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Top Articles

#TitleJournalYearCitations
1Principles of Tumor SuppressionCell2004850
2The role of the unfolded protein response in tumour development: friend or foe?Nature Reviews Cancer2004668
3Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesityNature Genetics2005499
4Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidneyEMBO Journal2006431
5Cyclin-dependent kinases: a family portraitNature Cell Biology2009381
6Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum StressJournal of Biological Chemistry2003380
7ER chaperone functions during normal and stress conditionsJournal of Chemical Neuroanatomy2004365
8The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediatesNature2006348
9A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingNature Genetics2009317
10ATM and ataxia telangiectasiaEMBO Reports2004314
11Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activityGenes and Development2008289
12Human Leukocyte Antigen-B-Associated Transcript 3 Is Released from Tumor Cells and Engages the NKp30 Receptor on Natural Killer CellsImmunity2007284
13Long-term Safety and Efficacy Following Systemic Administration of a Self-complementary AAV Vector Encoding Human FIX Pseudotyped With Serotype 5 and 8 Capsid ProteinsMolecular Therapy2011280
14Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA ProcessingMolecular Cell2003267
15GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial ApoptosisMolecular Cell2009257
16Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney developmentDevelopment (Cambridge)2011254
17DNA Strand Break Repair and Human Genetic DiseaseAnnual Review of Genomics and Human Genetics2007251
18DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation FormationPLoS Genetics2011250
19The ER function BiP is a master regulator of ER functionMount Sinai Journal of Medicine2004247
20The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cellsGenes and Development2010243
21Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathyNature Genetics2005232
22BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic CancerAmerican Journal of Pathology2003225
23An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG AntibodiesMolecular Cell2009209
24GM1-Ganglioside-Mediated Activation of the Unfolded Protein Response Causes Neuronal Death in a Neurodegenerative GangliosidosisMolecular Cell2004208
25Loss of suppressor-of-fused function promotes tumorigenesisOncogene2007204
26E3 Ubiquitin Ligases as Regulators of Membrane Protein Trafficking and DegradationTraffic2005201
27THE LYMPHATIC VASCULATURE: Recent Progress and ParadigmsAnnual Review of Cell and Developmental Biology2005200
28Characterization of an ERAD Pathway for Nonglycosylated BiP Substrates, which Require HerpMolecular Cell2007193
29Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repairNature2011190
30N-terminal polyubiquitination and degradation of the Arf tumor suppressorGenes and Development2004180
31Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4dNature Cell Biology2003178
32Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system developmentProceedings of the National Academy of Sciences of the United States of America2006168
33Haploinsufficiency of Six3 Fails to Activate Sonic hedgehog Expression in the Ventral Forebrain and Causes HoloprosencephalyDevelopmental Cell2008160
34Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and InflammationAmerican Journal of Pathology2012154
35Role of CDK/cyclin complexes in transcription and RNA splicingCellular Signalling2005153
36Disulfide bonds in ER protein folding and homeostasisCurrent Opinion in Cell Biology2011150
37Six3 activation of Pax6 expression is essential for mammalian lens induction and specificationEMBO Journal2006147
38Crystal Structure of Human VinculinStructure2004146
39Current views on the function of the lymphatic vasculature in health and diseaseGenes and Development2010145
40Herp Is Dually Regulated by Both the Endoplasmic Reticulum Stress-specific Branch of the Unfolded Protein Response and a Branch That Is Shared with Other Cellular Stress PathwaysJournal of Biological Chemistry2004141
41The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiationDevelopmental Biology2004141
42Prox1 expression patterns in the developing and adult murine brainDevelopmental Dynamics2007138
43Neuraminidase 1 Is a Negative Regulator of Lysosomal ExocytosisDevelopmental Cell2008136
44Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic β-Cell Development and Insulin Gene ExpressionMolecular and Cellular Biology2009133
45ASAP, a Novel Protein Complex Involved in RNA Processing and ApoptosisMolecular and Cellular Biology2003131
46CDK11 Complexes Promote Pre-mRNA SplicingJournal of Biological Chemistry2003131
47A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8Nature Structural and Molecular Biology2004128
48Endothelial cell plasticity: how to become and remain a lymphatic endothelial cellDevelopment (Cambridge)2010126
49Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen SpeciesAntioxidants and Redox Signaling2009124
50Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3EMBO Journal2008122