36Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic painProceedings of the National Academy of Sciences of the United States of America201679
37Fatal Respiratory Depression after??Multiple Intravenous Morphine InjectionsClinical Pharmacokinetics200675
38Lipoxin and resolvin biosynthesis is dependent on 5‐lipoxygenase activating proteinFASEB Journal201570
39Macrophages programmed by apoptotic cells promote angiogenesisviaprostaglandin E2FASEB Journal201169
40Separating brain processing of pain fromthat of stimulus intensityHuman Brain Mapping201269
41A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic SteatohepatitisJournal of Medicinal Chemistry201769
42Evidence for morphine-independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolitesClinical Pharmacology and Therapeutics200668
43Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?Pain200968
44Common non-epigenetic drugs as epigenetic modulatorsTrends in Molecular Medicine201368
45Machine-learned cluster identification in high-dimensional dataJournal of Biomedical Informatics201768
46IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T CellsCell Reports201968
47A GTP cyclohydrolase 1 genetic variant delays cancer painPain201067
48Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responsesDiabetologia201464
49Computed ABC Analysis for Rational Selection of Most Informative Variables in Multivariate DataPLoS ONE201564
50PGD2 metabolism in plasma: Kinetics and relationship with bioactivity on DP1 and CRTH2 receptorsBiochemical Pharmacology200763