| # | Title | Journal | Year | Citations |
|---|
| 1 | DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression | PLoS ONE | 2011 | 338 |
| 2 | Association between serotonin transporter gene polymorphism and anxiety-related traits | Biological Psychiatry | 1999 | 189 |
| 3 | Lithium levels in drinking water and risk of suicide | British Journal of Psychiatry | 2009 | 185 |
| 4 | Assessment of the Dexamethasone/CRH Test as a State-Dependent Marker for Hypothalamic-Pituitary-Adrenal (HPA) Axis Abnormalities in Major Depressive Episode: A Multicenter Study | Neuropsychopharmacology | 2006 | 181 |
| 5 | Low-dose lithium uptake promotes longevity in humans and metazoans | European Journal of Nutrition | 2011 | 107 |
| 6 | The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression | Journal of Psychiatric Research | 2014 | 100 |
| 7 | Anticipatory anxiety-induced changes in human lateral prefrontal cortex activity | Biological Psychology | 2007 | 93 |
| 8 | Differences in Salivary Alpha-Amylase and Cortisol Responsiveness following Exposure to Electrical Stimulation versus the Trier Social Stress Tests | PLoS ONE | 2012 | 85 |
| 9 | Lithium and dementia: A preliminary study | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2006 | 83 |
| 10 | Assertive case management versus enhanced usual care for people with mental health problems who had attempted suicide and were admitted to hospital emergency departments in Japan (ACTION-J): a multicentre, randomised controlled trial | Lancet Psychiatry,the | 2014 | 75 |
| 11 | Discrepancy between subjective and objective sleep in patients with depression | Psychiatry and Clinical Neurosciences | 2003 | 72 |
| 12 | Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2006 | 69 |
| 13 | Incidence and risk factors in neuroleptic malignant syndrome | Acta Psychiatrica Scandinavica | 1994 | 67 |
| 14 | Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 2012 | 65 |
| 15 | Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review | Journal of Psychopharmacology | 2010 | 61 |
| 16 | Meta-analysis of genome-wide association studies for panic disorder in the Japanese population | Translational Psychiatry | 2012 | 59 |
| 17 | Guideline for treatment of bipolar disorder by the Japanese Society of Mood Disorders, 2012 | Psychiatry and Clinical Neurosciences | 2013 | 59 |
| 18 | Lithium in Tap Water and Suicide Mortality in Japan | International Journal of Environmental Research and Public Health | 2013 | 51 |
| 19 | Ghrelin gene polymorphism is associated with depression, but not panic disorder | Psychiatric Genetics | 2008 | 50 |
| 20 | Low Risk of Male Suicide and Lithium in Drinking Water | Journal of Clinical Psychiatry | 2015 | 49 |
| 21 | Cyclothymic and hyperthymic temperaments may predict bipolarity in major depressive disorder: A supportive evidence for bipolar II1/2 and IV | Journal of Affective Disorders | 2011 | 47 |
| 22 | Suppression of Conditioned Fear by Administration of CRF Receptor Antagonist CP-154,526 | Pharmacopsychiatry | 2000 | 44 |
| 23 | Frontal Brain Hypoactivity as a Biological Substrate of Anxiety in Patients with Panic Disorders | Neuropsychobiology | 2003 | 42 |
| 24 | Different functioning of prefrontal cortex predicts treatment response after a selective serotonin reuptake inhibitor treatment in patients with major depression | Journal of Affective Disorders | 2017 | 41 |
| 25 | A case study of Cotard's syndrome: stages and diagnosis | Acta Psychiatrica Scandinavica | 1999 | 40 |
| 26 | Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 | 39 |
| 27 | Fluctuating serotonergic function in premenstrual dysphoric disorder and premenstrual syndrome: findings from neuroendocrine challenge tests | Psychopharmacology | 2006 | 37 |
| 28 | Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder | Neuropsychobiology | 2012 | 37 |
| 29 | Trace lithium is inversely associated with male suicide after adjustment of climatic factors | Journal of Affective Disorders | 2016 | 36 |
| 30 | Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo | Neuropeptides | 2000 | 35 |
| 31 | Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients | Neuroscience Research | 2012 | 35 |
| 32 | Increased anxiety behavior in OLETF rats without cholecystokinin-A receptor | Brain Research Bulletin | 2000 | 32 |
| 33 | Reduced anxious behavior in mice lacking the CCK2 receptor gene | European Neuropsychopharmacology | 2004 | 32 |
| 34 | Elevated salivary α-amylase and cortisol levels in unremitted and remitted depressed patients | International Journal of Psychiatry in Clinical Practice | 2010 | 31 |
| 35 | Infrared radiation has potential antidepressant and anxiolytic effects in animal model of depression and anxiety | Brain Stimulation | 2011 | 31 |
| 36 | Effects of antidepressants on intracellular Ca2+ mobilization in CHO cells transfected with the human 5-HT2C receptors | Biological Psychiatry | 1996 | 30 |
| 37 | Lack of association between a polymorphism in the promoter region of the dopamine D2 receptor and personality traits | Psychiatry Research | 2001 | 30 |
| 38 | Cognitive insight and functional outcome in schizophrenia; a multi-center collaborative study with the specific level of functioning scale–Japanese version | Schizophrenia Research: Cognition | 2016 | 30 |
| 39 | Suppression of conditioned fear by administration of CCKB receptor antagonist PD135158 | Neuropeptides | 1999 | 29 |
| 40 | Spatial memory impairment in OLETF rats without cholecystokinin – a receptor | Neuropeptides | 2003 | 29 |
| 41 | Association between theCCK-A receptor gene and panic disorder | American Journal of Medical Genetics Part A | 2003 | 28 |
| 42 | Chronic Administration of Imipramine and Lithium Changes the Phase-Angle Relationship Between the Activity and Core Body Temperature Circadian Rhythms in Rats | Chronobiology International | 1996 | 27 |
| 43 | Biological aspect of hyperthymic temperament: light, sleep, and serotonin | Psychopharmacology | 2011 | 27 |
| 44 | Circadian rhythm in the response of central 5-HT1A receptors to 8-OH-DPAT in rats | Psychopharmacology | 1996 | 25 |
| 45 | Rapid Desensitization of Serotonin 5‐HT2C Receptor‐Stimulated Intracellular Calcium Mobilization in CHO Cells Transfected with Cloned Human 5‐HT2C Receptors | Journal of Neurochemistry | 1995 | 25 |
| 46 | Relationship between hostility and subjective sleep quality | Psychiatry Research | 2013 | 25 |
| 47 | Circadian and circannual rhythms in the function of central 5-HT 1A receptors in laboratory rats | Psychopharmacology | 1998 | 24 |
| 48 | Even very low but sustained lithium intake can prevent suicide in the general population? | Medical Hypotheses | 2009 | 24 |
| 49 | Association of TMEM132D, COMT, and GABRA6 genotypes with cingulate, frontal cortex and hippocampal emotional processing in panic and major depressive disorder | International Journal of Psychiatry in Clinical Practice | 2015 | 23 |
| 50 | Anxiety Induced by Repetitive Transcranial Magnetic Stimulation is Suppressed by Chronic Treatment of Paroxetine in Rats | Pharmacopsychiatry | 2003 | 22 |
