| # | Title | Journal | Year | Citations |
|---|
| 1 | Regulation of Cellular Metabolism by Protein Lysine Acetylation | Science | 2010 | 1,642 |
| 2 | The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature | DNA and Cell Biology | 1993 | 1,596 |
| 3 | The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy | Biochimica Et Biophysica Acta - Bioenergetics | 1998 | 1,201 |
| 4 | JmjC-domain-containing proteins and histone demethylation | Nature Reviews Genetics | 2006 | 1,096 |
| 5 | A genetically encoded photoactivatable Rac controls the motility of living cells | Nature | 2009 | 960 |
| 6 | Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors | Annual Review of Physiology | 1994 | 918 |
| 7 | New Nomenclature for Chromatin-Modifying Enzymes | Cell | 2007 | 849 |
| 8 | A proficient enzyme | Science | 1995 | 845 |
| 9 | The Depth of Chemical Time and the Power of Enzymes as Catalysts | Accounts of Chemical Research | 2001 | 819 |
| 10 | A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia | Science | 2012 | 649 |
| 11 | Bax suppresses tumorigenesis and stimulates apoptosis in vivo | Nature | 1997 | 631 |
| 12 | Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis | Cell | 2006 | 563 |
| 13 | Advances in protein structure prediction and design | Nature Reviews Molecular Cell Biology | 2019 | 489 |
| 14 | JNK phosphorylates paxillin and regulates cell migration | Nature | 2003 | 442 |
| 15 | Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte | Development (Cambridge) | 2009 | 432 |
| 16 | Rates of Uncatalyzed Peptide Bond Hydrolysis in Neutral Solution and the Transition State Affinities of Proteases | Journal of the American Chemical Society | 1996 | 426 |
| 17 | Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | Nature Cell Biology | 2003 | 390 |
| 18 | FXXLF and WXXLF Sequences Mediate the NH2-terminal Interaction with the Ligand Binding Domain of the Androgen Receptor | Journal of Biological Chemistry | 2000 | 384 |
| 19 | Automated minimization of steric clashes in protein structures | Proteins: Structure, Function and Bioinformatics | 2011 | 372 |
| 20 | Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 358 |
| 21 | Use of fluorescent probes to monitor molecular order and motions within liposome bilayers | Chemistry and Physics of Lipids | 1993 | 357 |
| 22 | Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 354 |
| 23 | Cognition, Mechanism, and Evolutionary Relationships in Aminoacyl-tRNA Synthetases | Annual Review of Biochemistry | 1993 | 353 |
| 24 | Hydrophilicity of cavities in proteins | | 1996 | 350 |
| 25 | Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis | Nature | 2020 | 334 |
| 26 | A Cathepsin L Isoform that Is Devoid of a Signal Peptide Localizes to the Nucleus in S Phase and Processes the CDP/Cux Transcription Factor | Molecular Cell | 2004 | 324 |
| 27 | Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage | Nature Cell Biology | 2004 | 322 |
| 28 | Inclusion of Loss of Translational and Rotational Freedom in Theoretical Estimates of Free Energies of Binding. Application to a Complex of Benzene and Mutant T4 Lysozyme | Journal of the American Chemical Society | 1997 | 311 |
| 29 | The ribosome as an entropy trap | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 311 |
| 30 | Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase | Science | 1994 | 308 |
| 31 | Recognition and processing of cisplatin- and oxaliplatin-DNA adducts | Critical Reviews in Oncology/Hematology | 2005 | 306 |
| 32 | Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation | Molecular and Cellular Biology | 2007 | 305 |
| 33 | Redox regulation of cell signalling | Nature | 1996 | 299 |
| 34 | Hidden dynamic allostery in a PDZ domain | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 296 |
| 35 | Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor) | Biophysical Journal | 1995 | 293 |
| 36 | DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases | Genes and Development | 2006 | 287 |
| 37 | Ab Initio Folding of Proteins with All-Atom Discrete Molecular Dynamics | Structure | 2008 | 287 |
| 38 | Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1 | Neuron | 1994 | 277 |
| 39 | AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation | Nature Chemical Biology | 2012 | 274 |
| 40 | YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism | Cell | 1992 | 271 |
| 41 | Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein. | Journal of Cell Biology | 1991 | 270 |
| 42 | Cockayne syndrome group B protein enhances elongation by RNA polymerase II | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 269 |
| 43 | A cryptochrome/photolyase class of enzymes with single-stranded DNA-specific photolyase activity | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 264 |
| 44 | The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression | Journal of Biological Chemistry | 2003 | 261 |
| 45 | Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals | EMBO Journal | 2009 | 254 |
| 46 | Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function | Journal of Biological Chemistry | 2004 | 253 |
| 47 | Comparison of a QM/MM force field and molecular mechanics force fields in simulations of alanine and glycine “dipeptides” (Ace-Ala-Nme and Ace-Gly-Nme) in water in relation to the problem of modeling the unfolded peptide backbone in solution | Proteins: Structure, Function and Bioinformatics | 2003 | 250 |
| 48 | SHAPE-directed RNA secondary structure prediction | Methods | 2010 | 248 |
| 49 | DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response | Journal of the National Cancer Institute | 1996 | 244 |
| 50 | Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception | Annual Review of Biochemistry | 2000 | 242 |
