| # | Title | Journal | Year | Citations |
|---|
| 1 | JNK signaling in apoptosis | Oncogene | 2008 | 1,259 |
| 2 | Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia | Nature Genetics | 1999 | 711 |
| 3 | Modulation of life and death by the TNF receptor superfamily | Oncogene | 1998 | 497 |
| 4 | TAMeless traitors: macrophages in cancer progression and metastasis | British Journal of Cancer | 2017 | 471 |
| 5 | The myb gene family in cell growth, differentiation and apoptosis | Oncogene | 1999 | 456 |
| 6 | Janus kinases: components of multiple signaling pathways | Oncogene | 2000 | 423 |
| 7 | Liver stem cells and hepatocellular carcinoma | Hepatology | 2009 | 291 |
| 8 | Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study | Lancet Oncology, The | 2015 | 249 |
| 9 | Hematopoietic cytokine receptor signaling | Oncogene | 2007 | 233 |
| 10 | Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 226 |
| 11 | T Cell Dysfunction and Exhaustion in Cancer | Frontiers in Cell and Developmental Biology | 2020 | 226 |
| 12 | PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 220 |
| 13 | Arrest of spermatogenesis and defective breast development in mice lacking A-myb | Nature | 1997 | 213 |
| 14 | IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled | Oncogene | 2000 | 205 |
| 15 | Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain | Oncogene | 1993 | 204 |
| 16 | Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13 | Journal of Biological Chemistry | 1995 | 168 |
| 17 | Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial | Lancet Oncology, The | 2017 | 148 |
| 18 | Clinical and translational advances in esophageal squamous cell carcinoma | Advances in Cancer Research | 2019 | 140 |
| 19 | Regulation of cell proliferation by G proteins | Oncogene | 1998 | 137 |
| 20 | JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 137 |
| 21 | The promise of epigenetic therapy: reprogramming the cancer epigenome | Current Opinion in Genetics and Development | 2017 | 136 |
| 22 | Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo | Journal of Cell Biology | 2006 | 117 |
| 23 | Gadd45 Stress Sensors in Malignancy and Leukemia | Critical Reviews in Oncogenesis | 2011 | 117 |
| 24 | Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation | Oncogene | 2007 | 113 |
| 25 | The Interferon-Gamma Paradox in Cancer | Journal of Interferon and Cytokine Research | 2019 | 112 |
| 26 | TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer | Cancer Research | 2018 | 109 |
| 27 | Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy | Cell Death and Differentiation | 2013 | 107 |
| 28 | Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis | Cancer Cell | 2019 | 107 |
| 29 | Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells | Blood | 2013 | 105 |
| 30 | Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties | Scientific Reports | 2013 | 104 |
| 31 | Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity | Nature Communications | 2017 | 99 |
| 32 | Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 98 |
| 33 | Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4 | Cancer Research | 2018 | 96 |
| 34 | Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice | Oncogene | 2003 | 95 |
| 35 | TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia | Cancer Research | 2015 | 80 |
| 36 | Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates | Science Advances | 2021 | 80 |
| 37 | Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression | Cancer Research | 2019 | 77 |
| 38 | Age-related epigenetic drift in the pathogenesis of MDS and AML | Genome Research | 2014 | 76 |
| 39 | Epigenetic changes and assisted reproductive technologies | Epigenetics | 2020 | 75 |
| 40 | Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition | Genome Biology | 2013 | 74 |
| 41 | Epigenetics and Precision Oncology | Cancer Journal (Sudbury, Mass ) | 2017 | 73 |
| 42 | Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial | Lancet Haematology,the | 2019 | 71 |
| 43 | Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation | Oncogene | 2000 | 70 |
| 44 | AATYK: A novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells | Oncogene | 1997 | 68 |
| 45 | Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling | Nature Cell Biology | 2020 | 67 |
| 46 | Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion | Journal of Neuroscience | 2018 | 66 |
| 47 | Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis | Nature Communications | 2020 | 65 |
| 48 | Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms | Blood | 2017 | 64 |
| 49 | Genetically engineered mouse models of melanoma | Cancer | 2017 | 62 |
| 50 | Differentiation primary response genes and proto‐oncogenes as positive and negative regulators of terminal hematopoietic cell differentiation | Stem Cells | 1994 | 61 |
