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First Department of Internal Medicine
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top-articles
First Department of Internal Medicine
220
(top 1%)
papers
6.4K
(top 1%)
citations
39
(top 1%)
h
-index
72
(top 1%)
g
-index
312
all documents
7.0K
doc citations
1.4K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes
Journal of General Virology
1988
972
2
Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
Infection and Immunity
1997
213
3
IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production.
Journal of Immunology
1997
162
4
IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans
Clinical and Experimental Immunology
1996
154
5
IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production
Journal of Immunology
1997
145
6
Monocyte Chemoattractant Protein-1-Dependent Increase of Vα14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection
Journal of Immunology
2001
144
7
A mechanism of pathogenicity of Streptococcus milleri group" in pulmonary infection: synergy with an anaerobe
Journal of Medical Microbiology
1994
140
8
Activation of Vα14+ Natural Killer T Cells by α-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected with Cryptococcus neoformans
Infection and Immunity
2001
140
9
Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease
World Journal of Gastroenterology
2005
140
10
The Streptococcus milleri Group as a Cause of Pulmonary Infections
Clinical Infectious Diseases
1995
125
11
IL-18 Contributes to Host Resistance Against Infection with
Cryptococcus neoformans
in Mice with Defective IL-12 Synthesis Through Induction of IFN-γ Production by NK Cells
Journal of Immunology
2000
122
12
CRYPTOCOCCAL INFECTION AND TH1-TH2 CYTOKINE BALANCE
International Reviews of Immunology
2002
120
13
Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A
Journal of Clinical Microbiology
2009
114
14
Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans: effects of interleukin-12
Infection and Immunity
1997
113
15
Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease
Journal of Medical Virology
2003
101
16
Strongyloidiasis-Progress in Diagnosis and Treatment.
Internal Medicine
2000
94
17
High Plasma Osteopontin Level and Its Relationship with Interleukin-12–mediated Type 1 T Helper Cell Response in Tuberculosis
American Journal of Respiratory and Critical Care Medicine
2003
92
18
Contribution of IL-18 to Th1 Response and Host Defense Against Infection by
Mycobacterium tuberculosis
: A Comparative Study with IL-12p40
Journal of Immunology
2002
89
19
Prospective multicenter study of the causative organisms of community-acquired pneumonia in adults in Japan
Journal of Infection and Chemotherapy
2006
86
20
Contribution of tumour necrosis factor-alpha (TNF-alpha) in host defence mechanism against Cryptococcus neoformans
Clinical and Experimental Immunology
1996
84
21
Differential Roles of Toll-Like Receptors 2 and 4 in In Vitro Responses of Macrophages to Legionella pneumophila
Infection and Immunity
2005
84
22
Efficacy of ivermectin for chronic strongyloidiasis: two single doses given 2 weeks apart
Journal of Infection and Chemotherapy
2002
74
23
Detection of Legionella spp. in cooling tower water by the polymerase chain reaction method
Applied and Environmental Microbiology
1993
65
24
T Cell‐Dependent Activation of Macrophages and Enhancement of Their Phagocytic Activity in the Lungs of Mice Inoculated with Heat‐Killed
Cryptococcus neoformans
: Involvement of IFN‐γ and Its Protective Effect against Cryptococcal Infection
Microbiology and Immunology
1995
63
25
Cell-mediated immunity in host resistance against infection caused by
Penicillium marneffei
Medical Mycology
1996
63
26
High plasma concentrations of osteopontin in patients with interstitial pneumonia
Respiratory Medicine
2005
61
27
Hepatitis delta virus genotype IIb predominates in an endemic area, Okinawa, Japan
1999
60
28
Chronic hepatitis delta virus infection with genotype IIb variant is correlated with progressive liver disease
Journal of General Virology
2003
60
29
Candida albicanssuppresses nitric oxide (NO) production by interferon-gamma (IFN-γ) and lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages
Clinical and Experimental Immunology
1999
57
30
Enhancing effect of oxygen radical scavengers on murine macrophage anticryptococcal activity through production of nitric oxide
Clinical and Experimental Immunology
2007
56
31
Quantitation of the Level of Hepatitis Delta Virus RNA in Serum, by Real‐Time Polymerase Chain Reaction—and Its Possible Correlation with the Clinical Stage of Liver Disease
Journal of Infectious Diseases
2004
53
32
Reduced host resistance and Th1 response toCryptococcus neoformansin interleukin-18 deficient mice
FEMS Microbiology Letters
2000
52
33
Inhibition of Legionella pneumophila in guinea pig peritoneal macrophages by new quinolone, macrolide and other antimicrobial agents
Journal of Antimicrobial Chemotherapy
1991
51
34
Interferon-gamma (IFN-γ)-dependent protection and synthesis of chemoattractants for mononuclear leucocytes caused by IL-12 in the lungs of mice infected with Cryptococcus neoformans
Clinical and Experimental Immunology
1999
49
35
Diagnosis of Legionella pneumophila Infection by Polymerase Chain Reaction
Clinical Infectious Diseases
1995
48
36
Enhanced Gamma Interferon Production through Activation of Vα14 + Natural Killer T Cells by α-Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis
Infection and Immunity
2001
48
37
Cryptococcus neoformansInhibits Nitric Oxide Production by Murine Peritoneal Macrophages Stimulated with Interferon-γ and Lipopolysaccharide
Cellular Immunology
1997
47
38
Distribution of Legionella longbeachae and other legionellae in Japanese potting soils
Journal of Infection and Chemotherapy
2001
46
39
Activation of macrophages and expansion of specific T lymphocytes in the lungs of mice intratracheally inoculated with
Cryptococcus neoformans
Clinical and Experimental Immunology
2008
46
40
Clinical evaluation methods for new antimicrobial agents to treat respiratory infections: Report of the Committee for the Respiratory System, Japan Society of Chemotherapy
Journal of Infection and Chemotherapy
1999
43
41
NK Cells Eliminate
Cryptococcus neoformans
by Potentiating the Fungicidal Activity of Macrophages Rather than by Directly Killing Them upon Stimulation with IL‐12 and IL‐18
Microbiology and Immunology
2000
41
42
Preponderance of hepatitis B virus genotype B contributes to a better prognosis of chronic HBV infection in Okinawa, Japan
Journal of Medical Virology
2002
41
43
Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: A prospective study
Journal of Medical Virology
2003
41
44
Penicillium marneffei Causes Osteopontin-Mediated Production of Interleukin-12 by Peripheral Blood Mononuclear Cells
Infection and Immunity
2002
40
45
Contribution of interferon-γ in protecting mice during pulmonary and disseminated infection with
FEMS Immunology and Medical Microbiology
1996
39
46
Sparfloxacin Resistance in Clinical Isolates of
Streptococcus pneumoniae
: Involvement of Multiple Mutations in
gyrA
and
parC
Genes
Antimicrobial Agents and Chemotherapy
1998
39
47
Anticryptococcal effect of amphotericin B is mediated through macrophage production of nitric oxide
Antimicrobial Agents and Chemotherapy
1996
38
48
Different susceptibilities of yeasts and conidia of Penicillium marneffei to nitric oxide (NO)-mediated fungicidal activity of murine macrophages
Clinical and Experimental Immunology
1998
38
49
Minimal Contribution of Vα14 Natural Killer T Cells to Th1 Response and Host Resistance against Mycobacterial Infection in Mice
Microbiology and Immunology
2002
38
50
Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study
Hepatology International
2019
38
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