| # | Title | Journal | Year | Citations |
|---|
| 1 | Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate‐liganded heme protein that hydroxylates L‐arginine to produce NO as a cellular signal | FASEB Journal | 1996 | 203 |
| 2 | Protective role of selenium against renal toxicity induced by cadmium in rats | Toxicology | 2007 | 176 |
| 3 | The hepatoprotective effects of selenium against cadmium toxicity in rats | Toxicology | 2007 | 142 |
| 4 | Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA | Molecular and Cellular Biology | 2001 | 124 |
| 5 | Acute intoxication of deltamethrin in monosex Nile tilapia, Oreochromis niloticus with special reference to the clinical, biochemical and haematological effects | Environmental Toxicology and Pharmacology | 2007 | 122 |
| 6 | Biochemical study on the effects of some Egyptian herbs in alloxan-induced diabetic rats | Toxicology | 2002 | 114 |
| 7 | Propolis alleviates aluminium-induced lipid peroxidation and biochemical parameters in male rats | Food and Chemical Toxicology | 2009 | 112 |
| 8 | Hepato-renal toxicity of oral sub-chronic exposure to aluminum oxide and/or zinc oxide nanoparticles in rats | Toxicology Reports | 2019 | 90 |
| 9 | Potential Urinary miRNA Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients | Journal of Cancer | 2014 | 88 |
| 10 | Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase | European Journal of Medicinal Chemistry | 2019 | 78 |
| 11 | Apurinic/apyrimidinic endonuclease 1 is a key modulator of aluminum-induced neuroinflammation | BMC Neuroscience | 2013 | 76 |
| 12 | Differential metformin dose-dependent effects on cognition in rats: role of Akt | Psychopharmacology | 2016 | 75 |
| 13 | Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma | Journal of Controlled Release | 2018 | 75 |
| 14 | Simultaneous multiresidue determination of metronidazole and spiramycin in fish muscle using high performance liquid chromatography with UV detection | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | 2008 | 74 |
| 15 | Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines | Breast | 2018 | 72 |
| 16 | Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats | Toxicology | 2002 | 71 |
| 17 | Biosorption of lead and cadmium using marine algae | Chemistry and Ecology | 2011 | 64 |
| 18 | Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells | Cancer Biology and Therapy | 2009 | 63 |
| 19 | Cypermethrin induced damage in genomic DNA and histopathological changes in brain and haematotoxicity in rats: The protective effect of sesame oil | Brain Research Bulletin | 2013 | 60 |
| 20 | Chicory (Cichorium intybus L.) Root Extract Regulates the Oxidative Status and Antioxidant Gene Transcripts in CCl4-Induced Hepatotoxicity | PLoS ONE | 2015 | 60 |
| 21 | Antimicrobial textile treated with chitosan from Aspergillus niger mycelial waste | International Journal of Biological Macromolecules | 2011 | 59 |
| 22 | Chemical characterization, antioxidant and anti-inflammatory properties of Greek Thymus vulgaris extracts and their possible synergism with Egyptian Chlorella vulgaris | Journal of Functional Foods | 2018 | 57 |
| 23 | Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats | Food and Chemical Toxicology | 2010 | 56 |
| 24 | Spirulina platensis prevents hyperglycemia in rats by modulating gluconeogenesis and apoptosis via modification of oxidative stress and MAPK-pathways | Biomedicine and Pharmacotherapy | 2017 | 56 |
| 25 | Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetes Mellitus in Rats: Role ofAlhagi maurorumExtracts | Oxidative Medicine and Cellular Longevity | 2016 | 55 |
| 26 | Wheat biological responses to stress caused by cadmium, nickel and lead | Science of the Total Environment | 2020 | 55 |
| 27 | Neurohepatic toxicity of subacute manganese chloride exposure and potential chemoprotective effects of lycopene | NeuroToxicology | 2012 | 54 |
| 28 | Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles | Metabolic Brain Disease | 2017 | 52 |
| 29 | Evaluation of Pesticide Residues in Vegetables from the Asir Region, Saudi Arabia | Molecules | 2020 | 50 |
| 30 | Dual-Targeted Lactoferrin Shell-Oily Core Nanocapsules for Synergistic Targeted/Herbal Therapy of Hepatocellular Carcinoma | ACS Applied Materials & Interfaces | 2019 | 49 |
| 31 | Prevalence of Aflatoxins in Blood and Urine of Egyptian Infants with Protein–Energy Malnutrition | Food and Nutrition Bulletin | 2005 | 48 |
| 32 | In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris | BMC Complementary and Alternative Medicine | 2018 | 48 |
| 33 | Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells | Endocrine | 2015 | 46 |
| 34 | Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers | PLoS ONE | 2019 | 46 |
| 35 | Oestrogen content of pomegranate seeds | Journal of Chromatography A | 1988 | 45 |
| 36 | Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction | Metabolic Brain Disease | 2011 | 45 |
| 37 | Melatonin mitigates thioacetamide-induced hepatic fibrosis via antioxidant activity and modulation of proinflammatory cytokines and fibrogenic genes | Life Sciences | 2018 | 44 |
| 38 | Effects of Lipoic Acid on Acrylamide Induced Testicular Damage | Materia Socio-medica | 2014 | 43 |
| 39 | Similar and Additive Effects of Ovariectomy and Diabetes on Insulin Resistance and Lipid Metabolism | Biochemistry Research International | 2015 | 43 |
| 40 | Synthetic organic food colouring agents and their degraded products: effects on human and rat cholinesterases | British Journal of Biomedical Science | 2004 | 42 |
| 41 | Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats | Neuroscience Letters | 2008 | 42 |
| 42 | Thiamethoxam induced hepatotoxicity and pro-carcinogenicity in rabbits via motivation of oxidative stress, inflammation, and anti-apoptotic pathway | Environmental Science and Pollution Research | 2018 | 42 |
| 43 | Deleterious effects of cypermethrin on rat liver and kidney: Protective role of sesame oil | Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes | 2012 | 41 |
| 44 | Schizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(α)anthracene and decreases cell proliferation: comparison with tamoxifen | Journal of Cancer Research and Clinical Oncology | 2012 | 41 |
| 45 | Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug | PLoS ONE | 2015 | 41 |
| 46 | Trigonella foenum(Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen | BioMed Research International | 2015 | 41 |
| 47 | A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats | Journal of Alzheimer's Disease | 2017 | 40 |
| 48 | Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation | Molecular and Cellular Biochemistry | 2016 | 39 |
| 49 | Effect of selenium supplementation on the activities of glutathione metabolizing enzymes in human hepatoma Hep G2 cell line | Toxicology | 2000 | 38 |
| 50 | Potential role of α-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats | Life Sciences | 2018 | 38 |
