| # | Title | Journal | Year | Citations |
|---|
| 1 | Prediction of Mortality in Patients with Cystic Fibrosis | New England Journal of Medicine | 1992 | 928 |
| 2 | Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED | JAMA - Journal of the American Medical Association | 2016 | 628 |
| 3 | Intestinal microbiota in patients with nonalcoholic fatty liver disease | Hepatology | 2013 | 602 |
| 4 | Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. | Journal of Clinical Investigation | 1988 | 601 |
| 5 | Enzyme induction in the cytochrome P-450 system | | 1990 | 574 |
| 6 | Patterns and Costs of Health Care Use of Children With Medical Complexity | Pediatrics | 2012 | 488 |
| 7 | Sickle Cell Disease in Africa | American Journal of Preventive Medicine | 2011 | 470 |
| 8 | Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis | American Journal of Respiratory and Critical Care Medicine | 2014 | 447 |
| 9 | Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. | Journal of Clinical Oncology | 1990 | 443 |
| 10 | Arrhythmia and Mortality After the Mustard Procedure: A 30-Year Single-Center Experience | Journal of the American College of Cardiology | 1997 | 439 |
| 11 | P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma | New England Journal of Medicine | 1991 | 430 |
| 12 | Patterns of participation in recreational and leisure activities among children with complex physical disabilities | Developmental Medicine and Child Neurology | 2006 | 380 |
| 13 | Pregnancy outcome following non-obstetric surgical intervention | American Journal of Surgery | 2005 | 357 |
| 14 | Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices | Journal of Pediatric Gastroenterology and Nutrition | 2012 | 354 |
| 15 | Delayed Puberty | New England Journal of Medicine | 2012 | 344 |
| 16 | Outcomes of children at 2 years after planned cesarean birth versus planned vaginal birth for breech presentation at term: The international randomized Term Breech Trial | American Journal of Obstetrics and Gynecology | 2004 | 339 |
| 17 | Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura | Lancet, The | 1994 | 315 |
| 18 | Iron-Chelation Therapy with Oral Deferiprone in Patients with Thalassemia Major | New England Journal of Medicine | 1995 | 306 |
| 19 | Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test | Obesity | 2008 | 297 |
| 20 | Pulmonary function and clinical course in patients with cystic fibrosis after pulmonary colonization with Pseudomonas aeruginosa | Journal of Pediatrics | 1990 | 286 |
| 21 | Safety of metronidazole in pregnancy: A meta-analysis | American Journal of Obstetrics and Gynecology | 1995 | 285 |
| 22 | γ-Hydroxybutyric Acid | New England Journal of Medicine | 2005 | 285 |
| 23 | High‐frequency oscillations: The state of clinical research | Epilepsia | 2017 | 260 |
| 24 | Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents | JAMA - Journal of the American Medical Association | 2016 | 250 |
| 25 | A model of human acute lymphoblastic leukemia in immune-deficient SCID mice | Science | 1989 | 246 |
| 26 | Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study | Journal of Allergy and Clinical Immunology | 2018 | 233 |
| 27 | Shwachman syndrome: Phenotypic manifestations of sibling sets and isolated cases in a large patient cohort are similar | Journal of Pediatrics | 1999 | 231 |
| 28 | New Approaches to the Treatment of Dense Deposit Disease | Journal of the American Society of Nephrology: JASN | 2007 | 231 |
| 29 | Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial | Lancet, The | 2019 | 229 |
| 30 | Symptomatic Neonatal Arterial Ischemic Stroke: The International Pediatric Stroke Study | Pediatrics | 2011 | 225 |
| 31 | Observer Agreement for Respiratory Signs and Oximetry in Infants Hospitalized with Lower Respiratory Infections | The American Review of Respiratory Disease | 1992 | 220 |
| 32 | Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of admission and management variation in patients hospitalized with respiratory syncytial viral lower respiratory tract infection | Journal of Pediatrics | 1996 | 213 |
| 33 | Fetal Outcome After In Utero Exposure to Cancer Chemotherapy | Archives of Internal Medicine | 1992 | 211 |
| 34 | Maternal and fetal outcome after breast cancer in pregnancy | American Journal of Obstetrics and Gynecology | 1992 | 209 |
| 35 | Leukemia in Down Syndrome: A Review | Pediatric Hematology and Oncology | 1992 | 203 |
| 36 | Venous thrombosis in children | Journal of Thrombosis and Haemostasis | 2003 | 203 |
| 37 | Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations | Nature Genetics | 2005 | 198 |
| 38 | Independent predictors of long-term results after balloon pulmonary valvuloplasty. Valvuloplasty and Angioplasty of Congenital Anomalies (VACA) Registry Investigators. | Circulation | 1994 | 193 |
| 39 | The safety of mesalamine in human pregnancy: A prospective controlled cohort study | Gastroenterology | 1998 | 192 |
| 40 | Neutrophil granule contents in the pathogenesis of lung injury | Current Opinion in Hematology | 2006 | 184 |
| 41 | Shwachman syndrome: Exocrine pancreatic dysfunction and variable phenotypic expression | Gastroenterology | 1996 | 182 |
| 42 | Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn | Journal of Critical Care | 2006 | 182 |
| 43 | Human milk feeding in premature infants: Protein,fat, and carbohydrate balances in the first two weeks of life | Journal of Pediatrics | 1981 | 178 |
| 44 | Practice Variations in the Treatment of Febrile Infants Among Pediatric Emergency Physicians | Pediatrics | 2009 | 177 |
| 45 | Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the american association for the study of liver diseases, american society of transplantation and the north american society for pediatric gastroenterology, hepatolo | Hepatology | 2014 | 176 |
| 46 | Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease | Gastroenterology | 2014 | 175 |
| 47 | Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group | Journal of Clinical Oncology | 2021 | 174 |
| 48 | Underlying Causes of Recurrent Pneumonia in Children | JAMA Pediatrics | 2000 | 164 |
| 49 | Pregnancy Outcome Following First Trimester Exposure to Antihistamines: Meta-Analysis | American Journal of Perinatology | 1997 | 162 |
| 50 | Overexpression of the Serine Elastase Inhibitor Elafin Protects Transgenic Mice From Hypoxic Pulmonary Hypertension | Circulation | 2002 | 162 |
