| # | Title | Journal | Year | Citations |
|---|
| 1 | Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial | Lancet Oncology, The | 2018 | 1,816 |
| 2 | Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update | Hepatology International | 2017 | 1,537 |
| 3 | Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial | Journal of Clinical Oncology | 2020 | 1,255 |
| 4 | The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease | Nature Genetics | 2007 | 1,045 |
| 5 | Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants | Biological Psychiatry | 2003 | 990 |
| 6 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014 | Hepatology International | 2014 | 861 |
| 7 | Role of TBX1 in human del22q11.2 syndrome | Lancet, The | 2003 | 776 |
| 8 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 9 | Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial | Lancet, The | 2017 | 753 |
| 10 | Real-time Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration of Mediastinal and Hilar Lymph Nodes | Chest | 2004 | 654 |
| 11 | Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche | Cell | 2011 | 654 |
| 12 | Somatic Mutations of the HER2 Kinase Domain in Lung Adenocarcinomas | Cancer Research | 2005 | 641 |
| 13 | Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity | Nature Medicine | 2003 | 639 |
| 14 | THEREGULATORYROLE OFVα14 NKT CELLS ININNATE ANDACQUIREDIMMUNERESPONSE | Annual Review of Immunology | 2003 | 637 |
| 15 | Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties | Hepatology | 2006 | 621 |
| 16 | A genome-wide association study identifies RNF213 as the first Moyamoya disease gene | Journal of Human Genetics | 2011 | 582 |
| 17 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal | Journal of Gastroenterology | 2006 | 549 |
| 18 | JSH Consensus-Based Clinical Practice Guidelines for the Management of Hepatocellular Carcinoma: 2014 Update by the Liver Cancer Study Group of Japan | Liver Cancer | 2014 | 512 |
| 19 | Guidelines for the use of flow cytometry and cell sorting in immunological studies* | European Journal of Immunology | 2017 | 505 |
| 20 | Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells | Nature | 2012 | 483 |
| 21 | TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8 + T cell exhaustion | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 481 |
| 22 | ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis | Nature Neuroscience | 2001 | 470 |
| 23 | Comparison of Endobronchial Ultrasound, Positron Emission Tomography, and CT for Lymph Node Staging of Lung Cancer | Chest | 2006 | 467 |
| 24 | Decreased Serum Levels of D-Serine in Patients With Schizophrenia | Archives of General Psychiatry | 2003 | 461 |
| 25 | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion | Neurology | 2004 | 455 |
| 26 | Physiological and pathophysiological roles of ATP-sensitive K+ channels | Progress in Biophysics and Molecular Biology | 2003 | 451 |
| 27 | Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer | Lung Cancer | 2005 | 445 |
| 28 | PIK3CA Mutations and Copy Number Gains in Human Lung Cancers | Cancer Research | 2008 | 399 |
| 29 | Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1 | Esophagus | 2019 | 394 |
| 30 | Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis | Journal of Experimental Medicine | 2000 | 390 |
| 31 | Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society | Esophagus | 2015 | 383 |
| 32 | Identification of novel microRNA targets based on microRNA signatures in bladder cancer | International Journal of Cancer | 2009 | 380 |
| 33 | A Phase I Study of α-Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer | Clinical Cancer Research | 2005 | 379 |
| 34 | Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt | Molecular Cell | 2008 | 375 |
| 35 | Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease | Hepatology | 2003 | 362 |
| 36 | In vivo electroporation in the embryonic mouse central nervous system | Nature Protocols | 2006 | 354 |
| 37 | Regulatory Roles for APJ, a Seven-transmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo | Journal of Biological Chemistry | 2004 | 349 |
| 38 | CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm | International Immunology | 2016 | 343 |
| 39 | Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow | Journal of Cell Biology | 2003 | 339 |
| 40 | Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines | Journal of Hepato-Biliary-Pancreatic Surgery | 2007 | 334 |
| 41 | Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer | Surgical Endoscopy and Other Interventional Techniques | 2005 | 325 |
| 42 | TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2013 | 321 |
| 43 | Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity | Cancer Discovery | 2017 | 321 |
| 44 | Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2 | Esophagus | 2019 | 321 |
| 45 | The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells | Immunity | 2014 | 320 |
| 46 | Protective Role of ATP-Sensitive Potassium Channels in Hypoxia-Induced Generalized Seizure | Science | 2001 | 318 |
| 47 | Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion | Journal of Biological Chemistry | 2001 | 313 |
| 48 | miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer | British Journal of Cancer | 2010 | 308 |
| 49 | Tyk2 Plays a Restricted Role in IFNα Signaling, Although It Is Required for IL-12-Mediated T Cell Function | Immunity | 2000 | 307 |
| 50 | Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update | Liver Cancer | 2021 | 307 |
