| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation | American Journal of Gastroenterology | 2007 | 688 |
| 4 | Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial | Lancet, The | 2012 | 560 |
| 5 | Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer | Journal of Biological Chemistry | 2006 | 486 |
| 6 | Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease | World Journal of Gastroenterology | 2007 | 469 |
| 7 | A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis | Nature Genetics | 2007 | 435 |
| 8 | Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society | Esophagus | 2015 | 383 |
| 9 | Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma | Clinical Gastroenterology and Hepatology | 2011 | 358 |
| 10 | p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells | Cancer Cell | 2016 | 353 |
| 11 | Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance | Nutrition Research | 2008 | 324 |
| 12 | Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version | International Journal of Clinical Oncology | 2008 | 299 |
| 13 | Excellent Long-term Outcome of ABO-Incompatible Living Donor Kidney Transplantation in Japan | American Journal of Transplantation | 2004 | 297 |
| 14 | Heme oxygenase-1 and anti-inflammatory M2 macrophages | Archives of Biochemistry and Biophysics | 2014 | 292 |
| 15 | Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)* | British Journal of Dermatology | 2021 | 289 |
| 16 | MR Tractography: A Review of Its Clinical Applications | Magnetic Resonance in Medical Sciences | 2009 | 268 |
| 17 | Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells | Oncogene | 2004 | 266 |
| 18 | Brain circuitry of compulsivity | European Neuropsychopharmacology | 2016 | 264 |
| 19 | Nationwide Epidemiologic Survey of Idiopathic Osteonecrosis of the Femoral Head | Clinical Orthopaedics and Related Research | 2010 | 260 |
| 20 | Platelet‐rich plasma enhances the initial mobilization of circulation‐derived cells for tendon healing | Journal of Cellular Physiology | 2008 | 259 |
| 21 | Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials | Lancet, The | 2021 | 259 |
| 22 | Monoallelic yet combinatorial expression of variable exons of the protocadherin-α gene cluster in single neurons | Nature Genetics | 2005 | 246 |
| 23 | The eye response test alone is sufficient to predict stroke outcome—reintroduction of Japan Coma Scale: a cohort study | BMJ Open | 2013 | 246 |
| 24 | Local Recurrence After Endoscopic Resection for Large Colorectal Neoplasia: A Multicenter Prospective Study in Japan | American Journal of Gastroenterology | 2015 | 244 |
| 25 | Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese | PLoS ONE | 2012 | 228 |
| 26 | Diffusion Anisotropy Measurement of Brain White Matter Is Affected by Voxel Size: Underestimation Occurs in Areas with Crossing Fibers | American Journal of Neuroradiology | 2007 | 227 |
| 27 | A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease | Nature Genetics | 2005 | 223 |
| 28 | AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells | Nature Communications | 2019 | 223 |
| 29 | Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastases in patients with breast cancer | European Journal of Nuclear Medicine and Molecular Imaging | 2005 | 217 |
| 30 | Current status of endoscopic resection strategy for large, early colorectal neoplasia in Japan | Surgical Endoscopy and Other Interventional Techniques | 2013 | 213 |
| 31 | Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus | Neurologia Medico-Chirurgica | 2021 | 203 |
| 32 | Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis | Journal of Gastroenterology and Hepatology (Australia) | 2010 | 191 |
| 33 | Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects | Journal of Gastroenterology | 2019 | 190 |
| 34 | Oxidative stress and delayed-onset muscle damage after exercise | Free Radical Biology and Medicine | 2004 | 188 |
| 35 | Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women | Journal of Epidemiology and Community Health | 2011 | 186 |
| 36 | Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer | Journal of Translational Medicine | 2015 | 186 |
| 37 | Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 182 |
| 38 | Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients | Hepatology Research | 2005 | 180 |
| 39 | Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis | Journal of Hepatology | 2019 | 180 |
| 40 | Intervertebral Disc Regeneration Using Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel Microspheres | Tissue Engineering | 2007 | 178 |
| 41 | Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice | BioFactors | 2004 | 176 |
| 42 | The effectiveness of lymphangiography as a treatment method for various chyle leakages | British Journal of Radiology | 2009 | 174 |
| 43 | Survival of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Virus on Human Skin: Importance of Hand Hygiene in Coronavirus Disease 2019 (COVID-19) | Clinical Infectious Diseases | 2021 | 174 |
| 44 | PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats | Biochemical and Biophysical Research Communications | 2004 | 173 |
| 45 | A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins | Journal of Hepatology | 2006 | 171 |
| 46 | Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells | Oncogene | 2005 | 165 |
| 47 | Ectopic fat obesity presents the greatest risk for incident type 2 diabetes: a population-based longitudinal study | International Journal of Obesity | 2019 | 164 |
| 48 | Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease | Journal of Gastroenterology | 2011 | 160 |
| 49 | Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells | Atherosclerosis | 2007 | 159 |
| 50 | Loss of Scribble causes cell competition in mammalian cells | Journal of Cell Science | 2012 | 159 |
