# | Title | Journal | Year | Citations |
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1 | Calmodulin plays a pivotal role in cellular regulation | Science | 1980 | 2,480 |
2 | STATs: Signal Transducers and Activators of Transcription | Cell | 1996 | 1,359 |
3 | Cytokine receptor signalling | Nature | 1995 | 1,228 |
4 | Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene | Nature | 1996 | 1,223 |
5 | JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin | Cell | 1993 | 1,190 |
6 | Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer | Nature Genetics | 2012 | 1,186 |
7 | Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses | Cell | 1998 | 1,181 |
8 | Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells | Nature | 1996 | 1,059 |
9 | Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors | Cell | 1998 | 987 |
10 | Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components | Science | 1994 | 967 |
11 | Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase | Cell | 1993 | 955 |
12 | The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism | Nature | 2005 | 888 |
13 | Jaks and Stats in signaling by the cytokine receptor superfamily | Trends in Genetics | 1995 | 883 |
14 | Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C | Nature | 1990 | 788 |
15 | NIX is required for programmed mitochondrial clearance during reticulocyte maturation | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 768 |
16 | Role of BNIP3 and NIX in cell death, autophagy, and mitophagy | Cell Death and Differentiation | 2009 | 758 |
17 | Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis | Genes and Development | 1999 | 734 |
18 | Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis | Oncogene | 1991 | 734 |
19 | The ornithine decarboxylase gene is a transcriptional target of c-Myc. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 685 |
20 | Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor | Science | 1989 | 663 |
21 | Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation | EMBO Journal | 2011 | 655 |
22 | The Stat family in cytokine signaling | Current Opinion in Cell Biology | 2001 | 649 |
23 | Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID | Science | 1994 | 645 |
24 | The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop | EMBO Journal | 1999 | 638 |
25 | Signaling by the cytokine receptor superfamily: JAKs and STATs | Trends in Biochemical Sciences | 1994 | 637 |
26 | Defective Lymphoid Development in Mice Lacking Jak3 | Science | 1995 | 620 |
27 | Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells | Nature | 1994 | 618 |
28 | Signaling Through the Hematopoietic Cytokine Receptors | Annual Review of Immunology | 1995 | 589 |
29 | Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits | Science | 1994 | 543 |
30 | Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells | Immunity | 1999 | 530 |
31 | Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation | Blood | 2008 | 524 |
32 | Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 511 |
33 | Cyclic 3',5'-Nucleotide Phosphodiesterase | Journal of Biological Chemistry | 1971 | 493 |
34 | SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality | Cell | 1999 | 485 |
35 | JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. | Molecular and Cellular Biology | 1994 | 480 |
36 | Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis | Journal of Biological Chemistry | 1999 | 451 |
37 | Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors | Immunity | 2000 | 444 |
38 | Myc pathways provoking cell suicide and cancer | Oncogene | 2003 | 420 |
39 | Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants | Nature | 2005 | 419 |
40 | c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression | Genes and Development | 2002 | 409 |
41 | SOCS3 regulates the plasticity of gp130 signaling | Nature Immunology | 2003 | 394 |
42 | Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs | Nature | 1992 | 379 |
43 | Cyclic 3′ : 5′-Nucleotide Phosphodiesterase | Journal of Biological Chemistry | 1974 | 364 |
44 | Interferon-induced nuclear signalling by Jak protein tyrosine kinases | Nature | 1993 | 363 |
45 | Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. | Molecular and Cellular Biology | 1992 | 357 |
46 | Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1 | Immunity | 2000 | 352 |
47 | Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration | Nature Cell Biology | 2012 | 347 |
48 | Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex | Molecular and Cellular Biology | 2002 | 346 |
49 | Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. | Molecular and Cellular Biology | 1993 | 345 |
50 | The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes | Nature Communications | 2014 | 342 |