| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization | Cell | 2015 | 2,053 |
| 3 | Coexisting Liquid Phases Underlie Nucleolar Subcompartments | Cell | 2016 | 1,463 |
| 4 | Protein Phase Separation: A New Phase in Cell Biology | Trends in Cell Biology | 2018 | 1,439 |
| 5 | The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma | Nature Genetics | 2014 | 871 |
| 6 | The whole-genome landscape of medulloblastoma subtypes | Nature | 2017 | 787 |
| 7 | THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS | Annual Review of Biochemistry | 2005 | 704 |
| 8 | Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways | Nature Reviews Molecular Cell Biology | 2009 | 703 |
| 9 | G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules | Cell | 2020 | 697 |
| 10 | Valence and patterning of aromatic residues determine the phase behavior of prion-like domains | Science | 2020 | 675 |
| 11 | C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles | Cell | 2016 | 577 |
| 12 | Phase separation in biology; functional organization of a higher order | Cell Communication and Signaling | 2016 | 571 |
| 13 | Large-Scale Sequence Analysis of Avian Influenza Isolates | Science | 2006 | 566 |
| 14 | Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis | Molecular Cell | 2014 | 550 |
| 15 | TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics | Neuron | 2017 | 493 |
| 16 | Composition-dependent thermodynamics of intracellular phase separation | Nature | 2020 | 426 |
| 17 | Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled | Molecular Cell | 2003 | 425 |
| 18 | Protein neddylation: beyond cullin–RING ligases | Nature Reviews Molecular Cell Biology | 2015 | 417 |
| 19 | The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias | Nature Genetics | 2015 | 405 |
| 20 | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases | Molecular Cell | 2009 | 403 |
| 21 | Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA | ELife | 2016 | 395 |
| 22 | Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity | Neuron | 2003 | 370 |
| 23 | Many players in BCL-2 family affairs | Trends in Biochemical Sciences | 2014 | 352 |
| 24 | The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes | Nature Communications | 2014 | 342 |
| 25 | Computed structures of core eukaryotic protein complexes | Science | 2021 | 316 |
| 26 | Cdk-Inhibitory Activity and Stability of p27Kip1 Are Directly Regulated by Oncogenic Tyrosine Kinases | Cell | 2007 | 312 |
| 27 | A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing | EMBO Journal | 2018 | 297 |
| 28 | Inhibition of β-Ketoacyl-Acyl Carrier Protein Synthases by Thiolactomycin and Cerulenin | Journal of Biological Chemistry | 2001 | 296 |
| 29 | Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments | Molecular Cell | 2018 | 286 |
| 30 | Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation | Nature Communications | 2018 | 285 |
| 31 | p27 binds cyclin–CDK complexes through a sequential mechanism involving binding-induced protein folding | Nature Structural and Molecular Biology | 2004 | 276 |
| 32 | Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions | Biochemistry | 2018 | 273 |
| 33 | biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 263 |
| 34 | A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer | Nature Structural Biology | 2002 | 251 |
| 35 | Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex | Molecular Cell | 2009 | 246 |
| 36 | Influenza in Migratory Birds and Evidence of Limited Intercontinental Virus Exchange | PLoS Pathogens | 2007 | 241 |
| 37 | Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 240 |
| 38 | Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins | Nature Structural and Molecular Biology | 2014 | 235 |
| 39 | Association of an Inherited Genetic Variant With Vincristine-Related Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia | JAMA - Journal of the American Medical Association | 2015 | 234 |
| 40 | E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification | Molecular Cell | 2009 | 228 |
| 41 | Structural Mechanisms Underlying Posttranslational Modification by Ubiquitin-Like Proteins | Annual Review of Biophysics and Biomolecular Structure | 2007 | 225 |
| 42 | An Antagonist of Dishevelled Protein-Protein Interaction Suppresses β-Catenin–Dependent Tumor Cell Growth | Cancer Research | 2007 | 223 |
| 43 | AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence | Nature | 2021 | 221 |
| 44 | Regulation of Cell Division by Intrinsically Unstructured Proteins: Intrinsic Flexibility, Modularity, and Signaling Conduits | Biochemistry | 2008 | 218 |
| 45 | Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation | Journal of the American Chemical Society | 2016 | 217 |
| 46 | Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains | Nature Chemistry | 2022 | 216 |
| 47 | Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase | Science | 2012 | 210 |
| 48 | Versatility from Protein Disorder | Science | 2012 | 206 |
| 49 | Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 204 |
| 50 | Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 | Nature | 2003 | 195 |
