| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel | Blood | 2017 | 4,375 |
| 3 | Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update | Hepatology International | 2016 | 1,908 |
| 4 | Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update | Hepatology International | 2017 | 1,537 |
| 5 | Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis | American Journal of Pathology | 2010 | 1,281 |
| 6 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 7 | Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN | Blood | 2022 | 805 |
| 8 | MicroRNA Signature Predicts Survival and Relapse in Lung Cancer | Cancer Cell | 2008 | 754 |
| 9 | Ulcerative colitis | Nature Reviews Disease Primers | 2020 | 678 |
| 10 | A Novel Virulence Gene in Klebsiella pneumoniae Strains Causing Primary Liver Abscess and Septic Metastatic Complications | Journal of Experimental Medicine | 2004 | 609 |
| 11 | Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians | Nature Genetics | 2012 | 545 |
| 12 | Klebsiella pneumoniae Genotype K1: An Emerging Pathogen That Causes Septic Ocular or Central Nervous System Complications from Pyogenic Liver Abscess | Clinical Infectious Diseases | 2007 | 529 |
| 13 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis | Gut | 2013 | 497 |
| 14 | Hepatitis B virus infection | Nature Reviews Disease Primers | 2018 | 490 |
| 15 | Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer | Molecular Cancer | 2018 | 489 |
| 16 | Value of sonography in determining the nature of pleural effusion: analysis of 320 cases. | American Journal of Roentgenology | 1992 | 453 |
| 17 | Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2019 | 418 |
| 18 | p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug | Nature Cell Biology | 2009 | 414 |
| 19 | Effectiveness of Tyrosine Kinase Inhibitors on “Uncommon” Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non–Small Cell Lung Cancer | Clinical Cancer Research | 2011 | 413 |
| 20 | Synthetic Peroxisome Proliferator-Activated Receptor- Agonist, Rosiglitazone, Increases Plasma Levels of Adiponectin in Type 2 Diabetic Patients | Diabetes Care | 2002 | 392 |
| 21 | Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis | Journal of the American College of Cardiology | 2017 | 356 |
| 22 | Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation | Circulation | 2004 | 343 |
| 23 | Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis | Lancet Neurology, The | 2005 | 330 |
| 24 | Update of pathophysiology and management of diabetic kidney disease | Journal of the Formosan Medical Association | 2018 | 325 |
| 25 | Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms | Frontiers in Pharmacology | 2019 | 320 |
| 26 | AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations | Blood | 2009 | 318 |
| 27 | Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Update on Therapeutic Options | Frontiers in Microbiology | 2019 | 313 |
| 28 | The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells | Cancer Cell | 2006 | 308 |
| 29 | Asia Pacific consensus recommendations for colorectal cancer screening | Gut | 2008 | 307 |
| 30 | Deep neck infection: Analysis of 185 cases | Head and Neck | 2004 | 305 |
| 31 | Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: a cohort study in arseniasis-hyperendemic villages in Taiwan. | Environmental Health Perspectives | 2000 | 302 |
| 32 | A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese | PLoS Genetics | 2010 | 301 |
| 33 | Genome Sequencing and Comparative Analysis ofKlebsiella pneumoniaeNTUH-K2044, a Strain Causing Liver Abscess and Meningitis | Journal of Bacteriology | 2009 | 300 |
| 34 | Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Mutations Is Associated with Poor Gefitinib Treatment Response | Clinical Cancer Research | 2008 | 294 |
| 35 | Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death | Gastroenterology | 2010 | 289 |
| 36 | Habitual Sleep Duration and Insomnia and the Risk of Cardiovascular Events and All-cause Death: Report from a Community-Based Cohort | Sleep | 2010 | 286 |
| 37 | Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia | Nature Genetics | 2012 | 286 |
| 38 | Renoprotective effect of combining pentoxifylline with angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in advanced chronic kidney disease | Journal of the Formosan Medical Association | 2014 | 283 |
| 39 | A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia | Gut | 2007 | 279 |
| 40 | A revisit of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in non-Hodgkin's lymphoma: A randomized trial | Hepatology | 2008 | 277 |
| 41 | Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. | Journal of Clinical Investigation | 1992 | 277 |
| 42 | Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis | Kidney International | 2011 | 273 |
| 43 | Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling | Molecular Medicine | 2015 | 272 |
| 44 | The potential biological mechanisms of arsenic-induced diabetes mellitus | Toxicology and Applied Pharmacology | 2004 | 267 |
| 45 | Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention | Circulation | 2019 | 263 |
| 46 | Long-Term Risk of Coronary Events after AKI | Journal of the American Society of Nephrology: JASN | 2014 | 262 |
| 47 | Effects of Physical Training on Functional Status in Patients With Prolonged Mechanical Ventilation | Physical Therapy | 2006 | 261 |
| 48 | Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan | Toxicology and Applied Pharmacology | 2005 | 260 |
| 49 | Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms | Nature Genetics | 2017 | 260 |
| 50 | High Prevalence and Mapping of Pre-S Deletion in Hepatitis B Virus Carriers With Progressive Liver Diseases | Gastroenterology | 2006 | 257 |
