| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Nature Genetics | 1997 | 2,596 |
| 3 | Transient Regenerative Potential of the Neonatal Mouse Heart | Science | 2011 | 2,117 |
| 4 | Suppression of Aging in Mice by the Hormone Klotho | Science | 2005 | 1,634 |
| 5 | Spike mutation D614G alters SARS-CoV-2 fitness | Nature | 2021 | 1,380 |
| 6 | Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy | Cancer Discovery | 2016 | 1,158 |
| 7 | The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo | Cell | 2002 | 1,148 |
| 8 | Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma | Cancer Cell | 2013 | 856 |
| 9 | Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing | Science | 2014 | 834 |
| 10 | Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade | Cancer Discovery | 2016 | 785 |
| 11 | HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein | Cell Host and Microbe | 2007 | 733 |
| 12 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 719 |
| 13 | Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer | Cancer | 2011 | 624 |
| 14 | Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol | Immunity | 2013 | 554 |
| 15 | Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis | Nature Medicine | 2018 | 521 |
| 16 | Re-emergence of chikungunya and o’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships | Microbiology (United Kingdom) | 2000 | 504 |
| 17 | International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading | Brain Pathology | 2014 | 499 |
| 18 | Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma | Clinical Cancer Research | 2014 | 493 |
| 19 | Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators | Cancer | 2012 | 457 |
| 20 | EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance | Cell | 2013 | 448 |
| 21 | Telomerase Activity in Small-Cell and Non-Small-Cell Lung Cancers | Journal of the National Cancer Institute | 1995 | 437 |
| 22 | Granulocytic sarcoma in nonleukemic patients | Cancer | 1986 | 420 |
| 23 | A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection | Cell Host and Microbe | 2016 | 420 |
| 24 | Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression | Cancer Discovery | 2016 | 404 |
| 25 | Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates | Cancer | 1992 | 390 |
| 26 | Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A | Neuron | 1996 | 390 |
| 27 | Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation | Lancet Oncology, The | 2013 | 383 |
| 28 | Epidermal Growth Factor Receptor in Glioma: Signal Transduction, Neuropathology, Imaging, and Radioresistance | Neoplasia | 2010 | 381 |
| 29 | cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading | Brain Pathology | 2020 | 363 |
| 30 | Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress | Cell Metabolism | 2015 | 331 |
| 31 | Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status | Laboratory Investigation | 2010 | 327 |
| 32 | The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma | Genes and Development | 2011 | 326 |
| 33 | Potential markers that complement expression of CA125 in epithelial ovarian cancer | Gynecologic Oncology | 2005 | 324 |
| 34 | Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43 | Mucosal Immunology | 2017 | 323 |
| 35 | GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3 | Mucosal Immunology | 2018 | 322 |
| 36 | Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers | International Journal of Cancer | 2010 | 320 |
| 37 | Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes | Journal of Molecular Diagnostics | 2013 | 314 |
| 38 | Inflammatory Breast Cancer: The Disease, the Biology, the Treatment | Ca-A Cancer Journal for Clinicians | 2010 | 298 |
| 39 | Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth | Cell Metabolism | 2016 | 293 |
| 40 | Human Ehrlichiosis and Anaplasmosis | Clinics in Laboratory Medicine | 2010 | 282 |
| 41 | The Pathogenesis of Rift Valley Fever | Viruses | 2011 | 282 |
| 42 | Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive | European Respiratory Journal | 2016 | 281 |
| 43 | Envelope Protein Glycosylation Status Influences Mouse Neuroinvasion Phenotype of Genetic Lineage 1 West Nile Virus Strains | Journal of Virology | 2005 | 274 |
| 44 | Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer | International Journal of Cancer | 2003 | 273 |
| 45 | Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. | Journal of Immunology | 1993 | 273 |
| 46 | Extraskeletal osteosarcoma. A clinicopathologic review of 26 cases | Cancer | 1990 | 271 |
| 47 | Influenza Research Database: an integrated bioinformatics resource for influenza research and surveillance | Influenza and Other Respiratory Viruses | 2012 | 270 |
| 48 | Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer | Gastroenterology | 2019 | 270 |
| 49 | Cerebral Edema: A Major Complication of Massive Hepatic Necrosis | Gastroenterology | 1971 | 263 |
| 50 | Oleander toxicity: an examination of human and animal toxic exposures | Toxicology | 1996 | 252 |
