| # | Title | Journal | Year | Citations |
|---|
| 1 | A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation | Cancer Research | 2005 | 1,479 |
| 2 | Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 723 |
| 3 | Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression | Sleep Medicine | 2017 | 710 |
| 4 | A Multicenter Study on Oncologic Outcome of Laparoscopic Gastrectomy for Early Cancer in Japan | Annals of Surgery | 2007 | 624 |
| 5 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study | Journal of Gastroenterology | 2004 | 603 |
| 6 | Mechanisms of disease: Helicobacter pylori virulence factors | Nature Reviews Gastroenterology and Hepatology | 2010 | 538 |
| 7 | Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 470 |
| 8 | Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression | Sleep Medicine Reviews | 2018 | 464 |
| 9 | Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 387 |
| 10 | Polo-like kinases (Plks) and cancer | Oncogene | 2005 | 366 |
| 11 | Abdominal CT: Comparison of Low-Dose CT With Adaptive Statistical Iterative Reconstruction and Routine-Dose CT With Filtered Back Projection in 53 Patients | American Journal of Roentgenology | 2010 | 358 |
| 12 | DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression | PLoS ONE | 2011 | 338 |
| 13 | Epidemiology of Helicobacter pylori Infection and Public Health Implications | Helicobacter | 2011 | 316 |
| 14 | Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy forHelicobacter pylorieradication: a phase III, randomised, double-blind study | Gut | 2016 | 309 |
| 15 | Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan | Blood | 2010 | 303 |
| 16 | Short-Term Surgical Outcomes From a Randomized Controlled Trial to Evaluate Laparoscopic and Open D3 Dissection for Stage II/III Colon Cancer | Annals of Surgery | 2014 | 289 |
| 17 | Tokyo Guidelines 2018: surgical management of acute cholecystitis: safe steps in laparoscopic cholecystectomy for acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 281 |
| 18 | l-Cysteine Inhibits Insulin Release From the Pancreatic β-Cell | Diabetes | 2006 | 269 |
| 19 | Genome‐wide microRNA expression profiling in renal cell carcinoma: significant down‐regulation of miR‐141 and miR‐200c | Journal of Pathology | 2008 | 251 |
| 20 | Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 248 |
| 21 | Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 242 |
| 22 | Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus | Gut | 2020 | 239 |
| 23 | Primary antibiotic resistance in Helicobacter pylori in the Asia-Pacific region: a systematic review and meta-analysis | The Lancet Gastroenterology and Hepatology | 2017 | 238 |
| 24 | A Multi‐institutional, Prospective, Phase II Feasibility Study of Laparoscopy‐Assisted Distal Gastrectomy with D2 Lymph Node Dissection for Locally Advanced Gastric Cancer (JLSSG0901) | World Journal of Surgery | 2015 | 237 |
| 25 | CLP1 links tRNA metabolism to progressive motor-neuron loss | Nature | 2013 | 231 |
| 26 | Tokyo Guidelines 2018: management strategies for gallbladder drainage in patients with acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 220 |
| 27 | Variations in the FTO gene are associated with severe obesity in the Japanese | Journal of Human Genetics | 2008 | 219 |
| 28 | Central control of fever and female body temperature by RANKL/RANK | Nature | 2009 | 212 |
| 29 | Survival outcomes following laparoscopic versus open D3 dissection for stage II or III colon cancer (JCOG0404): a phase 3, randomised controlled trial | The Lancet Gastroenterology and Hepatology | 2017 | 208 |
| 30 | Helicobacter pylori infection and antibiotic resistance — from biology to clinical implications | Nature Reviews Gastroenterology and Hepatology | 2021 | 198 |
| 31 | Apelin, an APJ Receptor Ligand, Regulates Body Adiposity and Favors the Messenger Ribonucleic Acid Expression of Uncoupling Proteins in Mice | Endocrinology | 2007 | 196 |
| 32 | Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions | FEBS Letters | 2007 | 194 |
| 33 | Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway | Nature Medicine | 2004 | 191 |
| 34 | Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition | Helicobacter | 2019 | 189 |
| 35 | Lithium levels in drinking water and risk of suicide | British Journal of Psychiatry | 2009 | 185 |
| 36 | Assessment of the Dexamethasone/CRH Test as a State-Dependent Marker for Hypothalamic-Pituitary-Adrenal (HPA) Axis Abnormalities in Major Depressive Episode: A Multicenter Study | Neuropsychopharmacology | 2006 | 181 |
| 37 | Lateral supraorbital approach as an alternative to the classical pterional approach | | 2005 | 177 |
| 38 | Human Herpesvirus 6 DNA in Plasma after Allogeneic Stem Cell Transplantation: Incidence and Clinical Significance | Journal of Infectious Diseases | 2006 | 175 |
| 39 | Pharmacogenomics-based Tailored Versus Standard Therapeutic Regimen for Eradication of H. pylori | Clinical Pharmacology and Therapeutics | 2007 | 167 |
| 40 | Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma | Cancer | 2005 | 160 |
| 41 | Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 157 |
| 42 | A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011–2015 update | Journal of Gastroenterology | 2019 | 156 |
| 43 | The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans | Pharmacogenetics and Genomics | 2011 | 153 |
| 44 | Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer | Oncogene | 2006 | 151 |
| 45 | Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics | Cancer and Metastasis Reviews | 2007 | 147 |
| 46 | Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma | Nature Genetics | 2016 | 147 |
| 47 | Changing Antimicrobial Susceptibility Epidemiology of Helicobacter pylori Strains in Japan between 2002 and 2005 | Journal of Clinical Microbiology | 2007 | 146 |
| 48 | Efficacy of Left Atrial Voltage‐Based Catheter Ablation of Persistent Atrial Fibrillation | Journal of Cardiovascular Electrophysiology | 2016 | 146 |
| 49 | Clinical Practice Guidelines for Nursing- and Healthcare-associated Pneumonia (NHCAP) [Complete translation] | Respiratory Investigation | 2013 | 143 |
| 50 | Fulminant type 1 diabetes mellitus with anti‐programmed cell death‐1 therapy | Journal of Diabetes Investigation | 2016 | 139 |
