| # | Title | Journal | Year | Citations |
|---|
| 1 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 2 | Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients | Food and Chemical Toxicology | 2007 | 1,336 |
| 3 | Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems | European Journal of Pharmaceutical Sciences | 2000 | 942 |
| 4 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 5 | The pilocarpine model of temporal lobe epilepsy | Journal of Neuroscience Methods | 2008 | 834 |
| 6 | Structural insights into µ-opioid receptor activation | Nature | 2015 | 743 |
| 7 | The heme synthesis and degradation pathways: role in oxidant sensitivity | Free Radical Biology and Medicine | 2000 | 710 |
| 8 | The Epidemiology of Guillain-Barré Syndrome Worldwide | Neuroepidemiology | 2009 | 469 |
| 9 | Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition | Endocrine Reviews | 2005 | 458 |
| 10 | The incidence of primary glomerulonephritis worldwide: a systematic review of the literature | Nephrology Dialysis Transplantation | 2011 | 452 |
| 11 | Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle | Immunology | 2004 | 432 |
| 12 | Chemokines and T Lymphocytes | Immunity | 1998 | 401 |
| 13 | Long non-coding RNAs in the regulation of the immune response | Trends in Immunology | 2014 | 389 |
| 14 | Biofilms and antibiotic therapy: Is there a role for combating bacterial resistance by the use of novel drug delivery systems? | Advanced Drug Delivery Reviews | 2005 | 381 |
| 15 | Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling | Journal of Biological Chemistry | 2004 | 370 |
| 16 | The cancer chemopreventive actions of phytochemicals derived from glucosinolates | European Journal of Nutrition | 2008 | 340 |
| 17 | Key issues in non-viral gene delivery1PII of original article: S0169-409X(98)00048-9. The article was originally published in Advanced Drug Delivery Reviews 34 (1998) 3–19.1 | Advanced Drug Delivery Reviews | 2001 | 324 |
| 18 | Endosomes: A legitimate platform for the signaling train | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 317 |
| 19 | Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose | Nature | 1999 | 316 |
| 20 | Mathematical models of skin permeability: An overview | International Journal of Pharmaceutics | 2011 | 294 |
| 21 | Myositis‐specific autoantibodies: an important tool to support diagnosis of myositis | Journal of Internal Medicine | 2016 | 285 |
| 22 | Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes | Nature Communications | 2014 | 281 |
| 23 | Intestinal permeation enhancers for oral peptide delivery | Advanced Drug Delivery Reviews | 2016 | 266 |
| 24 | Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing | Gastroenterology | 2005 | 262 |
| 25 | Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing | Gastroenterology | 2005 | 259 |
| 26 | Autoantibodies in myositis | Nature Reviews Rheumatology | 2018 | 248 |
| 27 | Combating Sale of Counterfeit and Falsified Medicines Online: A Losing Battle | Frontiers in Pharmacology | 2017 | 246 |
| 28 | Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform | Nature Nanotechnology | 2018 | 242 |
| 29 | Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids | Journal of Controlled Release | 1998 | 234 |
| 30 | Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation | British Journal of Pharmacology | 2008 | 227 |
| 31 | Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor | Clinical Cancer Research | 2006 | 225 |
| 32 | Key issues in non-viral gene delivery | Advanced Drug Delivery Reviews | 1998 | 219 |
| 33 | Do patients have worse outcomes in heart failure than in cancer? A primary care‐based cohort study with 10‐year follow‐up in Scotland | European Journal of Heart Failure | 2017 | 213 |
| 34 | Spatial separation of endothelial small‐ and intermediate‐conductance calcium‐activated potassium channels (KCa) and connexins: possible relationship to vasodilator function? | Journal of Anatomy | 2006 | 209 |
| 35 | Chemokines: understanding their role in T-lymphocyte biology | Biochemical Journal | 1998 | 202 |
| 36 | Modulation of Endothelial Cell K Ca 3.1 Channels During Endothelium-Derived Hyperpolarizing Factor Signaling in Mesenteric Resistance Arteries | Circulation Research | 2008 | 198 |
| 37 | Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate | Structure | 1999 | 197 |
| 38 | Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity | Nature Chemistry | 2012 | 197 |
| 39 | The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes | Journal of Immunology | 1999 | 195 |
| 40 | Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) | Blood | 2007 | 188 |
| 41 | Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients | Journal of Autoimmunity | 2019 | 184 |
| 42 | Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling | British Journal of Pharmacology | 2020 | 182 |
| 43 | The Incidence of Myasthenia Gravis: A Systematic Literature Review | Neuroepidemiology | 2010 | 179 |
| 44 | The incidence of autoimmune thyroid disease: a systematic review of the literature | Clinical Endocrinology | 2008 | 178 |
| 45 | Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity | Science | 2013 | 175 |
| 46 | The Influence of Fine Excipient Particles on the Performance of Carrier-Based Dry Powder Inhalation Formulations | Pharmaceutical Research | 2006 | 172 |
| 47 | Insights into the activation mechanism of class I HDAC complexes by inositol phosphates | Nature Communications | 2016 | 172 |
| 48 | The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes | Journal of Immunology | 1999 | 170 |
| 49 | Small‐ and Intermediate‐Conductance Calcium‐Activated K+ Channels Provide Different Facets of Endothelium‐Dependent Hyperpolarization in Rat Mesenteric Artery | Journal of Physiology | 2003 | 167 |
| 50 | Rapid Endothelial Cell–Selective Loading of Connexin 40 Antibody Blocks Endothelium-Derived Hyperpolarizing Factor Dilation in Rat Small Mesenteric Arteries | Circulation Research | 2005 | 167 |
