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Top Articles

#TitleJournalYearCitations
1Global Prevalence and Major Risk Factors of Diabetic RetinopathyDiabetes Care20123,439
2International consensus guidelines 2012 for the management of IPMN and MCN of the pancreasPancreatology20122,043
3Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in miceJournal of Physiology20042,024
4International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the PancreasPancreatology20061,805
5Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011Modern Rheumatology20121,294
6Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreasPancreatology20171,208
7Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypesNature Genetics20181,124
8Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityNature Genetics2014959
9Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011Modern Rheumatology2012947
10Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injuryNature Medicine2006828
11Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysisLancet, The2016792
12Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injuryNature Medicine2009754
13Mutational landscape and clonal architecture in grade II and III gliomasNature Genetics2015729
14Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos)Journal of Hepato-Biliary-Pancreatic Sciences2018723
15Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial InfarctionCirculation Research2001625
16Transmembrane TNF- : structure, function and interaction with anti-TNF agentsRheumatology2010619
17TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and MiceJournal of Immunology2004598
18The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α 1 -Adrenoceptor–Activated Ca 2+ -Permeable Cation ChannelCirculation Research2001572
19A cross-population atlas of genetic associations for 220 human phenotypesNature Genetics2021560
20Clinical diagnostic criteria of autoimmune pancreatitis: revised proposalJournal of Gastroenterology2006549
21Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east AsiansNature Genetics2012545
22Ch IP ‐Atlas: a data‐mining suite powered by full integration of public Ch IP ‐seq dataEMBO Reports2018544
23Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancerAnnals of Oncology2014541
24Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteriaSurgery Today2016541
25A gp130–Src–YAP module links inflammation to epithelial regenerationNature2015528
26Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east AsiansNature Genetics2011516
27The changing prevalence and incidence of dementia over time — current evidenceNature Reviews Neurology2017503
28Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 CommitmentJournal of Immunology2003494
29Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney diseaseClinical and Experimental Nephrology2007488
30Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of miceAmerican Journal of Physiology - Renal Physiology2012482
31Reconstitution in vitro of the entire cycle of the mouse female germ lineNature2016470
32Tokyo Guidelines 2018: flowchart for the management of acute cholecystitisJournal of Hepato-Biliary-Pancreatic Sciences2018470
33Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H OxidaseCirculation2004464
34Overview of the BioBank Japan Project: Study design and profileJournal of Epidemiology2017451
35Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of DementiaDiabetes Care2016450
36JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure　― Digest Version ―Circulation Journal2019446
37Prevalence of chronic kidney disease in the Japanese general populationClinical and Experimental Nephrology2009442
38Establishment and Characterization of a Steroidogenic Human Granulosa-Like Tumor Cell Line, KGN, That Expresses Functional Follicle-Stimulating Hormone ReceptorEndocrinology2001436
39Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitisJournal of Allergy and Clinical Immunology2019436
40Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinomaBritish Journal of Surgery2013425
41SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivityCell Host and Microbe2021421
42Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast CancerCancer Research2004418
43Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune PancreatitisJournal of Gastroenterology2008418
44Cytokines and schizophrenia: Microglia hypothesis of schizophreniaPsychiatry and Clinical Neurosciences2009414
45Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancersCancer Immunology, Immunotherapy2007413
46Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migrationNature2001407
47Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in ratsBritish Journal of Cancer2005397
48Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodentsNeuroscience2002394
49Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung CancerClinical Cancer Research2015392
50Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusionsNature Biotechnology2016392