| # | Title | Journal | Year | Citations |
|---|
| 1 | Stochasticity in gene expression: from theories to phenotypes | Nature Reviews Genetics | 2005 | 2,066 |
| 2 | Signal transduction from the extracellular matrix. | Journal of Cell Biology | 1993 | 1,695 |
| 3 | Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma | Nature Genetics | 2015 | 1,491 |
| 4 | Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes | Science | 1988 | 1,341 |
| 5 | Increasing complexity of Ras signaling | Oncogene | 1998 | 977 |
| 6 | A genetically encoded photoactivatable Rac controls the motility of living cells | Nature | 2009 | 960 |
| 7 | Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis | Nature | 2010 | 929 |
| 8 | Systematic Discovery of Xist RNA Binding Proteins | Cell | 2015 | 886 |
| 9 | A day in the life of the spliceosome | Nature Reviews Molecular Cell Biology | 2014 | 831 |
| 10 | Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors | Neuron | 2009 | 809 |
| 11 | Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity | Journal of Virology | 2002 | 698 |
| 12 | Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K | Nature | 1997 | 683 |
| 13 | Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. | Journal of Biological Chemistry | 1992 | 656 |
| 14 | BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein | Cell | 1993 | 634 |
| 15 | Integrin signaling and cell growth control | Current Opinion in Cell Biology | 1998 | 629 |
| 16 | Integrin-mediated cell adhesion activates mitogen-activated protein kinases. | Journal of Biological Chemistry | 1994 | 595 |
| 17 | Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins | Pharmacological Reviews | 1998 | 581 |
| 18 | Efficient backsplicing produces translatable circular mRNAs | Rna | 2015 | 564 |
| 19 | High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: Novel penA Mosaic Allele in a Successful International Clone Causes Treatment Failure | Antimicrobial Agents and Chemotherapy | 2012 | 546 |
| 20 | Integrin-mediated cell adhesion activates mitogen-activated protein kinases | Journal of Biological Chemistry | 1994 | 543 |
| 21 | Endocrine Regulation of Male Fertility by the Skeleton | Cell | 2011 | 542 |
| 22 | Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy | Nature Nanotechnology | 2017 | 541 |
| 23 | SIGNALTRANSDUCTION BYCELLADHESIONRECEPTORS AND THECYTOSKELETON: Functions of Integrins, Cadherins, Selectins, and Immunoglobulin-Superfamily Members | Annual Review of Pharmacology and Toxicology | 2002 | 540 |
| 24 | PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome | Nature Structural and Molecular Biology | 2015 | 535 |
| 25 | Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase | Journal of Biological Chemistry | 1992 | 530 |
| 26 | CHIP Is a U-box-dependent E3 Ubiquitin Ligase | Journal of Biological Chemistry | 2001 | 528 |
| 27 | Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice | Journal of Neurophysiology | 1988 | 523 |
| 28 | Tumor-promoting functions of adenosine | Journal of Neurophysiology | 2000 | 502 |
| 29 | ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix | Journal of Cell Biology | 2003 | 474 |
| 30 | Establishment of Axon-Dendrite Polarity in Developing Neurons | Annual Review of Neuroscience | 2009 | 458 |
| 31 | Drugs and Valvular Heart Disease | New England Journal of Medicine | 2007 | 450 |
| 32 | NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease | Journal of Clinical Investigation | 2000 | 440 |
| 33 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice | Hepatology | 2001 | 437 |
| 34 | Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial | Clinical Cancer Research | 2018 | 414 |
| 35 | Efficacy of Ondansetron (Gr 38032F) and the Role of Serotonin in Cisplatin-Induced Nausea and Vomiting | New England Journal of Medicine | 1990 | 412 |
| 36 | Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides | Nucleic Acids Research | 2008 | 402 |
| 37 | Excitatory amino acid receptors in epilepsy | Trends in Pharmacological Sciences | 1990 | 393 |
| 38 | Sarcoplasmic reticulum contains adenine nucleotide-activated calcium channels | Nature | 1985 | 389 |
| 39 | Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 388 |
| 40 | Clinging to life: cell to matrix adhesion and cell survival | Cancer and Metastasis Reviews | 2005 | 384 |
| 41 | LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons | Cell | 2007 | 377 |
| 42 | Different Signaling and Cell Death Roles of Heterotrimeric G Protein α and β Subunits in the Arabidopsis Oxidative Stress Response to Ozone | Plant Cell | 2005 | 363 |
| 43 | Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure | Nature Medicine | 2003 | 360 |
| 44 | Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish | Developmental Cell | 2010 | 338 |
| 45 | Cell adhesion molecules, signal transduction and cell growth | Current Opinion in Cell Biology | 1999 | 323 |
| 46 | Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells | Experimental Cell Research | 1982 | 319 |
| 47 | KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner | Neuron | 2009 | 319 |
| 48 | Discovery of β-Arrestin–Biased Dopamine D 2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 312 |
| 49 | Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo | Nature Cell Biology | 2010 | 297 |
| 50 | A bottom-up approach to gene regulation | Nature | 2006 | 294 |
