| # | Title | Journal | Year | Citations |
|---|
| 1 | Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal | Trends in Pharmacological Sciences | 2008 | 473 |
| 2 | Biology of Intracranial Aneurysms: Role of Inflammation | Journal of Cerebral Blood Flow and Metabolism | 2012 | 403 |
| 3 | Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 301 |
| 4 | Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology | Cardiovascular Research | 2018 | 284 |
| 5 | Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis | Nature Communications | 2019 | 280 |
| 6 | Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy | Annals of the New York Academy of Sciences | 2008 | 272 |
| 7 | Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease | Nature Communications | 2019 | 224 |
| 8 | New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging | Frontiers in Pharmacology | 2018 | 199 |
| 9 | Molecular cloning and expression of a rat κ opioid receptor | Biochemical Journal | 1993 | 188 |
| 10 | Orexin/hypocretin role in reward: implications for opioid and other addictions | British Journal of Pharmacology | 2015 | 149 |
| 11 | Endothelial cell CD36 optimizes tissue fatty acid uptake | Journal of Clinical Investigation | 2018 | 148 |
| 12 | Teratogenic potential of cocaine hydrochloride in CF-1 mice | Journal of Pharmaceutical Sciences | 1980 | 143 |
| 13 | Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival | American Journal of Physiology - Heart and Circulatory Physiology | 2011 | 143 |
| 14 | Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts | Journal of Neurochemistry | 2001 | 134 |
| 15 | The Quality of Reporting of Randomized Controlled Trials of Traditional Chinese Medicine: A Survey of 13 Randomly Selected Journals from Mainland China | Clinical Therapeutics | 2007 | 132 |
| 16 | Ceruloplasmin/Hephaestin Knockout Mice Model Morphologic and Molecular Features of AMD | | 2008 | 117 |
| 17 | Immune cell subset differentiation and tissue inflammation | Journal of Hematology and Oncology | 2018 | 116 |
| 18 | EFFICIENT DESIGNS FOR STUDYING SYNERGISTIC DRUG COMBINATIONS | Life Sciences | 1997 | 113 |
| 19 | Comparison of Agonist-Induced Internalization of the Human EP2 and EP4 Prostaglandin Receptors: Role of the Carboxyl Terminus in EP4 Receptor Sequestration | Molecular Pharmacology | 2000 | 109 |
| 20 | MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease | Journal of Biological Chemistry | 2017 | 107 |
| 21 | Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival | Cardiovascular Research | 2007 | 106 |
| 22 | Cell Electrophysiology with Carbon Nanopipettes | ACS Nano | 2009 | 101 |
| 23 | The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration | | 2011 | 101 |
| 24 | Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis | Cardiovascular Research | 2017 | 101 |
| 25 | Homocysteine exacerbates β‐amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles | Annals of Neurology | 2014 | 100 |
| 26 | Two-pore channels provide insight into the evolution of voltage-gated Ca 2+ and Na + channels | Science Signaling | 2014 | 98 |
| 27 | Isolation and Characterization of EMS16, a C-Lectin Type Protein from Echis multisquamatus Venom, a Potent and Selective Inhibitor of the α2β1 Integrin | Biochemistry | 2000 | 97 |
| 28 | Agonist-induced regulation and trafficking of $kappa; opioid receptors | Life Sciences | 2004 | 96 |
| 29 | 6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment | Journal of Biological Chemistry | 2012 | 96 |
| 30 | Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice | Molecular Neurodegeneration | 2012 | 96 |
| 31 | Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study | Journal of Hematology and Oncology | 2016 | 92 |
| 32 | G protein-coupled receptor kinases as therapeutic targets in the heart | Nature Reviews Cardiology | 2019 | 90 |
| 33 | 5‐lipoxygenase as an endogenous modulator of amyloid beta formation in vivo | Annals of Neurology | 2011 | 87 |
| 34 | Mitochondrial ROS, uncoupled from ATP synthesis, determine endothelial activation for both physiological recruitment of patrolling cells and pathological recruitment of inflammatory cells | Canadian Journal of Physiology and Pharmacology | 2017 | 87 |
| 35 | Circadian rhythm dysfunction: a novel environmental risk factor for Parkinson’s disease | Molecular Psychiatry | 2017 | 85 |
| 36 | Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia | Journal of Neuroscience Research | 2009 | 83 |
| 37 | Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function | JCI Insight | 2017 | 83 |
| 38 | Neuropharmacology of St. John's Wort (Hypericum) | Annals of Pharmacotherapy | 1998 | 82 |
| 39 | microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases | Frontiers in Medicine | 2017 | 80 |
| 40 | Heteromeric Complexes of alpha5 and/or alpha7 Subunits: Effects of Calcium and Potential Role in Nicotine-Induced Presynaptic Facilitation | Annals of the New York Academy of Sciences | 1999 | 79 |
| 41 | Krüppel-Like Factors | JACC Basic To Translational Science | 2018 | 78 |
| 42 | Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model | American Journal of Pathology | 2011 | 77 |
| 43 | G Protein–Coupled Receptor Kinase 2 | Circulation Research | 2014 | 77 |
| 44 | HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction | Science Translational Medicine | 2020 | 75 |
| 45 | Drug Combinations: Tests and Analysis with Isoboles | Current Protocols in Pharmacology | 2016 | 74 |
| 46 | Acceleration of brain amyloidosis in an Alzheimer’s disease mouse model by a folate, vitamin B6 and B12-deficient diet | Experimental Gerontology | 2010 | 73 |
| 47 | Vitamin E in aging, dementia, and Alzheimer's disease | BioFactors | 2012 | 73 |
| 48 | Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder | Biological Psychiatry | 2015 | 69 |
| 49 | Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases | Cancer and Metastasis Reviews | 2018 | 69 |
| 50 | Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model | Translational Psychiatry | 2017 | 68 |
