| # | Title | Journal | Year | Citations |
|---|
| 1 | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | Immunity | 2014 | 4,638 |
| 2 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer | Nature Reviews Cancer | 2006 | 2,049 |
| 3 | The spindle-assembly checkpoint in space and time | Nature Reviews Molecular Cell Biology | 2007 | 1,932 |
| 4 | Trained immunity: A program of innate immune memory in health and disease | Science | 2016 | 1,809 |
| 5 | The p66shc adaptor protein controls oxidative stress response and life span in mammals | Nature | 1999 | 1,619 |
| 6 | Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells | EMBO Journal | 2001 | 1,607 |
| 7 | Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication | Nature | 2006 | 1,576 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 9 | EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer | EMBO Journal | 2003 | 1,052 |
| 10 | Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia | Nature | 1998 | 1,015 |
| 11 | Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence | EMBO Journal | 2002 | 764 |
| 12 | PML regulates p53 acetylation and premature senescence induced by oncogenic Ras | Nature | 2000 | 761 |
| 13 | Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor | Science | 2002 | 754 |
| 14 | GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins | Chemistry and Biology | 2003 | 720 |
| 15 | Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells | Nature Immunology | 2005 | 719 |
| 16 | Latent Enhancers Activated by Stimulation in Differentiated Cells | Cell | 2013 | 693 |
| 17 | Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1 | Cell | 2006 | 663 |
| 18 | E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis | Genes and Development | 2001 | 654 |
| 19 | Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement | Journal of Experimental Medicine | 2006 | 647 |
| 20 | Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation | Nature Cell Biology | 2012 | 646 |
| 21 | The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation | Molecular and Cellular Biology | 2007 | 628 |
| 22 | A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins | Nature | 2002 | 592 |
| 23 | High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy | Nature Medicine | 2018 | 564 |
| 24 | Transcriptional regulation via the NF-κB signaling module | Oncogene | 2006 | 553 |
| 25 | Apaf-1 is a transcriptional target for E2F and p53 | Nature Cell Biology | 2001 | 552 |
| 26 | Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells | Journal of Experimental Medicine | 2011 | 547 |
| 27 | Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | Nature | 1998 | 520 |
| 28 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 29 | Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway | Nature Medicine | 2005 | 505 |
| 30 | The spindle checkpoint: structural insights into dynamic signalling | Nature Reviews Molecular Cell Biology | 2002 | 501 |
| 31 | E2F target genes: unraveling the biology | Trends in Biochemical Sciences | 2004 | 497 |
| 32 | Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex | Cell | 2008 | 479 |
| 33 | Nucleophosmin regulates the stability and transcriptional activity of p53 | Nature Cell Biology | 2002 | 476 |
| 34 | Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO | Molecular and Cellular Biology | 1998 | 466 |
| 35 | The E2F family: specific functions and overlapping interests | EMBO Journal | 2004 | 464 |
| 36 | Regulation of cell proliferation by the E2F transcription factors | Current Opinion in Genetics and Development | 1998 | 452 |
| 37 | Protein Kinase C and Prolyl Isomerase 1 Regulate Mitochondrial Effects of the Life-Span Determinant p66Shc | Science | 2007 | 448 |
| 38 | Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine | Journal of Cell Biology | 2010 | 447 |
| 39 | A gut-vascular barrier controls the systemic dissemination of bacteria | Science | 2015 | 446 |
| 40 | The life and miracles of kinetochores | EMBO Journal | 2009 | 420 |
| 41 | A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis | Oncogene | 2002 | 410 |
| 42 | Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions | Cell | 2012 | 407 |
| 43 | Molecular control of activation and priming in macrophages | Nature Immunology | 2016 | 392 |
| 44 | Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development | Journal of Hepatology | 2019 | 388 |
| 45 | Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells | Immunity | 2014 | 384 |
| 46 | The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint | Current Biology | 2005 | 376 |
| 47 | Live-cell 3D super-resolution imaging in thick biological samples | Nature Methods | 2011 | 376 |
| 48 | Myc represses transcription through recruitment of DNA methyltransferase corepressor | EMBO Journal | 2005 | 375 |
| 49 | Genome-wide association studies identify four ER negative–specific breast cancer risk loci | Nature Genetics | 2013 | 374 |
| 50 | Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway | EMBO Journal | 1997 | 373 |
