| # | Title | Journal | Year | Citations |
|---|
| 1 | Nomenclature of Systemic Vasculitides | Arthritis and Rheumatism | 1994 | 3,714 |
| 2 | The landscape of somatic copy-number alteration across human cancers | Nature | 2010 | 3,331 |
| 3 | Burden of Gastrointestinal Disease in the United States: 2012 Update | Gastroenterology | 2012 | 1,725 |
| 4 | Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) | Diabetologia | 2012 | 1,718 |
| 5 | Signal transduction from the extracellular matrix. | Journal of Cell Biology | 1993 | 1,695 |
| 6 | ADHD: Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents | Pediatrics | 2011 | 1,545 |
| 7 | Interpretation of the evidence for the efficacy and safety of statin therapy | Lancet, The | 2016 | 1,399 |
| 8 | Anti-Neutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase in Patients with Systemic Vasculitis and Idiopathic Necrotizing and Crescentic Glomerulonephritis | New England Journal of Medicine | 1988 | 1,377 |
| 9 | Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53 | Cell | 1992 | 1,345 |
| 10 | DNA methylation GrimAge strongly predicts lifespan and healthspan | Aging | 2019 | 1,128 |
| 11 | A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection | Nature | 1997 | 1,127 |
| 12 | Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging | Rejuvenation Research | 2005 | 1,081 |
| 13 | Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018 | Gastroenterology | 2019 | 1,040 |
| 14 | Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice | Nature Genetics | 1996 | 841 |
| 15 | DNA Repair Enzymes | Annual Review of Biochemistry | 1988 | 826 |
| 16 | Immunohistochemical localization of enkephalin in rat brain and spinal cord | Journal of Comparative Neurology | 1978 | 818 |
| 17 | Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors | Neuron | 2009 | 809 |
| 18 | Somatomedin: Proposed Designation for Sulphation Factor | Nature | 1972 | 771 |
| 19 | A consistent empirical potential for water-protein interactions | Biopolymers | 1984 | 759 |
| 20 | Epidemiology of basal-like breast cancer | Breast Cancer Research and Treatment | 2008 | 747 |
| 21 | Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration | Nature Neuroscience | 2007 | 734 |
| 22 | Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast | Cell | 1990 | 726 |
| 23 | Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus | Science | 1987 | 704 |
| 24 | Comparison of a Trial of Labor with an Elective Second Cesarean Section | New England Journal of Medicine | 1996 | 638 |
| 25 | Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy | Diabetologia | 2009 | 635 |
| 26 | Integrin signaling and cell growth control | Current Opinion in Cell Biology | 1998 | 629 |
| 27 | The Stability of Globular Protein | CRC Critical Reviews in Biochemistry | 1975 | 619 |
| 28 | Integrin-mediated cell adhesion activates mitogen-activated protein kinases. | Journal of Biological Chemistry | 1994 | 595 |
| 29 | Fetal alcohol syndrome: embryogenesis in a mouse model | Science | 1981 | 591 |
| 30 | Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins | Pharmacological Reviews | 1998 | 581 |
| 31 | The Burden of Gastrointestinal and Liver Diseases, 2006 | American Journal of Gastroenterology | 2006 | 577 |
| 32 | Human hepatic stem cells from fetal and postnatal donors | Journal of Experimental Medicine | 2007 | 551 |
| 33 | Integrin-mediated cell adhesion activates mitogen-activated protein kinases | Journal of Biological Chemistry | 1994 | 543 |
| 34 | SIGNALTRANSDUCTION BYCELLADHESIONRECEPTORS AND THECYTOSKELETON: Functions of Integrins, Cadherins, Selectins, and Immunoglobulin-Superfamily Members | Annual Review of Pharmacology and Toxicology | 2002 | 540 |
| 35 | Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes | Nature | 1987 | 521 |
| 36 | Epigenetic clock analysis of diet, exercise, education, and lifestyle factors | Aging | 2017 | 521 |
| 37 | Platinum neurotoxicity pharmacogenetics | Molecular Cancer Therapeutics | 2009 | 500 |
| 38 | Aripiprazole in the Treatment of Irritability in Children and Adolescents With Autistic Disorder | Pediatrics | 2009 | 497 |
| 39 | APIC guideline for selection and use of disinfectants | American Journal of Infection Control | 1996 | 475 |
| 40 | Assessment of Fura-2 for measurements of cytosolic free calcium | Cell Calcium | 1990 | 450 |
| 41 | Insulin-like growth factor binding proteins and their role in controlling IGF actions | Cytokine and Growth Factor Reviews | 1997 | 450 |
| 42 | Maternal inheritance of mammalian mitochondrial DNA | Nature | 1974 | 448 |
| 43 | From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations | Molecular Biology of the Cell | 2016 | 446 |
| 44 | Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline | Journal of Nutrition | 2002 | 431 |
| 45 | Associations of ankle-brachial index with clinical coronary heart disease, stroke and preclinical carotid and popliteal atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Study | Atherosclerosis | 1997 | 424 |
| 46 | The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation | Journal of Biological Chemistry | 1996 | 408 |
| 47 | Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies | Aging | 2018 | 406 |
| 48 | Sarcoplasmic reticulum contains adenine nucleotide-activated calcium channels | Nature | 1985 | 389 |
| 49 | Development of the serotonergic system in the rat embryo: An immunocytochemical study | Brain Research Bulletin | 1983 | 385 |
| 50 | Clinging to life: cell to matrix adhesion and cell survival | Cancer and Metastasis Reviews | 2005 | 384 |
