| # | Title | Journal | Year | Citations |
|---|
| 1 | Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice | Journal of Clinical Investigation | 2000 | 1,159 |
| 2 | Elevated copper and oxidative stress in cancer cells as a target for cancer treatment | Cancer Treatment Reviews | 2009 | 801 |
| 3 | Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability | Journal of Drug Targeting | 2004 | 626 |
| 4 | Regulation of protein kinase C ζ by PI 3-kinase and PDK-1 | Current Biology | 1998 | 600 |
| 5 | Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers | Advanced Drug Delivery Reviews | 2009 | 600 |
| 6 | Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier | Drug Development and Industrial Pharmacy | 2002 | 522 |
| 7 | Polymyxin B Sulfate and Colistin: Old Antibiotics for Emerging Multiresistant Gram-Negative Bacteria | Annals of Pharmacotherapy | 1999 | 492 |
| 8 | Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts | Critical Reviews in Toxicology | 2014 | 446 |
| 9 | Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers | Journal of Cerebral Blood Flow and Metabolism | 2016 | 432 |
| 10 | Challenges and opportunities in dermal/transdermal delivery | Therapeutic Delivery | 2010 | 428 |
| 11 | Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters | Pharmaceutical Research | 2009 | 420 |
| 12 | Nanomedicine in pulmonary delivery | International Journal of Nanomedicine | 2009 | 378 |
| 13 | An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells | Blood | 2007 | 357 |
| 14 | A comprehensive review of glycosylated bacterial natural products | Chemical Society Reviews | 2015 | 347 |
| 15 | A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells | Molecular Cancer Therapeutics | 2008 | 338 |
| 16 | Drug Absorption I: An In Situ Rat Gut Technique Yielding Realistic Absorption Rates | Journal of Pharmaceutical Sciences | 1969 | 330 |
| 17 | Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers | Frontiers in Neurology | 2017 | 317 |
| 18 | Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins | Cell | 1995 | 309 |
| 19 | Nanomedicinal strategies to treat multidrug-resistant tumors: current progress | Nanomedicine | 2010 | 280 |
| 20 | Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis | Natural Product Reports | 2012 | 280 |
| 21 | Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice | Journal of Controlled Release | 2004 | 278 |
| 22 | Cross‐Linking of Gelatin Capsules and Its Relevance to Their in Vitro-in Vivo Performance | Journal of Pharmaceutical Sciences | 1994 | 274 |
| 23 | High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.) | Journal of Pharmaceutical and Biomedical Analysis | 1999 | 274 |
| 24 | Paclitaxel nanoparticles for the potential treatment of brain tumors | Journal of Controlled Release | 2004 | 268 |
| 25 | Prostaglandin catabolizing enzymes | Prostaglandins and Other Lipid Mediators | 2002 | 266 |
| 26 | Doxorubicin and Paclitaxel-Loaded Lipid-Based Nanoparticles Overcome Multidrug Resistance by Inhibiting P-Glycoprotein and Depleting ATP | Cancer Research | 2009 | 257 |
| 27 | Withaferin A targets heat shock protein 90 in pancreatic cancer cells | Biochemical Pharmacology | 2010 | 254 |
| 28 | Rapid repurposing of drugs for COVID-19 | Science | 2020 | 253 |
| 29 | Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants | Clinical Pharmacokinetics | 2002 | 252 |
| 30 | Antagonism of AT2 receptors augments Angiotensin II‐induced abdominal aortic aneurysms and atherosclerosis | British Journal of Pharmacology | 2001 | 248 |
| 31 | Microneedles permit transdermal delivery of a skin-impermeant medication to humans | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 248 |
| 32 | Chitosan-based nanoparticles for topical genetic immunization | Journal of Controlled Release | 2001 | 247 |
| 33 | Modification of post-PKS tailoring steps through combinatorial biosynthesis | Natural Product Reports | 2002 | 247 |
| 34 | Methods to Assess in Vitro Drug Release from Injectable Polymeric Particulate Systems | Pharmaceutical Research | 2006 | 239 |
| 35 | Manufactured Aluminum Oxide Nanoparticles Decrease Expression of Tight Junction Proteins in Brain Vasculature | Journal of NeuroImmune Pharmacology | 2008 | 233 |
| 36 | Emerging PEGylated drugs | Expert Opinion on Emerging Drugs | 2009 | 226 |
| 37 | Microbial genome mining for accelerated natural products discovery: is a renaissance in the making? | Journal of Industrial Microbiology and Biotechnology | 2014 | 226 |
| 38 | Brain uptake of thiamine-coated nanoparticles | Journal of Controlled Release | 2003 | 225 |
| 39 | Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration | Science | 2015 | 220 |
| 40 | Review of the Pharmacology and Clinical Profile of Bupropion, an Antidepressant and Tobacco Use Cessation Agent | CNS Neuroscience & Therapeutics | 2006 | 217 |
| 41 | Prediction of Drug Residence Times in Regions of the Human Respiratory Tract Following Aerosol Inhalation | Journal of Pharmaceutical Sciences | 1986 | 214 |
| 42 | Cyclooxygenase-2, Player or Spectator in Cyclooxygenase-2 Inhibitor-Induced Apoptosis in Prostate Cancer Cells | Journal of the National Cancer Institute | 2002 | 214 |
| 43 | Influence of Perivascular Adipose Tissue on Rat Aortic Smooth Muscle Responsiveness | Clinical and Experimental Hypertension | 1991 | 210 |
| 44 | Determination of Drug Release Kinetics from Nanoparticles: Overcoming Pitfalls of the Dynamic Dialysis Method | Molecular Pharmaceutics | 2013 | 204 |
| 45 | The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins | Pharmaceutical Research | 1999 | 201 |
| 46 | A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse | Biochemical Pharmacology | 2002 | 199 |
| 47 | Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond | Frontiers in Immunology | 2019 | 197 |
| 48 | Extension of a Pilot Study: Impact From the Cytochrome P450 2D6 Polymorphism on Outcome and Costs Associated With Severe Mental Illness | Journal of Clinical Psychopharmacology | 2000 | 194 |
| 49 | Maternal tobacco smoking, nicotine replacement and neurobehavioural development | Acta Paediatrica, International Journal of Paediatrics | 2008 | 188 |
| 50 | Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase | Journal of Biological Chemistry | 1997 | 184 |
