| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer | Autophagy | 2010 | 394 |
| 3 | NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA† | Biochemistry | 1998 | 369 |
| 4 | Natural‐Product Sugar Biosynthesis and Enzymatic Glycodiversification | Angewandte Chemie - International Edition | 2008 | 363 |
| 5 | Localization of distinct monoamine oxidase a and monoamine oxidase b cell populations in human brainstem | Neuroscience | 1988 | 335 |
| 6 | Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A | Nature | 2011 | 265 |
| 7 | Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis | Annual Review of Biochemistry | 2013 | 248 |
| 8 | G-quadruplexes as targets for drug design | Annual Review of Biochemistry | 2000 | 199 |
| 9 | Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule | Journal of Biological Chemistry | 2001 | 184 |
| 10 | Virtual screening using molecular simulations | Proteins: Structure, Function and Bioinformatics | 2011 | 171 |
| 11 | Accelerated Assembly of G-Quadruplex Structures by a Small Molecule | Biochemistry | 1999 | 164 |
| 12 | B1-Metallo-β-Lactamases: Where Do We Stand? | Current Drug Targets | 2016 | 158 |
| 13 | Molecular basis for sequence-specific DNA alkylation by CC-1065 | Biochemistry | 1988 | 156 |
| 14 | The Diverse Roles of Flavin CoenzymesNature's Most Versatile Thespians | Journal of Organic Chemistry | 2007 | 156 |
| 15 | Histone Citrullination by Protein Arginine Deiminase: Is Arginine Methylation a Green Light or a Roadblock? | ACS Chemical Biology | 2006 | 153 |
| 16 | Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2′-hydroxyphenyl)benzoxazole analogs of UK-1 | Bioorganic and Medicinal Chemistry | 2008 | 153 |
| 17 | Formation of Unusual Sugars: Mechanistic Studies and Biosynthetic Applications | Annual Review of Biochemistry | 2002 | 151 |
| 18 | Pluramycins. Old Drugs Having Modern Friends in Structural Biology | Accounts of Chemical Research | 1996 | 143 |
| 19 | Identification of the ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications | Journal of the American Chemical Society | 2009 | 141 |
| 20 | Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs | Journal of Biological Chemistry | 2008 | 130 |
| 21 | Enoyl-CoA hydratase | Bioorganic and Medicinal Chemistry | 2003 | 129 |
| 22 | The Quorum-Quenching Lactonase fromBacillus thuringiensisIs a Metalloprotein† | Biochemistry | 2005 | 124 |
| 23 | Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines | Journal of Medicinal Chemistry | 1990 | 118 |
| 24 | Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 117 |
| 25 | Characterization of Purified New Delhi Metallo-β-lactamase-1 | Biochemistry | 2011 | 114 |
| 26 | New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity | European Journal of Medicinal Chemistry | 2009 | 112 |
| 27 | Reversal of the Apparent Regiospecificity of NAD(P)H-Dependent Hydride Transfer: The Properties of the Difluoromethylene Group, A Carbonyl Mimic | Journal of the American Chemical Society | 2003 | 111 |
| 28 | GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme | Journal of the American Chemical Society | 2013 | 110 |
| 29 | Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53 | Journal of Biological Chemistry | 2011 | 109 |
| 30 | Current development in isoprenoid precursor biosynthesis and regulation | Current Opinion in Chemical Biology | 2013 | 109 |
| 31 | Self-Assembly of a Quinobenzoxazine-Mg2+ Complex on DNA: A New Paradigm for the Structure of a Drug-DNA Complex and Implications for the Structure of the Quinolone Bacterial Gyrase-DNA Complex | Journal of Medicinal Chemistry | 1995 | 104 |
| 32 | The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition | Nature Chemical Biology | 2015 | 101 |
| 33 | Protein Purification and Function Assignment of the Epoxidase Catalyzing the Formation of Fosfomycin | Journal of the American Chemical Society | 2001 | 97 |
| 34 | Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer | PLoS ONE | 2012 | 95 |
| 35 | Molecular characterization of monoamine oxidases A and B | Progress in Molecular Biology and Translational Science | 2000 | 94 |
| 36 | Mechanistic Investigation of UDP-Galactopyranose Mutase from Escherichia coli Using 2- and 3-Fluorinated UDP-Galactofuranose as Probes | Journal of the American Chemical Society | 2001 | 89 |
| 37 | Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides | Journal of the American Chemical Society | 2015 | 89 |
| 38 | Characterization of the Glycosyltransferase Activity of DesVII: Analysis of and Implications for the Biosynthesis of Macrolide Antibiotics | Journal of the American Chemical Society | 2004 | 87 |
| 39 | The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation | PLoS ONE | 2011 | 87 |
| 40 | N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA | Journal of the American Chemical Society | 2015 | 86 |
| 41 | The chemical versatility of the β–α–β fold: Catalytic promiscuity and divergent evolution in the tautomerase superfamily | Cellular and Molecular Life Sciences | 2008 | 85 |
| 42 | Perylene Diimide G-Quadruplex DNA Binding Selectivity is Mediated by Ligand Aggregation | Bioorganic and Medicinal Chemistry Letters | 2002 | 82 |
| 43 | Mechanisms of enzymatic CO bond cleavages in deoxyhexose biosynthesis | Current Opinion in Chemical Biology | 2002 | 78 |
| 44 | Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C) | Biochemical Pharmacology | 2002 | 77 |
| 45 | Bacillomycin Lc, a New Antibiotic of the Iturin Group: Isolation, Structures, and Antifungal Activities of the Congeners. | Journal of Antibiotics | 1995 | 76 |
| 46 | Domain C of Human Poly(ADP-ribose) Polymerase-1 Is Important for Enzyme Activity and Contains a Novel Zinc-Ribbon Motif, | Biochemistry | 2008 | 75 |
| 47 | In Vitro Characterization of the Enzymes Involved in TDP-d-Forosamine Biosynthesis in the Spinosyn Pathway of Saccharopolyspora spinosa | Journal of the American Chemical Society | 2008 | 75 |
| 48 | The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars | Chemical Society Reviews | 2013 | 75 |
| 49 | The total synthesis of UK-1 | Tetrahedron Letters | 1997 | 72 |
| 50 | Dopamine depletion and subsequent treatment with l-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum | Journal of Neurochemistry | 2007 | 72 |
