| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages | PLoS Pathogens | 2007 | 469 |
| 3 | IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection | Journal of Immunology | 2007 | 466 |
| 4 | Pachychoroid disease | Eye | 2019 | 443 |
| 5 | Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung | Journal of Immunology | 2010 | 338 |
| 6 | IL-17A Produced by γδ T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver | Journal of Immunology | 2008 | 312 |
| 7 | The prehistoric peopling of Southeast Asia | Science | 2018 | 291 |
| 8 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Nature Genetics | 2022 | 250 |
| 9 | Interleukin‐17 as an Effector Molecule of Innate and Acquired Immunity against Infections | Microbiology and Immunology | 2007 | 219 |
| 10 | Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease | Gastroenterology | 2010 | 214 |
| 11 | Nifedipine controlled-release 40 mg b.i.d. in Japanese patients with essential hypertension who responded insufficiently to nifedipine controlled-release 40 mg q.d.: a phase III, randomized, double-blind and parallel-group study | Hypertension Research | 2014 | 205 |
| 12 | Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells | BMC Microbiology | 2010 | 195 |
| 13 | IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome | Pediatric Nephrology | 2020 | 179 |
| 14 | Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development | Neuron | 2010 | 176 |
| 15 | Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin | Phytomedicine | 2007 | 167 |
| 16 | Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin | Nature Genetics | 2016 | 165 |
| 17 | Distribution of Putative Adhesins in Different Seropathotypes of Shiga Toxin-Producing Escherichia coli | Journal of Clinical Microbiology | 2004 | 152 |
| 18 | Defective Epstein–Barr virus in chronic active infection and haematological malignancy | Nature Microbiology | 2019 | 152 |
| 19 | Periostin, a Matricellular Protein, Plays a Role in the Induction of Chemokines in Pulmonary Fibrosis | American Journal of Respiratory Cell and Molecular Biology | 2012 | 150 |
| 20 | Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes | Nature Communications | 2016 | 149 |
| 21 | Transcriptional activation of survivin through the NF-κB pathway by human T-cell leukemia virus type I tax | International Journal of Cancer | 2005 | 140 |
| 22 | An atlas of substrate specificities for the human serine/threonine kinome | Nature | 2023 | 140 |
| 23 | A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 138 |
| 24 | Biodegradation of high-toughness double network hydrogels as potential materials for artificial cartilage | Journal of Biomedical Materials Research - Part A | 2007 | 138 |
| 25 | A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes | Diabetes | 2018 | 136 |
| 26 | A review of clinical characteristics and genetic backgrounds in Alport syndrome | Clinical and Experimental Nephrology | 2019 | 135 |
| 27 | The Traf2- and Nck-interacting Kinase as a Putative Effector of Rap2 to Regulate Actin Cytoskeleton | Journal of Biological Chemistry | 2004 | 133 |
| 28 | Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response | Cell Reports | 2014 | 130 |
| 29 | Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems | Nature Communications | 2012 | 129 |
| 30 | Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis | BMJ Open | 2018 | 127 |
| 31 | Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling | Journal of Immunology | 2010 | 124 |
| 32 | Revised trauma scoring system to predict in-hospital mortality in the emergency department: Glasgow Coma Scale, Age, and Systolic Blood Pressure score | Critical Care | 2011 | 124 |
| 33 | The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function | Molecular Psychiatry | 2011 | 124 |
| 34 | Antibiotic Resistance Conferred by a Class I Integron and SXT Constin in Vibrio cholerae O1 Strains Isolated in Laos | Antimicrobial Agents and Chemotherapy | 2004 | 119 |
| 35 | Fucoidan Extracted From Cladosiphon Okamuranus Tokida Induces Apoptosis of Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells | Nutrition and Cancer | 2005 | 119 |
| 36 | Antiadult T‐cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol | International Journal of Cancer | 2008 | 116 |
| 37 | Modulation of Human Immunodeficiency Virus Type 1 Infectivity through Incorporation of Tetraspanin Proteins | Journal of Virology | 2008 | 114 |
| 38 | Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 as a Putative Effector of Rap2 to Activate the c-Jun N-terminal Kinase | Journal of Biological Chemistry | 2004 | 113 |
| 39 | Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes | Stem Cell Reports | 2018 | 113 |
| 40 | Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs | Blood | 2011 | 112 |
| 41 | Sensitive and rapid detection ofShigellaand enteroinvasiveEscherichia coliby a loop-mediated isothermal amplification method | FEMS Microbiology Letters | 2005 | 97 |
| 42 | Free Radical Scavenging and Hepatoprotective Actions of the Medicinal Herb, Crassocephalum crepidioides from the Okinawa Islands | Biological and Pharmaceutical Bulletin | 2005 | 95 |
| 43 | New Animal Model of Shigellosis in the Guinea Pig: Its Usefulness for Protective Efficacy Studies | Journal of Immunology | 2007 | 95 |
| 44 | A Compendium for Mycoplasma pneumoniae | Frontiers in Microbiology | 2016 | 93 |
| 45 | High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model | Oncotarget | 2016 | 93 |
| 46 | Advances in regenerative therapy: A review of the literature and future directions | Regenerative Therapy | 2020 | 92 |
| 47 | The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020) | Journal of Intensive Care | 2021 | 92 |
| 48 | Macrophage Glucose-6-Phosphate Dehydrogenase Stimulates Proinflammatory Responses with Oxidative Stress | Molecular and Cellular Biology | 2013 | 90 |
| 49 | Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas | Cancer Letters | 2011 | 88 |
| 50 | Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice | Diabetes | 2012 | 87 |
