| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Colorectal cancer statistics, 2017 | Ca-A Cancer Journal for Clinicians | 2017 | 3,300 |
| 4 | Lung cancer: current therapies and new targeted treatments | Lancet, The | 2017 | 2,267 |
| 5 | Measurement and Interpretation of the Ankle-Brachial Index | Circulation | 2012 | 1,232 |
| 6 | Patient-derived tumour xenografts as models for oncology drug development | Nature Reviews Clinical Oncology | 2012 | 1,091 |
| 7 | Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase | Nature | 1990 | 1,084 |
| 8 | Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II | Nature | 1988 | 1,053 |
| 9 | Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials | Lancet Oncology, The | 2020 | 1,034 |
| 10 | RE-AIM Planning and Evaluation Framework: Adapting to New Science and Practice With a 20-Year Review | Frontiers in Public Health | 2019 | 1,017 |
| 11 | Repetitive Elements May Comprise Over Two-Thirds of the Human Genome | PLoS Genetics | 2011 | 907 |
| 12 | Inhibition of the production and effects of interleukins-1 and tumor necrosis factor α in rheumatoid arthritis | Arthritis and Rheumatism | 1995 | 902 |
| 13 | Diabetes and Cancer: A Consensus Report | Ca-A Cancer Journal for Clinicians | 2010 | 724 |
| 14 | Cyclin is a component of maturation-promoting factor from Xenopus | Cell | 1990 | 684 |
| 15 | EAACI Molecular Allergology User's Guide | Pediatric Allergy and Immunology | 2016 | 642 |
| 16 | Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia | Cancer Cell | 2012 | 621 |
| 17 | Exercise management in type 1 diabetes: a consensus statement | Lancet Diabetes and Endocrinology,the | 2017 | 588 |
| 18 | Rivaroxaban in Peripheral Artery Disease after Revascularization | New England Journal of Medicine | 2020 | 566 |
| 19 | Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine | Nature | 1980 | 565 |
| 20 | Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II | Nature Structural and Molecular Biology | 2012 | 556 |
| 21 | CLASSIFICATIONS OF ANTERIOR PITUITARY CELL TYPES WITH IMMUNOENZYME HISTOCHEMISTRY | Journal of Histochemistry and Cytochemistry | 1970 | 505 |
| 22 | Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia | Nature Medicine | 2018 | 496 |
| 23 | Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling | Nature Genetics | 2014 | 490 |
| 24 | Competitive antagonists of bradykinin | Peptides | 1985 | 477 |
| 25 | Bevacizumab and paclitaxel–carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial | Lancet Oncology, The | 2017 | 460 |
| 26 | ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state | Pediatric Diabetes | 2018 | 455 |
| 27 | Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial | Lancet, The | 2019 | 433 |
| 28 | 2016 Annual Report of The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry | Journal of the American College of Cardiology | 2017 | 429 |
| 29 | 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: What is new and what has changed? | Cancer | 2017 | 428 |
| 30 | Maternal obesity and fetal metabolic programming: a fertile epigenetic soil | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2010 | 424 |
| 31 | Predictors of Acute Complications in Children With Type 1 Diabetes | JAMA - Journal of the American Medical Association | 2002 | 405 |
| 32 | Vertebrate Photoreceptors | Progress in Retinal and Eye Research | 2001 | 399 |
| 33 | Structural Basis for the Histone Chaperone Activity of Asf1 | Cell | 2006 | 398 |
| 34 | Trends in Emergency Department Visits and Hospital Admissions in Health Care Systems in 5 States in the First Months of the COVID-19 Pandemic in the US | JAMA Internal Medicine | 2020 | 387 |
| 35 | Pathogenesis of chronic obstructive pulmonary disease | Journal of Clinical Investigation | 2012 | 383 |
| 36 | Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY) | Diabetologia | 1996 | 380 |
| 37 | Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases | JAMA Oncology | 2017 | 376 |
| 38 | Inherited causes of clonal haematopoiesis in 97,691 whole genomes | Nature | 2020 | 376 |
| 39 | Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline | Journal of Clinical Endocrinology and Metabolism | 2017 | 366 |
| 40 | MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals | Molecular and Cellular Biology | 2008 | 363 |
| 41 | Studies in human lactation: milk volumes in lactating women during the onset of lactation and full lactation. | American Journal of Clinical Nutrition | 1988 | 353 |
| 42 | Variant ofTYRand Autoimmunity Susceptibility Loci in Generalized Vitiligo | New England Journal of Medicine | 2010 | 352 |
| 43 | Systolic Blood Pressure in Childhood Predicts Hypertension and Metabolic Syndrome Later in Life | Pediatrics | 2007 | 351 |
| 44 | Drug-Related Problems: Their Structure and Function | DICP: the Annals of Pharmacotherapy | 1990 | 347 |
| 45 | ADENINE NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE in vitro RAT HIPPOCAMPUS | British Journal of Pharmacology | 1980 | 344 |
| 46 | The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment | Journal of the American Medical Informatics Association: JAMIA | 2021 | 342 |
| 47 | Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms | Cancer Cell | 2015 | 341 |
| 48 | Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta‐Analysis | Journal of the American Geriatrics Society | 2016 | 341 |
| 49 | A New Taxonomy for Stakeholder Engagement in Patient-Centered Outcomes Research | Journal of General Internal Medicine | 2012 | 337 |
| 50 | Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle | Nature | 1989 | 329 |
